gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Leukocyte immunoglobulin-like receptor, subfamily A

Sponsored links
Top mentioned proteins: LIR, MHC, HLA-B, CAN, ACID
Papers on LILRA1
Functional and genetic diversity of leukocyte immunoglobulin-like receptor and implication for disease associations.
Arase et al., Ōsaka, Japan. In J Hum Genet, Nov 2015
Human leukocyte immunoglobulin-like receptors (LILR) are a family of 11 functional genes encoding five activating (LILRA1, 2, 4-6), five inhibitory (LILRB1-5) and one soluble (LILRA3) form.
Expression of B-cell-associated genes in peripheral blood mononuclear cells of patients with symptomatic pulmonary embolism.
Song et al., Shanghai, China. In Mol Med Report, Mar 2015
LILRA1 and TLR9 T cell‑independent B‑cell activation mRNAs were significantly upregulated in PE patients compared with those of the control group.
The Leukocyte Immunoglobulin-Like Receptor Family Member LILRB5 Binds to HLA-Class I Heavy Chains.
Kollnberger et al., Oxford, United Kingdom. In Plos One, 2014
We screened for LILR binding to HLA-class I by tetramer staining of 293T cells transfected with LILRA1, A4, A5 A6 and LILRB2 and LILRB5.
Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence.
Liu et al., Johnson City, United States. In J Mol Neurosci, 2012
Interestingly, several genes (TESK2, TIPARP, THEMIS, ABLIM1, RFX4, STON2 and LILRA1) are associated with three personality traits with p < 10(-3) using single trait analysis and AD.
Expression of activating and inhibitory leukocyte immunoglobulin-like receptors in rheumatoid synovium: correlations to disease activity.
McNeil et al., Sydney, Australia. In Tissue Antigens, 2011
In contrast, LILRA1 and B4 were expressed in a subset of patients and no B1 or B5 expression was detected.
HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding.
Allen et al., Cambridge, United Kingdom. In J Immunol, 2011
In contrast, the activating receptor LILRA1 and the soluble LILRA3 protein displayed a preference for binding to HLA-C free H chain.
LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence.
Gao et al., Beijing, China. In Plos One, 2010
As one of the Group 1 LILRs, LILRA3 is the only secretory LILR and may greatly control the inhibitory immune response induced by LILRB1, LILRB2, and other HLA-binding LILR molecules like LILRA1.
Soluble LILRA3, a potential natural antiinflammatory protein, is increased in patients with rheumatoid arthritis and is tightly regulated by interleukin 10, tumor necrosis factor-alpha, and interferon-gamma.
Tedla et al., Sydney, Australia. In J Rheumatol, 2010
LILRA3 has high homology to activating LILRA1 and A2, hence may act as a soluble agonist/antagonist to these receptors.
Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes.
Gao et al., Beijing, China. In J Mol Biol, 2009
LILRB1 (ILT2), LILRB2 (ILT4) and LILRA1 (LIR6) can recognize MHC (major histocompatibility complex) class I or class I-like molecules, and LILRB1/HLA-A2, LILRB1/UL18 and LILRB2/HLA-G complex (extracellular domains D1D2) structures have been solved recently.
Association of LILRA2 (ILT1, LIR7) splice site polymorphism with systemic lupus erythematosus and microscopic polyangiitis.
Tsuchiya et al., Tokyo, Japan. In Genes Immun, 2008
In this study, we examined the association of LILRA2 and adjacently located LILRA1 with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and microscopic polyangiitis (MPA).
Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells.
Arm et al., Sydney, Australia. In J Leukoc Biol, 2008
Progenitor mast cells expressed cell surface inhibitory LILRB1, -B2, -B3, and -B4 and activating LILRA1.
Ixodes ricinus tick lipocalins: identification, cloning, phylogenetic analysis and biochemical characterization.
Godfroid et al., Brussels, Belgium. In Plos One, 2007
Finally, we demonstrated that LIR6 codes for a protein that specifically binds leukotriene B4.
Killer cell Ig-like receptor and leukocyte Ig-like receptor transgenic mice exhibit tissue- and cell-specific transgene expression.
Trowsdale et al., Cambridge, United Kingdom. In J Immunol, 2003
To generate an experimental model for exploring the function, expression pattern, and developmental regulation of human Ig-like activating and inhibitory receptors, we have generated transgenic mice using two human genomic clones: 52N12 (a 150-Kb clone encompassing the leukocyte Ig-like receptor (LILR)B1 (ILT2), LILRB4 (ILT3), and LILRA1 (LIR6) genes) and 1060P11 (a 160-Kb clone that contains ten killer cell Ig-like receptor (KIR) genes).
Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures.
Wilson et al., Cambridge, United Kingdom. In J Immunol, 2001
Classical complexes bound ILT2, ILT4, and LIR6 transfectants but not ILT1, ILT3, or ILT5.
Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4.
Arm et al., Boston, United States. In Immunogenetics, 2000
We describe the organization and fine localization of the genes for LIR-1 and LIR-5, which are inhibitory receptors, and LIR-6, which is an activating receptor.
share on facebooktweetadd +1mail to friends