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Protein tyrosine phosphatase, receptor type, f polypeptide

liprin-alpha2, PPFIA2
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein is most closely related to PPFIA1, a liprin family member known to interact with the protein phosphatase LAR. The expression of this gene is found to be downregulated by androgens in a prostate cancer cell line. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: LAR, HAD, McA, FACT, MUC4
Papers on liprin-alpha2
SNP array screening of cryptic genomic imbalances in 450 Japanese subjects with intellectual disability and multiple congenital anomalies previously negative for large rearrangements.
Inazawa et al., Tokyo, Japan. In J Hum Genet, Feb 2016
Among the 22 cases, we identified PPFIA2 as a novel candidate gene for ID.
Identification of a Candidate Gene Panel for the Early Diagnosis of Prostate Cancer.
Schalken et al., Nijmegen, Netherlands. In Clin Cancer Res, Aug 2015
After quantitative PCR analysis on tissue specimens and urinary sediments, eight promising biomarkers for the urinary detection of prostate cancer were selected (ONECUT2, HOXC4, HOXC6, DLX1, TDRD1, NKAIN1, MS4A8B, PPFIA2).
Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2.
Young et al., Durham, United States. In Invest Ophthalmol Vis Sci, 2013
Quantitative testing determined statistically significant SNPs rs4764971, also found by qualitative testing (P = 3.1 × 10(-6)); rs7134216, in the 3' untranslated region (UTR) of DEPDC4 (P = 5.4 × 10(-7)); and rs17306116, an intronic SNP within PPFIA2 (P < 9 × 10(-4)).
Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures.
Zhang et al., Hong Kong, Hong Kong. In Mol Cell, 2011
Liprins can mediate assembly of target proteins into large protein complexes capable of regulating numerous cellular activities.
Identification and characterization of human PPFIA4 gene in silico.
Katoh et al., Narashino, Japan. In Int J Mol Med, 2003
was paralogous to PPFIA2-LIN7A-MYF5-MYF6 locus (12q21.31),
Liprin-alpha2 gene, protein tyrosine phosphatase LAR interacting protein related gene, is downregulated by androgens in the human prostate cancer cell line LNCaP.
Kubota et al., Yokohama, Japan. In Int J Mol Med, 2002
Liprin-alpha2 expression is downregulated by androgens in prostate cancer cells. It might play a role in androgen-responsive human prostate cancer & the loss of this gene expression might be associated with the androgen-independence.
Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.
Streuli et al., Boston, United States. In J Biol Chem, 1998
Co-expression studies indicate that liprin-alpha2 alters LAR cellular localization and induces LAR clustering.
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