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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

1-acylglycerol-3-phosphate O-acyltransferase 3

LPAAT3, AGPAT3, Lysophosphatidic acid acyltransferase 3
The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, AGPAT4, AGE, AGPAT5, V1a
Papers using LPAAT3 antibodies
Characterization of mouse lysophosphatidic acid acyltransferase 3: an enzyme with dual functions in the testis
Brown William J. et al., In The Journal of Cell Biology, 2008
... Peptide antibody against LPAAT3 was designed and generated by Pacific Immunology.
Papers on LPAAT3
Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium.
Lemaitre et al., Houston, United States. In Mol Nutr Food Res, Jul 2015
METHODS AND RESULTS: We conducted meta-analyses (N = 11 668) evaluating interactions between dietary fatty acids and genetic variants (rs174538 and rs174548 in FADS1 (fatty acid desaturase 1), rs7435 in AGPAT3 (1-acyl-sn-glycerol-3-phosphate), rs4985167 in PDXDC1 (pyridoxal-dependent decarboxylase domain-containing 1), rs780094 in GCKR (glucokinase regulatory protein), and rs3734398 in ELOVL2 (fatty acid elongase 2)).
Identification of susceptibility modules for coronary artery disease using a genome wide integrated network analysis.
Dong et al., Ningbo, China. In Gene, 2014
Our network analysis identified four susceptibility modules for CAD including a complex module that consisted of 15 functional inter-connected sub-modules, AGPAT3-AGPAT4-PPAP2B module, ITGA11-ITGB1 module and EMCN-SELL module.
Genome wide association study identifies 20 novel promising genes associated with milk fatty acid traits in Chinese Holstein.
Qiao et al., Beijing, China. In Plos One, 2013
Combined with the previously reported QTL regions and the biological functions of the genes, 20 novel promising candidates for C10:0, C12:0, C14:0, C14:1, C14 index, C18:0, C18:1n9c, C18 index, SFA, UFA and SFA/UFA were found, which composed of HTR1B, CPM, PRKG1, MINPP1, LIPJ, LIPK, EHHADH, MOGAT1, ECHS1, STAT1, SORBS1, NFKB2, AGPAT3, CHUK, OSBPL8, PRLR, IGF1R, ACSL3, GHR and OXCT1.
Polymorphisms in genes involved in the triglyceride synthesis pathway and marine omega-3 polyunsaturated fatty acid supplementation modulate plasma triglyceride levels.
Vohl et al., Québec, Canada. In J Nutrigenet Nutrigenomics, 2012
Previous studies have demonstrated that n-3 PUFA supplementation using fish oil modified the expression levels of three genes involved in the TG synthesis pathway (GPAM, AGPAT3 and AGPAT4) in peripheral blood mononuclear cells.
Common variation in fatty acid genes and resuscitation from sudden cardiac arrest.
Rea et al., Seattle, United States. In Circ Cardiovasc Genet, 2012
Single-nucleotide polymorphisms in ACSL3, AGPAT3, MLYCD, and SLC27A6 were significantly associated with survival to hospital discharge.
Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3.
Shimizu et al., Tokyo, Japan. In Faseb J, 2012
The induction of LPAAT3 during germ cell development critically contributes to the accumulation of PUFAs in testicular phospholipids, thereby possibly affecting sperm cell production.
Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria.
Agarwal et al., Dallas, United States. In J Lipid Res, 2011
enzymatic properties, tissue distribution, and subcellular localization of human AGPAT3 and AGPAT5
Role of lysophosphatidic acid acyltransferase 3 for the supply of highly polyunsaturated fatty acids in TM4 Sertoli cells.
Shimizu et al., Tokyo, Japan. In Faseb J, 2010
To investigate the role of LPAAT3 in the storage and release of PUFAs, TM4 Sertoli cells were stably transfected with LPAAT3-small hairpin (sh)RNA.
Membrane topology of human AGPAT3 (LPAAT3).
Brown et al., Ithaca, United States. In Biochem Biophys Res Commun, 2010
The data is consistent with a structural arrangement in which motif I is located in the cytoplasm and motif II is in the endoplasmic reticulum and Golgi lumen, suggesting a different model for AGPAT3/LPAAT3's enzymatic mechanism.
Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function.
Brown et al., Ithaca, United States. In J Cell Biol, 2009
Results report the identification of an integral membrane lysophosphatidic acid-specific acyltransferase, LPAAT3, which regulates Golgi membrane tubule formation, trafficking, and structure by altering phospholipids and lysophospholipids.
The Cirque du Soleil of Golgi membrane dynamics.
Bankaitis, Chapel Hill, United States. In J Cell Biol, 2009
report that lysophosphatidic acid-specific acyltransferase, LPAAT3, contributes to Golgi membrane dynamics by suppressing tubule formation.
Characterization of mouse lysophosphatidic acid acyltransferase 3: an enzyme with dual functions in the testis.
Shimizu et al., Tokyo, Japan. In J Lipid Res, 2009
Here, we demonstrated that mouse LPAAT3, previously known as mouse AGPAT3, possesses strong LPAAT activity and modest lysophosphatidylinositol acyltransferase activity with a clear preference for arachidonoyl-CoA as a donor.
Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity.
Garg et al., Dallas, United States. In Arch Biochem Biophys, 2006
Of the two well conserved acyltransferase motifs, NHX(4)D is present in AGPAT8, whereas arginine in the EGTR motif is substituted by aspartate.
Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart.
Choy et al., Winnipeg, Canada. In Biochem J, 2005
AGPAT (1-acyl-sn-glycerol 3-phosphate acyltransferase) exists in at least five isoforms in humans, termed as AGPAT1, AGPAT2, AGPAT3, AGPAT4 and AGPAT5.
Exploration of novel motifs derived from mouse cDNA sequences.
Matsuda et al., Toyonaka, Japan. In Genome Res, 2002
Conserved motif MDS00145 is a novel 1-acyl-SN-glycerol-3-phosphate acyltransferase (AGPAT) submotif containing a transmembrane domain that distinguishes AGPAT3 and AGPAT4 from all other acyltransferase domain-containing proteins.
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