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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

LIM homeobox protein 5

Lhx5, lim5
LIM homeobox transcription factor; may be involved in the topographic organization of motor neurons [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: LIM, Lim1, Lhx9, Pax6, TTF-1
Papers on Lhx5
Control of axon guidance and neurotransmitter phenotype of dB1 hindbrain interneurons by Lim-HD code.
Sela-Donenfeld et al., Jerusalem, Israel. In J Neurosci, Mar 2015
dB1 interneurons express various transcription factors (TFs): the pancreatic transcription factor 1a (Ptf1a), the homeobox TF-Lbx1 and the Lim-homeodomain (Lim-HD), and TF Lhx1 and Lhx5.
Conserved Noncoding Sequences Regulate lhx5 Expression in the Zebrafish Forebrain.
Peng et al., Shanghai, China. In Plos One, 2014
The LIM homeobox family protein Lhx5 plays important roles in forebrain development in the vertebrates.
LIM homeobox protein 5 (Lhx5) is essential for mamillary body development.
Varela-Echavarría et al., Mexico. In Front Neuroanat, 2014
Here we demonstrate that Lhx5, a LIM-HD domain transcription factor expressed early in the developing posterior hypothalamus, is required for the generation of the MM and its derived tracts.
Lhx5 controls mamillary differentiation in the developing hypothalamus of the mouse.
Alvarez-Bolado et al., Heidelberg, Germany. In Front Neuroanat, 2014
To clarify how MBO identity is acquired after regional specification, we investigated Lhx5, a transcription factor with restricted MBO expression.
Combinatorial expression of Lef1, Lhx2, Lhx5, Lhx9, Lmo3, Lmo4, and Prox1 helps to identify comparable subdivisions in the developing hippocampal formation of mouse and chicken.
Medina et al., Lleida, Spain. In Front Neuroanat, 2013
We carried out a study of the expression patterns of seven developmental regulatory genes (Lef1, Lhx2, Lhx9, Lhx5, Lmo3, Lmo4, and Prox1), in combination with topological position, to identify the medial pallial derivatives, define its major subdivisions, and compare them between mouse and chicken.
The olfactory amygdala in amniotes: an evo-devo approach.
Medina et al., Lleida, Spain. In Anat Rec (hoboken), 2013
Lhx6, Shh, Tbr1, Lhx9, Lhx5, Otp, and Pax6) in embryos of mouse, chicken, emydid turtles, and a pipid frog.
The expression of LIM-homeobox genes, Lhx1 and Lhx5, in the forebrain is essential for neural retina differentiation.
Ohuchi et al., Okayama, Japan. In Dev Growth Differ, 2013
We have previously shown that overexpression of Lhx1 and Lhx5, members of the LIM-homeobox genes, induced the formation of a second neural retina from the presumptive pigmented retina of the OV.
Lhx1 in the proximal region of the optic vesicle permits neural retina development in the chicken.
Ohuchi et al., Tokushima, Japan. In Biol Open, 2012
Lhx2, another LIM-homeobox gene supposed to be involved in early OV formation, could not substitute this function of Lhx1, while Lhx5, closely related to Lhx1, could replace it.
DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables.
Hicks et al., United States. In Mol Oncol, 2011
Furthermore, analysis of these tumors by using follow-up survival data identified differential methylation of islands proximal to genes involved in Cell Cycle and Proliferation (Ki-67, UBE2C, KIF2C, HDAC4), angiogenesis (VEGF, BTG1, KLF5), cell fate commitment (SPRY1, OLIG2, LHX2 and LHX5) as having prognostic value independent of subtypes and other clinical factors.
Contribution of genoarchitecture to understanding forebrain evolution and development, with particular emphasis on the amygdala.
Abellán et al., Lleida, Spain. In Brain Behav Evol, 2010
In all tetrapods studied, the amygdala includes at least 4 components: (1) a ventral pallial part, characterized by expression of Lhx2 and Lhx9, that includes part of the basal amygdalar complex in mammals and a caudal part of the dorsal ventricular ridge in sauropsids and also produces a cell subpopulation of the medial amygdala; (2) a striatal part, characterized by expression of Pax6 and/or Islet1, which includes the central amygdala in different species; (3) a pallidal part, characterized by expression of Nkx2.1 and, in amniotes, Lhx6, which includes part of the medial amygdala, and (4) a hypothalamic part (derived from the supraoptoparaventricular domain or SPV), characterized by Otp and/or Lhx5 expression, which produces an important subpopulation of cells of the medial extended amygdala (medial amygdala and/or medial bed nucleus of the stria terminalis).
Directed neural differentiation of mouse embryonic stem cells is a sensitive system for the identification of novel Hox gene effectors.
Gouti et al., Athens, Greece. In Plos One, 2010
We show that Hoxb1 acts as an activator to establish the full expression domain of CRABPI and II in rhombomere 4 and as a repressor to restrict expression of Lhx5 and Lhx9.
Similarities and differences in the forebrain expression of Lhx1 and Lhx5 between chicken and mouse: Insights for understanding telencephalic development and evolution.
Medina et al., Lleida, Spain. In J Comp Neurol, 2010
We compared expression of the paralogous LIM-homeodomain genes Lhx1 and Lhx5 in the developing rostral forebrain of mouse and chicken.
LIM-homeobox gene Lhx5 is required for normal development of Cajal-Retzius cells.
Zhao et al., Querétaro, Mexico. In J Neurosci, 2010
These results reveal a complex role for Lhx5 in regulating the development and normal distribution of Cajal-Retzius cells in the developing forebrain.
Diverse expression patterns of LIM-homeodomain transcription factors (LIM-HDs) in mammalian inner ear development.
Chen et al., Boston, United States. In Dev Dyn, 2008
The second wave of expression at E12.5 includes Lhx3, 5, 9, Isl2, and Lmx1b in the differentiating sensory epithelia with cellular specificities.
LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum.
Westphal et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2007
Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum.
Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord.
Goulding et al., San Diego, United States. In Development, 2007
Lhx1 and Lhx5 function together with Pax2, Pax5 and Pax8 to establish a GABAergic inhibitory-neurotransmitter program in dorsal horn interneurons.
Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists.
Westerfield et al., Eugene, United States. In Development, 2006
Lhx5 is a required factor that promotes forebrain development and inhibits Wnt signaling by activating the transcription of secreted Wnt antagonists.
Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5.
Westphal et al., Bethesda, United States. In Science, 1999
In mice, this protein is essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development.
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