gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Serine/threonine kinase 11

LKB1, PAR-4, STK11
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: AMPK, V1a, CAN, HAD, p53
Papers using LKB1 antibodies
Molecular mechanisms involved in Sertoli cell adaptation to glucose deprivation.
Lobaccaro Jean-Marc A., In PLoS ONE, 2008
... Mouse anti-LKB1 monoclonal antibody (Ley37 D/G6), which recognizes both splice variants of LKB1, was from Santa Cruz Biotechnology.
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis.
Gottardi Cara, In PLoS ONE, 2007
... Antibodies for Western blotting included anti-LKB1 (clone D60C5, Cell Signaling Technology, Danvers, MA, USA) ...
Dynamic FoxO transcription factors
Mao Zebin et al., In International Journal of Molecular Sciences, 2006
... Antibodies against p70S6K (Thr389), p4E-BP1 (Thr37/46), pAkt (Thr308), pTSC2 (Thr1462), pAMPK-α (Thr172), LKB1 and pACC (Ser79) were purchased from Cell Signaling Technology, Inc ...
Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal
Tang Chih-Hsin et al., In Arthritis Research & Therapy, 2003
... for thrombin, PAR1, PAR3, PAR4, c-Src, PKCδ, and Nrf2, and siRNA against PAR1, PAR3, and PAR4 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome.
Tsuji Yoshiaki, In PLoS ONE, 1996
... Mouse monoclonal anti-LKB1 (ab15095) was obtained from Abcam, rabbit monoclonal anti-phospho-AMPKα Thr172 ...
more suppliers
Papers on LKB1
Panel Testing for Familial Breast Cancer: Calibrating the Tension Between Research and Clinical Care.
Campbell et al., Newcastle, Australia. In J Clin Oncol, Feb 2016
A significant excess of mutations was only observed for PALB2 (26 cases, four controls) and TP53 (five cases, zero controls), whereas no mutations were identified in STK11.
A Phase I Trial of Temsirolimus and Pemetrexed in Patients with Advanced Non-Small Cell Lung Cancer.
Govindan et al., In Chemotherapy, Feb 2016
This combination may be further evaluated in patients with mTOR pathway activation, particularly in those with TSC1 or STK11 mutations.
Antiaging Gene Klotho Deficiency Promoted High-Fat Diet-Induced Arterial Stiffening via Inactivation of AMP-Activated Protein Kinase.
Sun et al., United States. In Hypertension, Feb 2016
In cultured mouse aortic smooth muscle cells, cholesterol plus KL-deficient serum decreased phosphorylation levels of AMPKα and LKB1 (an important upstream regulator of AMPKα activity) but increased collagen I synthesis, which can be eliminated by activation of AMPKα by 5-aminoimidazole-4-carboxamide-3-ribonucleoside.
Betulin alleviated ethanol-induced alcoholic liver injury via SIRT1/AMPK signaling pathway.
Nan et al., Yanji, China. In Pharmacol Res, Feb 2016
In vitro results showed that betulin effectively decreased LX-2 cell viability, attenuated collagen-I, α-smooth muscle actin (α-SMA) levels, activated liver kinase B-1 (LKB1) and adenosine monophosphate-activated protein kinase (AMPK) phosphorylation.
Retrospective multicentre study investigating the role of targeted next-generation sequencing of selected cancer genes in mucinous adenocarcinoma of the lung.
Papotti et al., Torino, Italy. In J Thorac Oncol, Feb 2016
The majority of mutations clustered in the MAP-AKT kinase (KRAS, PIK3CA, STK11, PTEN, AKT1, HRAS, BRAF) and the p53/DNA repair (TP53, CDKN2A, ATM, RB1) pathways.
Clinically advanced and metastatic pure mucinous carcinoma of the breast: a comprehensive genomic profiling study.
Stephens et al., Albany, United States. In Breast Cancer Res Treat, Feb 2016
CRGA were also found in 20 additional genes including PIK3CA (5), BRCA1 (1), TSC2 (1), STK11 (1), AKT3 (1), and ESR1 (1).
Metformin and pancreatic cancer: Is there a role?
Saif et al., Boston, United States. In Cancer Chemother Pharmacol, Feb 2016
Metformin influences various cellular pathways, including activation of the LKB1/AMPK pathway, inhibition of cell division, promotion of apoptosis and autophagy, down-regulation of circulating insulin, and activation of the immune system.
Control of YAP/TAZ Activity by Metabolic and Nutrient-Sensing Pathways.
Dupont et al., Padova, Italy. In Trends Cell Biol, Jan 2016
The activity of the YAP/TAZ transcriptional coactivators, downstream transducers of the Hippo cascade and powerful pro-oncogenic factors, was recently found to be regulated by metabolic pathways, such as aerobic glycolysis and mevalonate synthesis, and by the nutrient-sensing LKB1-AMPK and TSC-mTOR pathways.
The diverse oncogenic and tumor suppressor roles of salt-inducible kinase (SIK) in cancer.
Pei et al., Xuzhou, China. In Expert Opin Ther Targets, Dec 2015
Expert opinion: It is conceivable that SIKs, mainly stimulated by ACTH, LKB1, TGF-β, and autophosphorylation, play crucial roles in regulating multiple signal pathways in cancer cells and controlling a series of cellular processes including cell proliferation and cell apoptosis.
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Chen et al., Atlanta, United States. In Nat Cell Biol, Nov 2015
6PGD-mediated production of ribulose-5-phosphate (Ru-5-P) inhibits AMPK activation by disrupting the active LKB1 complex, thereby activating acetyl-CoA carboxylase 1 and lipogenesis.
Genetic risk assessment and prevention: the role of genetic testing panels in breast cancer.
Narod et al., Toronto, Canada. In Expert Rev Anticancer Ther, Nov 2015
Across all gene panel studies, the prevalence of pathogenic mutations was highest in BRCA1 (5.3%) and BRCA2 (3.6%) and was lowest in PTEN (0.1%), CDH1 (0.1%) and STK11 (0.01%).
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
Klein et al., Baltimore, United States. In Nat Genet, Aug 2015
5), STK11 (ref.
Next-Generation Sequencing of Pulmonary Sarcomatoid Carcinoma Reveals High Frequency of Actionable MET Gene Mutations.
Borczuk et al., Guangzhou, China. In J Clin Oncol, Aug 2015
RESULTS: In addition to confirming mutations in known cancer-associated genes (TP53, KRAS, PIK3CA, MET, NOTCH, STK11, and RB1), several novel mutations in additional genes, including RASA1, CDH4, CDH7, LAMB4, SCAF1, and LMTK2, were identified and validated.
LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response.
Ji et al., Shanghai, China. In Cancer Cell, Jun 2015
LKB1 regulates both cell growth and energy metabolism.
Cell Death Conversion under Hypoxic Condition in Tumor Development and Therapy.
Ji et al., Jinan, China. In Int J Mol Sci, 2014
On the one hand, the metabolic and oxidative stress following hypoxia could lead to cell death by triggering signal cascades, like LKB1/AMPK, PI3K/AKT/mTOR, and altering the levels of effective components, such as the Bcl-2 family, Atg and p62.
Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.
Martínez-Chantar et al., Spain. In Gastroenterology, 2012
Reduced expression of GNMT in mouse hepatoma cells appears to increase the activity of LKB1/RAS signaling.
LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma.
Sharpless et al., Chapel Hill, United States. In Cancer Cell, 2012
Results suggest that LKB1 inactivation in the context of RAS activation facilitates metastasis by inducing an SFK-dependent expansion of a prometastatic, CD24(+) tumor subpopulation.
RAGE signaling mediates post-injury arterial neointima formation by suppression of liver kinase B1 and AMPK activity.
Terkeltaub et al., San Diego, United States. In Atherosclerosis, 2012
Decreased LKB1/AMPK activity and increased STAT3 in vascular smooth muscle mediates the capacity of RAGE ligand-induced signaling to promote neointima formation in response to arterial injury.
Not all fat is equal: differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer.
Hoehn et al., Charlottesville, United States. In Int J Gynecol Cancer, 2012
Loss of Liver kinase B1 is associated with endometrial cancer.
14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function.
Huang et al., Hefei, China. In Febs Lett, 2012
autophosphorylation of Thr336 acts as an activating signal for LKB1 to recruit 14-3-3, which in turn attenuates the activation of LKB1 to keep the activity of LKB1 in check.
More papers using LKB1 antibodies
Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell–derived neural transplants
Condie Brian G. et al., In The Journal of Cell Biology, 1995
... IgG, polyclonal anti–α-fetoprotein rabbit IgG, polyclonal anti-PAR-4 rabbit IgG, polyclonal anti-PAR-4 goat IgG, and monoclonal anti-PAR-4 mouse IgG were purchased from Santa Cruz Biotechnology, Inc ...
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
Khanin Raya, In PLoS ONE, 1975
... Mouse monoclonal anti-LKB1 (ab15095) was purchased from Abcam, rabbit monoclonal anti-phospho-AMPKα Thr172 ...
share on facebooktweetadd +1mail to friends