Exfoliation syndrome: assembling the puzzle pieces.
Boston, United States. In Acta Ophthalmol, Jan 2016
Lysyl oxidase-like 1 (LOXL1) variants are unequivocally genetic risk factors for XFS but exactly how these variants contribute to the assembly of exfoliation material (XFM) remains unclear.
Outer membrane lipoprotein biogenesis: Lol is not the end.
Princeton, United States. In Philos Trans R Soc Lond B Biol Sci, Nov 2015
Outer membrane (OM) lipoproteins take the localization of lipoproteins (Lol) export pathway, which ends with the insertion of the N-terminal lipid moiety into the inner leaflet of the OM.
Association of Genetic Variants with Polypoidal Choroidal Vasculopathy: A Systematic Review and Updated Meta-analysis.
Hong Kong, Hong Kong. In Ophthalmology, Sep 2015
Another 25 polymorphisms in 13 genes (ARMS2, HTRA1, C2, CFB, ELN, LIPC, LPL, ABCA1, VEGF-A, TLR3, LOXL1, SERPING1, and PEDF) had no significant association.
Elastic fiber homeostasis requires lysyl oxidase-like 1 protein.
Boston, United States. In Nat Genet, 2004
Here we show that mice lacking the protein lysyl oxidase-like 1 (LOXL1) do not deposit normal elastic fibers in the uterine tract post partum and develop pelvic organ prolapse, enlarged airspaces of the lung, loose skin and vascular abnormalities with concomitant tropoelastin accumulation.