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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Leucine aminopeptidase 3

leucine aminopeptidase, L-AP3
Top mentioned proteins: aminopeptidase, ACID, LAP, HAD, CAN
Papers on leucine aminopeptidase
Inhibition of leucine aminopeptidase 3 suppresses invasion of ovarian cancer cells through down-regulation of fascin and MMP-2/9.
Fang et al., Weifang, China. In Eur J Pharmacol, Jan 2016
Leucine aminopeptidase 3 (LAP3) is a cell surface aminopeptidase that catalyzes the hydrolysis of leucine residues from the amino termini of protein or peptide substrates.
Harmful effects of silver nanoparticles on a complex detrital model system.
Gessner et al., Dübendorf, Switzerland. In Nanotoxicology, Jan 2016
Both AgNP and Ag(+) also stimulated extracellular alkaline phosphatase but reduced leucine aminopeptidase, whereas β-glucosidase was stimulated by AgNP and reduced by Ag(+).
BML-111 Attenuates Renal Ischemia/Reperfusion Injury Via Peroxisome Proliferator-Activated Receptor-α-Regulated Heme Oxygenase-1.
Wang et al., Nanjing, China. In Inflammation, Dec 2015
BML-111 treatment resulted in a marked reduction in the severity of histological features of renal I/R injury, and attenuated the rise in renal myeloperoxidase and malondialdehyde, blood urea nitrogen and creatinine, urinary N-acetyl-β-glucosaminidase, and leucine aminopeptidase levels caused by I/R injury.
Using cornstarch in microparticulate diets for larvicultured tropical gar (Atractosteus tropicus).
Martínez-García et al., Villahermosa, Mexico. In Fish Physiol Biochem, Dec 2015
Major digestive enzyme activities occurred (acid protease, alkaline protease, trypsin, chymotrypsin, leucine aminopeptidase, carboxypeptidase A, lipase, α-glucosidase and amylase) for larvae fed D3.
A suggested guiding panel of seromarkers for efficient discrimination between primary and secondary human hepatocarcinoma.
Gerges et al., Egypt. In Tumour Biol, Oct 2015
Carcinoembryonic antigen (CEA), total glycosaminoglycans (TGAGs), total sialic acid (TSA), free glucosamine (FGA), leucine aminopeptidase (LAP), 5'-nucleotidase (5'-NU) activities, and AFP were estimated in sera, in addition to liver histology.
New insights into the role of sex steroid hormones in pregnancy: possible therapeutic approach by sex steroid hormones for the treatment of both preeclampsia and preterm labor.
Mizutani et al., Nagoya, Japan. In Exp Clin Endocrinol Diabetes, Mar 2015
Since these hormones are biologically active, the leakage of these hormones into the maternal circulation is regulated by degradation activity by placental aminopeptidases, in order to maintain the balance between carriage of pregnancy and onset of labor.Because the concentration of these hormones, being regulated by the amount of endogenous production and by physiological degradation by enzymes in the blood and tissue, the balance between production and degradation is a definitive element for maintaining normal gestation and term delivery.The changes of the balance between fetal angiotensin II (A-II) and vasopressin (AVP) andA-II and AVP degrading enzymes, between aminopeptidase A (APA) and placental leucine aminopeptidase( P-LAP) - in the placenta and maternal blood due to fetal stress such as hypoxia - are the provable causes of preeclampsia or preterm labor.Induction of APA and P-LAP by estradiol benzoate (E2) and progesterone (P) from placenta has been demonstrated.
Theoretical insights into the functioning of metallopeptidases and their synthetic analogues.
Prabhakar et al., Coral Gables, United States. In Acc Chem Res, Mar 2015
In particular, the role of the metal ions, ligands, and microenvironment in the functioning of mono- and binuclear metal center containing enzymes such as insulin degrading enzyme (IDE) and bovine lens leucine aminopeptidase (BILAP), respectively, and their synthetic analogues have been investigated.
Positioning of aminopeptidase inhibitors in next generation cancer therapy.
Peters et al., Amsterdam, Netherlands. In Amino Acids, 2014
This review focuses on the function and subcellular location of five key aminopeptidases (aminopeptidase N, leucine aminopeptidase, puromycin-sensitive aminopeptidase, leukotriene A4 hydrolase and endoplasmic reticulum aminopeptidase 1/2) and their association with different diseases, in particular cancer and their current position as target for therapeutic intervention by aminopeptidase inhibitors.
Inhibitors of the Plasmodium falciparum M17 Leucine Aminopeptidase
Dalton et al., Bethesda, United States. In Unknown Journal, 2014
For survival, the Plasmodium falciparum (Pf) malaria parasite requires the action of a number of metallo-aminopeptidases, including PfM1MAA (membrane alanine aminopeptidase), PfM17LAP (leucine aminopeptidase), and PfM18AAP (aspartyl aminopeptidase).
Effects of a lipid-encapsulated zinc oxide supplement on growth performance and intestinal morphology and digestive enzyme activities in weanling pigs.
Lee et al., Chinju, South Korea. In J Anim Sci Technol, 2013
Specific activities of sucrase, maltase, and leucine aminopeptidase in these intestinal regions and those of amylase and trypsin in the pancreas were not influenced by the lipid content or dietary concentration of LE ZnO and also did not differ between the LE-ALL and either of the BASAL and HIGH groups, except for a greater pancreatic amylase activity in the former vs. HIGH group.
Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase
Gardiner et al., Bethesda, United States. In Unknown Journal, 2013
For survival, the Plasmodium falciparum (Pf) malaria parasite requires the action of a number of metallo-aminopeptidases that each display restricted amino acid specificities, including PfM1MAA (membrane alanine aminopeptidase), PfM17LAP (leucine aminopeptidase), and PfM18AAP (aspartyl aminopeptidase), which are thought to act in concert to degrade host erythrocyte hemoglobin that the parasite uses as a source of amino acid building blocks for the synthesis of its own proteins.
The Reaction Mechanism of Bovine Lens Leucine Aminopeptidase.
Clark et al., Burgess Hill, United Kingdom. In J Phys Chem B, 2002
We present a quantum mechanical/molecular mechanical (QM/MM) study using the AM1 Hamiltonian and a flexible MM part on the mode of action of the bovine lens leucine aminopeptidase (blLAP), a cytosolic exopeptidase that catalyzes the cleavage of the N-terminal amide bond of peptides.
Alkaline phosphatase and leucine aminopeptidase association in plasma of the chicken.
Law, In Science, 1967
Two electrophoretic vari ants of leucine aminopeptidase show direct association with two genetically controlled forms of alkaline phosphatase.
Angiotensinase with a high degree of specificity in plasma and red cells.
SMEBY et al., In Science, 1963
This enzyme, given the name angiotensinase A, requires alpha-L-aspartic acid or alpha-L-asparagine as the N-terminal amino acid in its angiotensin substrate, and thus differs from kidney leucine aminopeptidase.
Subfractionation of human serum enzymes.
HILBURN et al., In Science, 1960
These subfractions and unfractionated leucine aminopeptidase are localized with respect to the protein zones of the Smithies starch gel pattern.
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