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Relaxin/insulin-like family peptide receptor 1

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: Insulin, INSL3, GPCR135, CAN, HAD
Papers on LGR7
A single adenovirus-mediated relaxin delivery attenuates established liver fibrosis in rats.
Lee et al., Seoul, South Korea. In J Gene Med, Feb 2016
While the liver and serum RLX levels were elevated on day 3 and reversed by week 3, expression of RLX receptor (Rxfp1, Relaxin-like family peptide receptor-1), in TAA+RLX rats was sustained to be elevated.
Application of the novel bioluminescent ligand-receptor binding assay to relaxin-RXFP1 system for interaction studies.
Guo et al., Shanghai, China. In Amino Acids, Feb 2016
UNASSIGNED: Relaxin is a prototype of the relaxin family peptide hormones and plays important biological functions by binding and activating the G protein-coupled receptor RXFP1.
Endometrial LGR7 expression and implantation failure.
De Franciscis et al., Napoli, Italy. In Gynecol Endocrinol, Feb 2016
In a prospective observational study, the endometrial RLX receptor (LGR7) expression was assessed in three groups of patients with regular ovulatory cycle and normal uterine cavity: 23 with RPL (Group A), 23 with unexplained infertility undergone at least three cycles of failed in vitro fertilization (IVF) reporting good oocyte and embryo quality (Group B), 23 with proven fertility (Group C).
Native Chemical Ligation to Minimize Aspartimide Formation during Chemical Synthesis of Small LDLa Protein.
Hossain et al., Melbourne, Australia. In Chemistry, Jan 2016
The inhibition of the G protein-coupled receptor, relaxin family peptide receptor 1 (RXFP1), by a small LDLa protein may be a potential approach for prostate cancer treatment.
Relaxin in paraventricular nucleus contributes to sympathetic overdrive and hypertension via PI3K-Akt pathway.
Zhu et al., Nanjing, China. In Neuropharmacology, Jan 2016
Relaxin and its RXFP1 receptors in PVN were up-regulated in SHR.
Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimer's disease patients.
Lai et al., Singapore, Singapore. In Psychopharmacology (berl), Dec 2015
RATIONALE: The G-protein-coupled relaxin family receptors RXFP1 and RXFP3 are widely expressed in the cortex and are involved in stress responses and memory and emotional processing.
Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells.
Summers et al., Australia. In Br J Pharmacol, Nov 2015
This was not observed in human umbilical artery endothelial cells (HUAECs) that do not express RXFP1.
The relaxin family peptide receptors and their ligands: new developments and paradigms in the evolution from jawless fish to mammals.
Good et al., Winnipeg, Canada. In Gen Comp Endocrinol, 2015
Most placental mammals harbour genes for four receptors, namely rxfp1, rxfp2, rxfp3 and rxfp4.
RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer.
Klonisch et al., Winnipeg, Canada. In Front Endocrinol (lausanne), 2014
Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer.
International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.
Summers et al., Berlin, Germany. In Pharmacol Rev, 2014
RXFP1 activates pleiotropic signaling pathways including the signalosome protein complex that facilitates high-sensitivity signaling; coupling to Gα(s), Gα(i), and Gα(o) proteins; interaction with glucocorticoid receptors; and the formation of hetero-oligomers with distinctive pharmacological properties.
In a Class of Their Own - RXFP1 and RXFP2 are Unique Members of the LGR Family.
Gooley et al., Melbourne, Australia. In Front Endocrinol (lausanne), 2014
The leucine-rich repeat-containing G protein-coupled receptors (LGRs) family consists of three groups: types A, B, and C and all contain a large extracellular domain (ECD) made up of the structural motif - the leucine-rich repeat (LRR).
Regulation of the reproductive cycle and early pregnancy by relaxin family peptides.
Ivell et al., Germany. In Mol Cell Endocrinol, 2014
Relaxin exerts its functions via the receptor RXFP1.
Relaxin family peptides and their receptors.
Summers et al., Australia. In Physiol Rev, 2013
Although they are structurally related to insulin, the relaxin family peptides produce their physiological effects by activating a group of four G protein-coupled receptors (GPCRs), relaxin family peptide receptors 1-4 (RXFP1-4).
Male factor infertility: a relaxin effect on sperm parameters.
Fenner, In Nat Rev Urol, 2011
[review] The relaxin receptor RXFP1 localizes in the acrosomal region of sperm.
Endometrial LGR7 expression during menstrual cycle.
Colacurci et al., Napoli, Italy. In Fertil Steril, 2011
LGR7 is constitutively expressed in human endometrium, and an increased LGR7 immunostaining is demonstrated in the secretory phase, confirming the involvement of relaxin in the physiology of endometrium and suggesting its role in implantation.
H3 relaxin demonstrates antifibrotic properties via the RXFP1 receptor.
Samuel et al., Melbourne, Australia. In Biochemistry, 2011
H3 relaxin exerts antifibrotic actions via RXFP1 receptor
Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis.
Agoulnik et al., Houston, United States. In Endocr Relat Cancer, 2010
The downregulation of RXFP1 resulted in significant decrease in metastasis rate in PC3 tumors.
Decreased expression of the rat myometrial relaxin receptor (RXFP1) in late pregnancy is partially mediated by the presence of the conceptus.
Parry et al., Melbourne, Australia. In Biol Reprod, 2010
investigation of expression of RXFP1 in uterine tissues before, during, and after pregnancy; fetal-placental unit appears involved in regulation of expression of RXFP1; down-regulation of RXFP1 expression occurs in late gestation
International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides.
Summers et al., Melbourne, Australia. In Pharmacol Rev, 2006
In this review it is suggested that the receptors for relaxin (LGR7) and those for the related peptides insulin-like peptide 3 (LGR8), relaxin-3 (GPCR135), and insulin-like peptide 5 (LGPCR142) be named the relaxin family peptide receptors 1 through 4 (RXFP1-4).
Activation of orphan receptors by the hormone relaxin.
Hsueh et al., Stanford, United States. In Science, 2002
capable of mediating the action of relaxin through an adenosine 3',5'-monophosphate (cAMP)-dependent pathway
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