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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Lin-28 homolog B

LIN28B, lin-28 homolog B
Top mentioned proteins: Lin28, AGE, miR, c-Myc, CAN
Papers on LIN28B
miR-26a suppresses EMT by disrupting the Lin28B/let-7d axis: potential cross-talks among miRNAs in IPF.
Shan et al., Harbin, China. In J Mol Med (berl), Feb 2016
In this study, we found that Lin28B could induce the process of epithelial-mesenchymal transition (EMT) by inhibiting let-7d, whereas inhibition of Lin28B mitigated TGF-β1-induced fibrogenesis and attenuated EMT in both cultured A549 cells and MLE-12 cells.
The bromodomain inhibitor JQ1 and the histone deacetylase inhibitor panobinostat synergistically reduce N-Myc expression and induce anticancer effects.
Liu et al., Australia. In Clin Cancer Res, Feb 2016
Modulation of LIN28B promoter activity by BRD3 and BRD4 was examined by chromatin immunoprecipitation and luciferase assays.
LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia.
De Moerloose et al., Gent, Belgium. In Blood, Jan 2016
Using gene expression profiling in a series of 82 patient samples, we aimed at understanding the molecular biology behind JMML and identified a previously unrecognized molecular subgroup characterized by high LIN28B expression.
Sex-specific regulation of weight and puberty by the Lin28/let-7 axis.
Palmert et al., Boston, United States. In J Endocrinol, Jan 2016
Variants in/near LIN28B associate with age at menarche (AAM) in genome-wide association studies and some AAM-related variants associate with growth in a sex-specific manner.
Lin28 - a stem cells factor with a key role in pediatric tumor formation.
Urbach et al., Ramat Gan, Israel. In Stem Cells Dev, Jan 2016
Lin28A and its paralog Lin28B are pluripotent genes that are expressed mainly in stem/progenitor cells.
Let-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells.
Vento et al., Palermo, Italy. In J Cell Physiol, Jan 2016
Let-7d also decreased sarcosphere-and-colony forming ability, two features associated with self-renewing, and it reduced the expression of stemness genes, including Oct3/4, Sox2, Nanog, Lin28B and HMGA2.
A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis.
Diskin et al., Philadelphia, United States. In Cancer Cell, Dec 2015
Recently, we identified LIN28B as an oncogenic driver in high-risk neuroblastoma.
SET7/9 methylation of the pluripotency factor LIN28A is a nucleolar localization mechanism that blocks let-7 biogenesis in human ESCs.
Lee et al., Taejŏn, South Korea. In Cell Stem Cell, 2015
LIN28A is believed to act primarily in the cytoplasm together with TUT4/7 to prevent final maturation of let-7 by Dicer, whereas LIN28B has been suggested to preferentially act on nuclear processing of let-7.
Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer.
Li et al., Harbin, China. In Mol Cancer, 2014
The RBP LIN28A/LIN28B, a direct target of the let-7 family of miRNAs, is an inhibitor of let-7 biogenesis and is frequently up-regulated in cancers.
Recent insights into the biology of neuroblastoma.
Delattre et al., Paris, France. In Int J Cancer, 2014
The identification of major players in NB oncogenesis, including MYCN, ALK, PHOX2B and LIN28B, has enabled the development of new animal models.
Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models.
Zhu et al., Dallas, United States. In Cancer Cell, 2014
We report that LIN28B overexpression is sufficient to initiate hepatoblastoma and hepatocellular carcinoma in murine models.
Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing.
Lichter et al., Heidelberg, Germany. In Nature, 2014
Epigenetic alterations also affected novel medulloblastoma candidate genes (for example, LIN28B), resulting in alternative promoter usage and/or differential messenger RNA/microRNA expression.
Epigenetic interventions increase the radiation sensitivity of cancer cells.
Jiang et al., Xi'an, China. In Curr Pharm Des, 2013
Inhibition of miR-34 expression or function, downregulation of miR-155, upregulation of miR-18a, Overexpression let-7g or knocking down LIN28B, and ectopically overexpressed miR-10 in cells with low endogenous miR-101 level increase the response of cells to irradiation.
MYCN/LIN28B/Let-7/HMGA2 pathway implicated by meta-analysis of GWAS in suppression of post-natal proliferation thereby potentially contributing to aging.
de Magalhães et al., Liverpool, United Kingdom. In Mech Ageing Dev, 2013
A meta-analysis of genome-wide association studies using growth and development-related traits revealed that two genes, HMGA2 and LIN28B, had multiple associations.
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.
Schulte et al., Amsterdam, Netherlands. In Nat Genet, 2012
LIN28B regulates developmental processes by modulating microRNAs (miRNAs) of the let-7 family.
Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma.
Aplan et al., Bethesda, United States. In Blood, 2012
Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma.
High expression of Lin28 is associated with tumour aggressiveness and poor prognosis of patients in oesophagus cancer.
Doki et al., Suita, Japan. In Br J Cancer, 2012
High expression of Lin28B correlated significantly with lymph node metastasis and poor prognosis. High expression of Lin28B expression correlated significantly with low expression of let-7.
Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis.
Muljo et al., Bethesda, United States. In Science, 2012
study reports Lin28b is expressed in fetal liver and thymus, but not adult bone marrow or thymus; ectopic expression of Lin28 reprograms hematopoietic progenitor cells from adult bone marrow, endowing them with ability to mediate fetal-like lymphopoiesis
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.
Gregory et al., Boston, United States. In Cell, 2011
Unlike Lin28A, Lin28B represses let-7 processing through a Zcchc11-independent mechanism; Lin28B functions in the nucleus by sequestering primary let-7 transcripts and inhibiting their processing by the Microprocessor.
[Effects of Lin28a and Lin28b on let-7 family activity].
Wu et al., Wenzhou, China. In Bing Du Xue Bao, 2011
Both HeLaS3/pAAV2neo-Lin28a and HeLaS3/pAAV2neo-Lin28b could express Lin28a and Lin28b effectively.
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