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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Elastase, neutrophil expressed

Leukocyte Elastase, neutrophil elastase, HNE, HLE
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009] (from NCBI)
Top mentioned proteins: elastase, CAN, HAD, V1a, ACID
Papers using Leukocyte Elastase antibodies
The effects on Trypanosoma cruzi of novel synthetic naphthoquinones are mediated by mitochondrial dysfunction.
Rénia Laurent, In PLoS ONE, 2008
... Mouse monoclonal anti-4-hydroxy-2-nonenal (4-HNE) antibody was from Abcam Inc ...
Inflammatory bowel disease: past, present, and future
Kim Dong-Hyun et al., In Journal of Inflammation (London, England), 2006
... 4-HNE was purchased from Cayman Chemical Co ...
Plasmodium falciparum-infected erythrocytes decrease the integrity of human blood-brain barrier endothelial cell monolayers
Arese Paolo et al., In Malaria Journal, 2006
... 4-hydroxynonenal (HNE) was from Biomol, Plymouth Meeting, PA ...
Acetaldehyde-mediated neurotoxicity: relevance to fetal alcohol spectrum disorders
Moskal Peter et al., In Molecular Brain, 2002
... (NGF), neurotrophin 3 (NT3), neurotrophin 4 (NT4), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), choline acetyltransferase (ChAT), acetylcholinesterase (AChE), and 4-hydroxy-2-nonenal (HNE) were purchased from Abcam Inc ...
Global Analysis of Protein Damage by the Lipid Electrophile 4-Hydroxy-2-nonenal*S⃞
Liebler Daniel C. et al., In Molecular & Cellular Proteomics : MCP, 2001
... HNE was obtained from Cayman Chemical (Ann Arbor, MI) ...
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Papers on Leukocyte Elastase
Carrageenan-induced inflammation promotes ROS generation and neutrophil extracellular trap formation in a mouse model of peritonitis.
Donadio et al., Porto Alegre, Brazil. In Eur J Immunol, Feb 2016
UNASSIGNED: Neutrophil extracellular traps (NETs) are a combination of DNA fibers and granular proteins, such as neutrophil elastase (NE).
COPD is characterized by increased detection of Haemophilus influenzae, Streptococcus pneumoniae and a deficiency of Bacillus species.
Hansbro et al., Newcastle, Australia. In Respirology, Feb 2016
Supernatants were assessed for neutrophil elastase (NE) and IL-1β.
Protocatechualdehyde Protects Against Cerebral Ischemia-Reperfusion-Induced Oxidative Injury Via Protein Kinase Cε/Nrf2/HO-1 Pathway.
Wen et al., Xi'an, China. In Mol Neurobiol, Feb 2016
Treatment with PCA significantly improved neurologic score, reduced infarct volume and necrotic neurons, and also decreased reactive oxygen species (ROS) production, 4-hydroxynonenal (4-HNE), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) contents at 24 h after reperfusion.
Long-term azithromycin ameliorates not only airway inflammation but also remodeling in a murine model of chronic asthma.
Kim et al., Seoul, South Korea. In Pulm Pharmacol Ther, Feb 2016
The levels of neutrophil elastase, Interleukin (IL)-8, and BRP-39 (human homologue YKL-40) were assessed.
Human neutrophil elastase inhibition studied by capillary electrophoresis with laser induced fluorescence detection (LIF) and microscale thermophoresis (MST).
Morin et al., Orléans, France. In J Chromatogr A, Feb 2016
UNASSIGNED: Capillary electrophoresis-laser induced fluorescence (CZE-LIF) and microscale thermophoresis (MST) were used for the first time to study the inhibition of human neutrophil elastase (HNE).
Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease.
Sorsa et al., Helsinki, Finland. In Innate Immun, Jan 2016
MMP-8, MMP-9 and neutrophil elastase).
Secretory leukocyte protease inhibitor (SLPI), a multifunctional protein in the host defense response.
Cichy et al., Kraków, Poland. In Cytokine Growth Factor Rev, Jan 2016
First described as an inhibitor of serine proteases such as neutrophil elastase, this protein is increasingly recognized as a molecule that benefits the host via its anti-proteolytic, anti-microbial and immunomodulatory activities.
Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling.
Awasthi et al., Duarte, United States. In Toxicol Appl Pharmacol, Jan 2016
Cells exposed to mild, transient heat or oxidative stress acquire the capacity to exclude intracellular 4HNE at a faster rate by inducing GSTA4-4 which conjugates 4HNE to glutathione (GSH), and RLIP76 which mediates the ATP-dependent transport of the GSH-conjugate of 4HNE (GS-HNE).
Therapeutic Potential to Modify the Mucus Barrier in Inflammatory Bowel Disease.
Li et al., Nanjing, China. In Nutrients, Dec 2015
We also review the involvement of the mucus barrier in the exacerbation of the disease and explore the therapeutic potential of modifying the mucus barrier with short-chain fatty acids, prebiotics, probiotics, fatty acid synthase, H₂S, neutrophil elastase inhibitor and phophatidyl choline.
Evolution of cystic fibrosis lung function in the early years.
Sly et al., Brisbane, Australia. In Curr Opin Pulm Med, Nov 2015
AREST-CF also reported a high prevalence of high resolution computed tomographic abnormalities related to free neutrophil elastase in bronchoalveolar lavage; LCFC reported high resolution computed tomographic changes at 1 year, which were too mild to be scored reproducibly.
Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo.
Nourshargh et al., Genève, Switzerland. In Immunity, Jul 2015
Local proteolytic cleavage of EC JAM-C by neutrophil elastase (NE) drove this cascade of events as supported by presentation of NE to JAM-C via the neutrophil adhesion molecule Mac-1.
The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
Kuner et al., Heidelberg, Germany. In Nat Med, May 2015
T lymphocytes infiltrate the DRG after nerve injury and release leukocyte elastase (LE), which was inhibited by SerpinA3N derived from DRG neurons.
Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens.
Papayannopoulos et al., London, United Kingdom. In Nat Immunol, 2014
Phagocytosis via dectin-1 acted as a sensor of microbe size and prevented NET release by downregulating the translocation of neutrophil elastase (NE) to the nucleus.
A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles.
Cravatt et al., Los Angeles, United States. In Nat Methods, 2014
Using this approach, we identified a select set of proteins that constitute 'hot spots' for modification by various lipid-derived electrophiles, including the oxidative stress product 4-hydroxy-2-nonenal (HNE).
Risk factors for bronchiectasis in children with cystic fibrosis.
AREST CF Investigators et al., Brisbane, Australia. In N Engl J Med, 2013
In multivariate analyses, risk factors for bronchiectasis were presentation with meconium ileus (odds ratio, 3.17; 95% confidence interval [CI], 1.51 to 6.66; P=0.002), respiratory symptoms at the time of CT and BAL (odds ratio, 2.27; 95% CI, 1.24 to 4.14; P=0.008), free neutrophil elastase activity in BAL fluid (odds ratio, 3.02; 95% CI, 1.70 to 5.35; P<0.001), and gas trapping on expiratory CT (odds ratio, 2.05; 95% CI, 1.17 to 3.59; P=0.01).
Neonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growth.
Bland et al., Stanford, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
High elastase expression is associated with defective alveolar septation and arrested lung growth.
Mutations in the ELANE gene are associated with development of periodontitis in patients with severe congenital neutropenia.
Pütsep et al., Huddinge, Sweden. In J Clin Immunol, 2011
ELANE genetic polymorphism is associated with development of periodontitis in patients with severe congenital neutropenia
Alveolar fractal box dimension inversely correlates with mean linear intercept in mice with elastase-induced emphysema.
Dhand et al., United States. In Int J Chron Obstruct Pulmon Dis, 2011
Report on development of pulmonary emphysema after intratracheal instillation of human neutrophil elastase.
Exploring Tagetes erecta Linn flower for the elastase, hyaluronidase and MMP-1 inhibitory activity.
Mukherjee et al., Calcutta, India. In J Ethnopharmacol, 2011
Tagetes erecta flower showed effective inhibition of leukocyte elastase.
Neutrophil elastase enhances sputum solubilization in cystic fibrosis patients receiving DNase therapy.
Zychlinsky et al., Berlin, Germany. In Plos One, 2010
In a process reminiscent of neutrophil extracellular traps formation, NE enhances sputum solubilization.
More papers using Leukocyte Elastase antibodies
Colonic cell proliferation and agerrant crypt foci formation are inhibited by dairy glycosphingolipids in 1,2-dimethylhydrazine-treated CF1 mice
Fujimoto Yohko et al., In Journal of Clinical Biochemistry and Nutrition, 1999
... 4-Hydroxynonenal (4-HNE), 4-hydroxyhexenal (4-HHE) and 4-ONE were purchased from Cayman Chemical Co ...
Assay method for myeloperoxidase in human polymorphonuclear leukocytes
Hojo Hiroshi et al., In Oxidative Medicine and Cellular Longevity, 1982
... HNE was from Cayman Chemical Co ...
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