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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Oxidized low density lipoprotein

LOX-1, lectin-like oxidized LDL receptor-1, OLR1
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] (from NCBI)
Top mentioned proteins: lysyl oxidase, CAN, V1a, ACID, Arachidonate 15-Lipoxygenase
Papers using LOX-1 antibodies
Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 correlates with oxidative stress markers in stable coronary artery disease
Longo Vincenzo et al., In The Indian Journal of Medical Research, 2008
... Reverse transcription polymerase chain reaction (RT-PCR) for LOX-1 gene: RNA extraction was performed with Micro-to-Midi Total RNA Purification System (Invitrogen Life technologies, USA) ...
Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells
Yang Hongxia et al., In Lipids in Health and Disease, 2004
... FBS and DMEM (Gibco, USA), NRK-52E (ATCC, USA), anti-rat LOX-1 goat antibody (Santa Cruz Biotechnology, USA), β-actin (Santa Cruz ...
Papers on LOX-1
Crystal Structure of Manganese Lipoxygenase of the Rice Blast Fungus Magnaporthe oryzae.
Chen et al., Uppsala, Sweden. In J Biol Chem, Feb 2016
The Mn coordinating sphere is similar to Fe ligands of coral 8R-LOX and soybean LOX-1, but not overlapping.
Overexpression of LOXIN protects endothelial progenitor cells from apoptosis induced by oxidized low density lipoprotein.
Aguayo et al., Concepción, Chile. In J Cardiovasc Pharmacol, Feb 2016
Recently it has been demonstrated that hEPC express lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and its activation by oxidized low-density lipoprotein (oxLDL) induces cellular dysfunction and apoptosis.
Macrophage-mediated cholesterol handling in atherosclerosis.
Orekhov et al., Moscow, Russia. In J Cell Mol Med, Jan 2016
Several scavenger receptors (SR), including CD36, SR-A1 and lectin-like oxLDL receptor-1 (LOX-1), mediate oxLDL uptake.
Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet activation and aggregation.
Chen et al., Taiwan. In Blood, Jan 2016
We hypothesized that plasma L5 levels are increased in acute ischemic stroke patients, and we examined whether lectin-like oxidized LDL receptor-1 (LOX-1), the receptor for L5 on endothelial cells and platelets, plays a critical role in stroke.
Rapamycin Inhibits Oxidized Low Density Lipoprotein Uptake in Human Umbilical Vein Endothelial Cells via mTOR/NF-κB/LOX-1 Pathway.
Xie et al., Suzhou, China. In Plos One, Dec 2015
BACKGROUND: Lectin-like oxidized low-density lipoprotein-1 (LOX-1) is the major receptor for oxidized low density lipoprotein (ox-LDL) uptake in human umbilical vein endothelial cells (HUVECs).
Prenatal hypoxia promotes atherosclerosis via vascular inflammation in the offspring rats.
Xu et al., Suzhou, China. In Atherosclerosis, Dec 2015
RESULTS: We found that TC, LDL-C, ox-LDL-C, and the receptors of ox-LDL-C (lox-1) of the adult offspring were significantly higher than that of the control, while HDL-C was significantly reduced in hypoxia group.
Interplay between CRP, Atherogenic LDL, and LOX-1 and Its Potential Role in the Pathogenesis of Atherosclerosis.
Chen et al., Kao-hsiung, Taiwan. In Clin Chem, Dec 2015
A growing body of evidence has suggested that interplay between CRP, lectin-like oxidized LDL receptor-1 (LOX-1), and atherogenic LDL may underlie the mechanism of endothelial dysfunction that leads to atherosclerosis.
15-Lipoxygenase inhibitors: a patent review.
Jabbari et al., Mashhad, Iran. In Expert Opin Ther Pat, Dec 2015
Two types of the enzyme, 15-LOX-1 and 15-LOX-2, have been recognized in mammals to have different abilities in the peroxidation of arachidonic acid and linoleic acid.
Clinical and Preclinical Use of LOX-1-Specific Antibodies in Diagnostics and Therapeutics.
Homer-Vanniasinkam et al., Leeds, United Kingdom. In J Cardiovasc Transl Res, Nov 2015
Lectin-like oxidized low-density lipoprotein receptor-1 (SR-E1, LOX-1, OLR1) was first discovered as a vascular receptor for modified lipoprotein particles nearly 20 years ago.
The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer.
Xu et al., Zhenjiang, China. In Inflamm Res, Sep 2015
This article reviews and discusses the role of 15-lipoxygenase-1 (15-LOX-1) in the resolution of colitis and prevention of colitis-associated colorectal cancer.
LOX-1 unlocks human plasma cell potential.
Brink, Australia. In Immunity, 2014
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is best known for promoting atherosclerosis.
C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses.
Oh et al., Dallas, United States. In Immunity, 2014
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a pattern-recognition receptor for a variety of endogenous and exogenous ligands.
Cholesterol-lowering drugs inhibit lectin-like oxidized low-density lipoprotein-1 receptor function by membrane raft disruption.
Biocca et al., Roma, Italy. In Mol Pharmacol, 2012
Membrane cholesterol depletion inhibits LOX-1-mediated ox-LDL binding and internalization.
Lectin-like oxidized low-density lipoprotein 1 receptor in a reduced uteroplacental perfusion pressure rat model of preeclampsia.
Davidge et al., Edmonton, Canada. In Hypertension, 2012
In a rat model of preeclampsia, there is dramatic increase in expression levels of both LOX-1 receptor and endothelial NO synthase enzyme, along with increased superoxide production and modestly decreased endothelial function.
Short communication: Association of an OLR1 polymorphism with milk production traits in the Israeli Holstein population.
Khatib et al., China. In J Dairy Sci, 2012
3'-UTR SNP assoicated with milk composition traits and somatic cell score
Pregnancy followed by delivery may affect circulating soluble lectin-like oxidized low-density lipoprotein receptor-1 levels in women of reproductive age.
Baydas et al., Elazığ, Turkey. In Mediators Inflamm, 2011
serum sLOX-1 levels were associated with pregnancy followed by delivery that might predict endothelial dysfunction
Increased lectin-like oxidized LDL receptor-1 expression in the placentas of women with intrahepatic cholestasis during pregnancy.
Wang et al., Ürümqi, China. In Clin Exp Obstet Gynecol, 2011
LOX-1 may play a crucial role in the pathophysiological processes of intrahepatic cholestasis of pregnancy caused by over-apoptosis of trophocytes.
A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases.
Struhl et al., Boston, United States. In Cancer Cell, 2010
As in atherosclerosis, oxidized LDL and its receptor OLR1 activate the inflammatory pathway through NF-kappaB, leading to transformation.
Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors.
Mantovani et al., Saint-Pierre-des-Corps, France. In Immunity, 2005
KpOmpA binds the scavenger receptors (SRs) LOX-1 and SREC-I, but not other members of the same family.
Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation.
Jeannin et al., Saint-Pierre-des-Corps, France. In Immunity, 2002
Scavenger receptors are the main heat-shock-protein binding structures on human dendritic cells and LOX-1 is one of these molecules.
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