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Lck interacting transmembrane adaptor 1

LIME, Lck-interacting membrane protein
LIME1 is a raft-associated transmembrane adaptor phosphoprotein that is preferentially expressed in hemopoietic cells, particularly T cells (Brdickova et al., 2003 [PubMed 14610046]; Hur et al., 2003 [PubMed 14610044]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: LAT, Src, Lck, Csk, Grb2
Papers using LIME antibodies
Hořejší Václav et al., In The Journal of Experimental Medicine, 1993
... Antiserum to LIME was produced in the Prague laboratory by immunization of rabbits with bacterially expressed and Talon purified (CLONTECH Laboratories, Inc.) cytoplasmic fragment ...
Papers on LIME
Modeling nanoparticle wrapping or translocation in bilayer membranes.
Hall et al., Raleigh, United States. In Nanoscale, Oct 2015
By combining LIME, an intermediate resolution, implicit solvent model for phospholipids, with discontinuous molecular dynamics (DMD), we are able to simulate the wrapping or embedding of nanoparticles by 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) bilayer membranes.
Palmitoylated transmembrane adaptor proteins in leukocyte signaling.
Horejsi et al., Praha, Czech Republic. In Cell Signal, 2014
Several TRAPs (LAT, NTAL, PAG, LIME, PRR7, SCIMP, LST1/A, and putatively GAPT) are known to be palmitoylated that could facilitate their localization in lipid rafts or tetraspanin enriched microdomains.
The transmembrane adaptor protein, linker for activation of T cells (LAT), regulates RANKL-induced osteoclast differentiation.
Kim et al., Kwangju, South Korea. In Mol Cells, 2012
LAT positively regulates osteoclast differentiation and is up-regulated by RANKL via c-Fos and NFATc1, whereas LAB and LIME act as negative modulators of osteoclastogenesis.
LIME mediates immunological synapse formation through activation of VAV.
Yun et al., Seoul, South Korea. In Mol Cells, 2012
these results establish LIME as a transmembrane adaptor protein linking TCR stimulation to IS formation and integrin activation through activation of Vav(Vav guanine nucleotide exchange factor)
Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected epithelial cells.
Naumann et al., Magdeburg, Germany. In Cell Signal, 2010
Investigating DRM-associated molecules we identified the transmembrane adapter proteins (TRAPs), non-T cell activation linker (NTAL) and lymphocyte-specific protein tyrosine kinase (Lck)-interacting membrane protein (LIME) to be regulated by H. pylori in the human epithelial cell line HCA-7.
Transmembrane adaptor proteins positively regulating the activation of lymphocytes.
Yun et al., Seoul, South Korea. In Immune Netw, 2009
Among seven TRAPs identified so far, LAT and LIME were shown to act as a positive regulator in TCR-mediated signaling pathways.
Adaptor molecules expression in normal lymphopoiesis and in childhood leukemia.
Zuna et al., Praha, Czech Republic. In Immunol Lett, 2009
The aim of this study was to characterize expression of PAG, LAT, NTAL and LIME adaptors at the mRNA and protein levels in normal B- and T-precursors.
Deletion of the LIME adaptor protein minimally affects T and B cell development and function.
Malissen et al., Marseille, France. In Eur J Immunol, 2007
LIME (Lck-interacting membrane protein) is a transmembrane adaptor that associates with the Lck and Fyn protein tyrosine kinases and with the C-terminal Src kinase (Csk).
LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.
Yun et al., Seoul, South Korea. In Blood, 2006
LIME is an essential transmembrane adaptor linking B-cell receptor ligation to the downstream signaling events that lead to B-cell activation.
Transmembrane adaptor molecules: a new category of lymphoid-cell markers.
Horejsí et al., Oxford, United Kingdom. In Blood, 2006
In this paper, we report an immunohistologic study of 6 of these molecules in normal and neoplastic human tissue sections and show that they are restricted to subpopulations of lymphoid cells, being present in either T cells (LAT, LIME, and TRIM), B cells (NTAL), or subsets of both cell types (PAG and SIT).
A fast and sensitive method for isolation of detergent-resistant membranes from T cells.
Carlson et al., Oslo, Norway. In J Immunol Methods, 2005
The method, which can be completed in 6 h, yields more than 80% of the total content of DRM-associated adaptor molecules LAT (linker for T cell activation), PAG/Cbp (protein associated with glycosphingolipid-enriched microdomains or Csk-binding protein) and LIME (Lck-interacting membrane protein) in low-density fractions using only 2x10(7) T cells.
Adaptors and linkers in T and B cells.
Schraven et al., Magdeburg, Germany. In Curr Opin Immunol, 2004
Additional transmembrane adaptors, such as NTAL/LAB and LIME, have been identified and partially characterized.
Transmembrane adaptor proteins in membrane microdomains: important regulators of immunoreceptor signaling.
Horejsí, Praha, Czech Republic. In Immunol Lett, 2004
Most transmembrane proteins are excluded from these specialized areas of membranes, notable exceptions being several palmitoylated proteins such as the T cell coreceptors CD4 and CD8, and several recently described transmembrane adaptor proteins, LAT, non-T cell activation linker (NTAL)/linker for activation of B cells (LAB), phosphoprotein associated with GEMs (PAG)/Csk-binding protein (Cbp) and LIME.
LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.
Horejsí et al., Praha, Czech Republic. In J Exp Med, 2003
Here, we report identification of a new raft-associated adaptor protein LIME (Lck-interacting molecule) expressed predominantly in T lymphocytes.
LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation.
Yun et al., Seoul, South Korea. In J Exp Med, 2003
In this study, we identify and characterize a novel transmembrane adaptor protein, designated Lck-interacting membrane protein (LIME), as a binding partner of the Lck Src homology (SH)2 domain.
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