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Serine/threonine kinase 10

Lok, STK10, lymphocyte-oriented kinase
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, PAK1, HAD, AGE
Papers on Lok
Comprehensive characterization of the Published Kinase Inhibitor Set.
Zuercher et al., Santa Clara, United States. In Nat Biotechnol, Jan 2016
We identify chemical starting points for designing new chemical probes of orphan kinases and illustrate the utility of these leads by developing a selective inhibitor for the previously untargeted kinases LOK and SLK.
DcR3 suppresses influenza virus-induced macrophage activation and attenuates pulmonary inflammation and lethality.
Hsieh et al., Taipei, Taiwan. In J Mol Med (berl), Oct 2015
Proteome-wide phosphoproteomic mapping revealed that DcR3 not only activated STK10, a negative regulator of cell migration, but also inactivated PKC-α, which are crucial for the activation of ERK and JNK in human macrophages.
Virus-encoded microRNA contributes to the molecular profile of EBV-positive burkitt lymphomas.
Leoncini et al., Bologna, Italy. In Oncotarget, Aug 2015
Among others, we identified LIN28B, CGNL1, GCET2, MRAS, PLCD4, SEL1L, SXX1, and the tyrosine kinases encoding STK10/STK33, all provided with potential pathogenetic significance.
NFKB1/NFKBIa polymorphisms are associated with the progression of cervical carcinoma in HPV-infected postmenopausal women from rural area.
Mausumi et al., India. In Tumour Biol, Aug 2015
In the present study, a total of 575 consecutive subjects including 285 cases (45 cervical pre-cancerous and 240 invasive cervical carcinoma) and 290 age- and ethnicity-matched controls recruited from Lok Nayak Jai Prakash Hospital and Safdarjung Hospital, New Delhi between July 2009 to July 2013 were genotyped for NFKB1 -94 insertion/deletion (rs28362491) and NFKBIa 3'-UTR2758A > G (rs696) polymorphism by PCR-RFLP followed by sequencing.
Newborn screening for G6PD deficiency: A 2-year data from North India.
Kapoor et al., New Delhi, India. In Indian J Public Health, Apr 2015
The study was an observational one, conducted at the Division of Genetics of Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, over a 2-year period from January 2011 to December 2012.
Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis.
Katagiri et al., Sagamihara, Japan. In Nat Commun, 2014
Rap1-GDP associates with and activates lymphocyte-oriented kinase, which phosphorylates ERM (ezrin, radixin and moesin) in resting T cells.
Glutathione S-transferase M1 and T1 Polymorphisms, Cigarette Smoking and HPV Infection in Precancerous and Cancerous Lesions of the Uterine Cervix.
Sharma et al., Delhi, India. In Asian Pac J Cancer Prev, 2014
The study was conducted in Lok Nayak hospital, New Delhi.
Glutathione S-transferase and MRP1 form an integrated system involved in the storage and transport of dinitrosyl-dithiolato iron complexes in cells.
Richardson et al., Sydney, Australia. In Free Radic Biol Med, 2014
USA 103:7670-7675, 2006; H. Lok et al., J. Biol.
A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.
Zaru et al., In Biosci Rep, 2014
We confirmed that these kinases, including Slk, Lok and Mst1, are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.
STK10 missense mutations associated with anti-apoptotic function.
Mano et al., Tokyo, Japan. In Oncol Rep, 2013
One of such substitutions, c.2201G>A in STK10 cDNA, replaces an arginine residue to a histidine (R634H) in the encoded protein.
Correlation of levels of IL-6 with tumor burden and receptor status in patients of locally advanced carcinoma breast.
Gupta et al., Delhi, India. In Indian J Clin Biochem, 2013
This prospective study was conducted by the collaborative efforts of the departments of Surgery and Biochemistry, Maulana Azad Medical College and associated Lok Nayak Hospital and GB Pant Hospitals, New Delhi.
Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.
Bretscher et al., Ithaca, United States. In J Cell Biol, 2013
Proteomic approaches and ribonucleic acid interference knockdown identified lymphocyte-oriented kinase (LOK) and SLK as the relevant kinases.
Variations in the STK10 gene and possible associations with aspirin-intolerant asthma in a Korean population.
Shin et al., Seoul, South Korea. In J Investig Allergol Clin Immunol, 2010
genetic polymorphism is associated with aspirin-intolerant asthma in a Korean population
LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation.
Shaw et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2009
These studies identify a new ERM kinase of importance in lymphocytes and confirm the role of ezrin-radixin-moesin phosphorylation in regulating cell shape and motility.
Liquid movement across the surface epithelium of large airways.
Tarran et al., Chapel Hill, United States. In Respir Physiol Neurobiol, 2008
Science 245, 1073-1080; Riordan, J.R., Rommens, J.M., Kerem, B., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.L., et al., 1989.
Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue.
Hill et al., San Francisco, United States. In J Biol Chem, 2003
Stk10 is a novel polo-like kinase kinase that cooperates with hSlk to regulate Plk1 function in human cells
The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production.
Drachman et al., Seattle, United States. In Oncogene, 2002
Finally, two different strategies using c-mpl lead to the identification of a novel ligand for the receptor in 1994 (de Sauvage et al., 1994; Lok et al., 1994; Bartley et al., 1994), a protein that displays all the biologic properties of TPO.
Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells.
August et al., United States. In Biochem J, 2002
Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells
Recent advances in the molecular analysis of inherited disease.
Malcolm, London, United Kingdom. In Eur J Biochem, 1991
Important examples include the dystrophin protein which, when mutated, gives rise to either Duchenne or Becker muscular dystrophy [Koenig, M., Hoffman, E. P., Bertelson, C. J., Monaco, A. P., Feener, C. and Kunkel, L. M. (1987) Cell 50, 509-517; Monaco, A. P., Bertelson, C. J., Liechti-Gallati, S. & Kunkel, L. M. (1988) Genomics 2, 90-95; Koenig, M., Monaco, A. P. & Kunkel, L. M. (1988) Cell 53, 219-228] and the cystic fibrosis transmembrane conductance regulator (CFTR) [Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., Drumm, M. L., Ianuzzi, M. C., Collins, F. S. & Tsui, L.-C. (1989) Science 245, 1066-1073].
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