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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Leukotriene B4 receptor

leukotriene B4 receptor, BLT1, BLT
may mediate macrophage recruitment and activation [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, V1a, CAN, HAD, 5-lipoxygenase
Papers on leukotriene B4 receptor
Leukotriene B4 receptor-2 contributes to chemoresistance of SK-OV-3 ovarian cancer cells through activation of signal transducer and activator of transcription-3-linked cascade.
Kim et al., Seoul, South Korea. In Biochim Biophys Acta, Feb 2016
In this study, we found that the low-affinity leukotriene B4 receptor-2 (BLT2) and its ligand leukotriene B4 were highly up-regulated in cisplatin-resistant SK-OV-3 ovarian cancer cells and play critical roles in mediating the chemoresistance through the activation of signal transducer and activator of transcription-3 (STAT-3) and the subsequent up-regulation of interleukin-6 (IL-6).
Dual Role of 5-Lipoxygenase in Osteoclastogenesis in Bacterial-induced Apical Periodontitis.
Faccioli et al., Ribeir√£o Preto, Brazil. In J Endod, Feb 2016
RESULTS: Root canal contamination induced the expression of messenger RNA for 5-LO and leukotriene B4 receptors BLT1 and BLT2.
Anticancer activity of bicalutamide-loaded PLGA nanoparticles in prostate cancers.
Yang et al., China. In Exp Ther Med, Dec 2015
Bicalutamide (BLT) is an antineoplastic hormonal agent primarily used in the treatment of locally advanced and metastatic prostate cancers.
Cigarette smoke-induced lung inflammation in COPD mediated via LTB4/BLT1/SOCS1 pathway.
He et al., Shanghai, China. In Int J Chron Obstruct Pulmon Dis, Dec 2015
We investigated the relationship between smoking, SOCS1, and leukotriene B4 (LTB4) in vitro and in clinical samples of COPD; besides which we detected the impact of LTB4 receptor 1 (BLT1) antagonist on inflammation.
Differential Contribution of BLT1 and BLT2 to Leukotriene B4-Induced Human NK Cell Cytotoxicity and Migration.
Stankova et al., Sherbrooke, Canada. In Mediators Inflamm, 2014
The use of selective BLTR antagonists indicated that BLT1 was involved in both LTB4-induced migration and cytotoxicity, whereas BLT2 was involved exclusively in NK cell migration, but only in response to higher concentrations of LTB4.
Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7.
Rovati et al., Stockholm, Sweden. In Br J Pharmacol, 2014
The LT receptors BLT1 and BLT2 , are activated by LTB4 and the CysLT1 and CysLT2 receptors are activated by the cysteinyl-LTs, whereas oxoeicosanoids exert their action through the OXE receptor.
Humanized Mice for Studying Human Immune Responses and Generating Human Monoclonal Antibodies.
Akkina, In Microbiol Spectr, 2014
The Hu-HSC model uses the transplantation of human hematopoietic stem cells (HSCs), whereas the BLT mouse model is created by transplantation of human fetal liver, thymus, and HSC.
A review on leukotrienes and their receptors with reference to asthma.
Ray et al., Gurgaon, India. In J Asthma, 2013
RESULTS: CysLTs including LTC4, LTD4 and LTE4 are ligands for CysLT1 and CysLT2 receptors, and LTB4 is the agonist for BLT1 and BLT2 receptors.
Natural resolution of inflammation.
Van Dyke et al., In Periodontol 2000, 2013
G protein-coupled receptor 32, lipoxin A4 receptor/formyl peptide receptor2, chemokine-like receptor 1, leukotriene B4 receptor type 1 and cabannoid receptor 2) induces cessation of leukocyte infiltration; vascular permeability/edema returns to normal with polymorphonuclear neutrophil death (mostly via apoptosis), the nonphlogistic infiltration of monocyte/macrophages and the removal (by macrophages) of apoptotic polymorphonuclear neutrophils, foreign agents (bacteria) and necrotic debris from the site.
Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation.
Geha et al., Boston, United States. In Immunity, 2012
In mice, this influx was largely dependent on the generation of leukotriene B4 (LTB4) by neutrophils and their expression of the LTB4 receptor BLT1.
Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.
Peters-Golden et al., Ann Arbor, United States. In J Immunol, 2012
Signaling through its high-affinity G protein-coupled receptor leukotriene B4 receptor 1 (BLT1) directs dectin-1-dependent binding, ingestion, and cytokine production both in vitro and in vivo.
A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake - Probe 3
Schreiber et al., Bethesda, United States. In Unknown Journal, 2012
As a tool compound, ML312 is distinct from prior small-molecule inhibitors of SR-BI (e.g., BLT-1 and ITX-5061), and it has better solubility than the existing probes identified concurrently in this project, ML278 and ML279.
Leukotriene B(4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products.
Shin et al., Seoul, South Korea. In Inflamm Res, 2012
The results suggested that LTB4 receptors BLT1 and BLT2 are involved in IL-8 production in and secretion by human neutrophils induced by T. vaginalis.
International Union of Basic and Clinical Pharmacology. LXXXIV: leukotriene receptor nomenclature, distribution, and pathophysiological functions.
Rovati et al., Stockholm, Sweden. In Pharmacol Rev, 2011
These receptors have been designated BLT and CysLT receptors, respectively, and a subdivision into BLT(1) and BLT(2) receptors and CysLT(1) and CysLT(2) receptors has been established.
Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity.
Haribabu et al., Louisville, United States. In J Immunol, 2011
a novel role of chemoattractant receptor, BLT-1, in promoting monocyte trafficking to adipose tissue and promoting chronic inflammation in obesity
Leukotriene receptors are differently expressed in fibroblast from peripheral versus central airways in asthmatics and healthy controls.
Bjermer et al., Lund, Sweden. In Prostaglandins Leukot Essent Fatty Acids, 2011
leukotriene B(4) receptors (BLT(1) and BLT(2)) are differently expressed in fibroblast from peripheral versus central airways in asthmatics and healthy controls.
The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers.
Sayers et al., Nottingham, United Kingdom. In Bmc Med Genet, 2010
The polymorphisms spanning LTB4R is not major determinants of baseline lung function in smokers.
Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis.
Luster et al., Boston, United States. In Immunity, 2010
We previously demonstrated an absolute requirement for the lipid chemoattractant leukotriene B(4) (LTB(4)) and its receptor BLT1 for neutrophil recruitment into the joint in autoantibody-induced arthritis.
Prospects for new drugs for chronic obstructive pulmonary disease.
Hansel et al., London, United Kingdom. In Lancet, 2004
More specific approaches are to give antioxidants, inhibitors of inducible nitric oxide synthase, and antagonists of leukotriene B4 receptor.
Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues.
von Andrian et al., Boston, United States. In Nat Immunol, 2003
Results identify LTB4-BLT1 as a potent nonchemokine pathway for cytotoxic effector cell traffic.
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