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Fas apoptotic inhibitory molecule 2

LFG, neural membrane protein 35, FAIM2, NMP35
may mediate development and maintenance of the nervous system [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: FTO, MC4R, fibrillin-1, Brain-derived neurotrophic factor, AGE
Papers on LFG
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
Bone Mineral Density in Childhood Study BMDCS et al., Copenhagen, Denmark. In Hum Mol Genet, Feb 2016
In total, 15 loci reached genome-wide significance (P-value < 5 × 10(-8)) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or childhood obesity.
Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells.
Comella et al., Barcelona, Spain. In J Biol Chem, Feb 2016
Lifeguard (LFG) is a death receptor antagonist mainly expressed in the nervous system that specifically blocks Fas ligand (FasL)-induced apoptosis.
Characterization of H2S removal and microbial community in landfill cover soils.
He et al., Hangzhou, China. In Environ Sci Pollut Res Int, Dec 2015
With the input of landfill gas (LFG), the gas concentrations of CH4, CO2, O2, and H2S, microbial community and activity in landfill covers changed with time.
TRIM21, a negative modulator of LFG in breast carcinoma MDA-MB-231 cells in vitro.
Bucan et al., Hannover, Germany. In Int J Oncol, Nov 2015
Lifeguard (LFG) is a transmembrane protein which is highly expressed in tissues of the hippocampus and the cerebellum, especially during postnatal development.
Promoter methylation of fas apoptotic inhibitory molecule 2 gene is associated with obesity and dyslipidaemia in Chinese children.
Mi et al., Beijing, China. In Diab Vasc Dis Res, May 2015
Fas apoptotic inhibitory molecule 2 (FAIM2) is an obesity-related gene, but the mechanisms by which FAIM2 is involved in obesity are not understood.
Targeting the cyclin-binding groove site to inhibit the catalytic activity of CDK2/cyclin A complex using p27(KIP1)-derived peptidomimetic inhibitors.
Singh et al., Kāraikkudi, India. In J Chem Biol, 2015
Greater understanding of the interaction of CDK2/cyclin A complex with p27 (negative regulator) reveals that the Leu-Phe-Gly (LFG) motif region of p27 binds with the CBG site of cyclin A to arrest the malignant cell proliferation that induces apoptosis.
Antiapoptotic Role for Lifeguard in T Cell Mediated Immune Response.
Verma et al., Los Angeles, United States. In Plos One, 2014
Anti-apoptotic protein Lifeguard (LFG) is upregulated on T cells upon in vitro activation.
Characterizing gene-gene interactions in a statistical epistasis network of twelve candidate genes for obesity.
Gilbert-Diamond et al., United States. In Biodata Min, 2014
In this study, we aimed to analyze pairwise interactions that are associated with Body Mass Index (BMI) between SNPs from twelve genes robustly associated with obesity (BDNF, ETV5, FAIM2, FTO, GNPDA2, KCTD15, MC4R, MTCH2, NEGR1, SEC16B, SH2B1, and TMEM18).
KRT13, FAIM2 and CYP2W1 mRNA expression in oral squamous cell carcinoma patients with risk habits.
Zain et al., Kuala Lumpur, Malaysia. In Asian Pac J Cancer Prev, 2014
BACKGROUND: Expression of KRT13, FAIM2 and CYP2W1 appears to be influenced by risk habits, thus exploring the associations of these genes in oral squamous cell cancer (OSCC) with risk habits, clinico-pathological parameters and patient survival may be beneficial in identifying relevant biomarkers with different oncogenic pathways.
Influence of lifestyle on the FAIM2 promoter methylation between obese and lean children: a cohort study.
Mi et al., Beijing, China. In Bmj Open, 2014
OBJECTIVE: An obesity-related gene, Fas apoptotic inhibitory molecule 2 (FAIM2), is regulated by nutritional state and the methylation levels of the FAIM2 promoter are significantly associated with obesity.
Obesity gene NEGR1 associated with white matter integrity in healthy young adults.
Thompson et al., Los Angeles, United States. In Neuroimage, 2014
Here we aim to see whether variants in obesity-associated genes--NEGR1, FTO, MTCH2, MC4R, LRRN6C, MAP2K5, FAIM2, SEC16B, ETV5, BDNF-AS, ATXN2L, ATP2A1, KCTD15, and TNN13K--are associated with white matter microstructural properties, assessed by high angular resolution diffusion imaging (HARDI) in young healthy adults between 20 and 30 years of age from the Queensland Twin Imaging study (QTIM).
[Impact of obesity-related gene polymorphism on risk of obesity and metabolic disorder in childhood].
Mi et al., Beijing, China. In Zhonghua Yu Fang Yi Xue Za Zhi, 2014
A total of 11 single nucleotide polymorphisms were genotyped by TaqMan allelic discrimination assays with the GeneAmp 7900 sequence detection system (Applied Biosystems, Foster City, CA, USA) (FTO rs9939609, MC4R rs17782313, GNPDA2 rs10938397, FAIM2 rs7138803, BDNF rs6265, NPC1 rs1805081, PCSK1 rs6235, KCTD15 rs29941, BAT2 rs2844479, SEC16B rs10913469 and SH2B1 rs4788102).
MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness.
Comella et al., Barcelona, Spain. In Cell Death Dis, 2013
We report that Lifeguard (LFG/FAIM2 (Fas apoptosis inhibitory molecule 2)/NMP35) is downregulated in the most aggressive and undifferentiated tumors.
What model organisms and interactomics can reveal about the genetics of human obesity.
Schiöth et al., Uppsala, Sweden. In Cell Mol Life Sci, 2012
Here, we searched biological databases and discovered 33 additional genes associated with human obesity (CADM2, GIPR, GPCR5B, LRP1B, NEGR1, NRXN3, SH2B1, FANCL, GNPDA2, HMGCR, MAP2K5, NUDT3, PRKD1, QPCTL, TNNI3K, MTCH2, DNAJC27, SLC39A8, MTIF3, RPL27A, SEC16B, ETV5, HMGA1, TFAP2B, TUB, ZNF608, FAIM2, KCTD15, LINGO2, POC5, PTBP2, TMEM18, TMEM160).
Antiapoptotic protein Lifeguard is required for survival and maintenance of Purkinje and granular cells.
Verma et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2011
mechanism of action of LFG as an inhibitor of the Fas pathway and evidence of the neuroprotective role of LFG in cerebellar granule neurons and Purkinje cells in an organotypic cerebellar culture system
Fas/CD95 regulatory protein Faim2 is neuroprotective after transient brain ischemia.
Schulz et al., Aachen, Germany. In J Neurosci, 2011
This study demonistrated that lack of Faim2 caused an increase in susceptibility to combined oxygen-glucose deprivation in primary neurons as well as in caspase-associated cell death, stroke volume, and neurological impairment after cerebral ischemia.
Genome-wide population-based association study of extremely overweight young adults--the GOYA study.
Sørensen et al., Bristol, United Kingdom. In Plos One, 2010
Analysis identified SNPs at three loci known to be associated with BMI with genome-wide confidence (P<5x10(-8); FTO, MC4R and FAIM2).
The anti-apoptotic protein lifeguard is expressed in breast cancer cells and tissues.
Vogt et al., Hannover, Germany. In Cell Mol Biol Lett, 2010
LFG is strongly expressed in breast cancer epithelial cells. Moreover, the overexpression of LFG correlated with tumour grade and reduced Fas sensitivity.
Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.
Nakamura et al., Yokohama, Japan. In J Hum Genet, 2009
Data show that SNPs in SEC16B and TMEM18 were significantly associated with obesity, and the SNPs in GNPDA2, BDNF, FAIM2 and MC4R were marginally associated with obesity in Japanese.
The Bax Inhibitor-1 (BI-1) family in apoptosis and tumorigenesis.
Vogt et al., Hannover, Germany. In Curr Mol Med, 2008
Although most members of this family are still not characterized an antiapoptotic effect has been described for BI-1, Lifeguard (LFG), and the Golgi anti-apoptotic protein (GAAP).
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