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Leucine zipper-EF-hand containing transmembrane protein 1

This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: WHS, CAN, V1a, HAD, fibrillin-1
Papers on LETM1
Systematic analysis of copy number variants of a large cohort of orofacial cleft patients identifies candidate genes for orofacial clefts.
Zhou et al., Nijmegen, Netherlands. In Hum Genet, Jan 2016
Our analyses of these overlapping CNVs identified two genes known to be causative for human OFCs, SATB2 and MEIS2, and 12 genes (DGCR6, FGF2, FRZB, LETM1, MAPK3, SPRY1, THBS1, TSHZ1, TTC28, TULP4, WHSC1, WHSC2) that are associated with OFC or orofacial development.
Important mitochondrial proteins in human omental adipose tissue show reduced expression in obesity.
Walker et al., Basel, Switzerland. In Data Brief, Sep 2015
Further quantification of 12 of these 62 proteins by immune dot blot analysis revealed four proteins citrate synthase, HADHA, LETM1 and mitofilin being inversely associated with BMI, and mitofilin being inversely correlated with gender.
Effects of JIP3 on epileptic seizures: Evidence from temporal lobe epilepsy patients, kainic-induced acute seizures and pentylenetetrazole-induced kindled seizures.
Wang et al., Chongqing, China. In Neuroscience, Sep 2015
We found that JIP3 was markedly increased in TLE patients and a mouse model of epileptic seizures; mice underexpressing JIP3 through lentivirus bearing LV-Letm1-RNAi showed decreased susceptibility, delayed first seizure and decreased seizure duration response to the epileptogenic properties of KA.
Important mitochondrial proteins in human omental adipose tissue show reduced expression in obesity.
Walker et al., Basel, Switzerland. In J Proteomics, Jul 2015
The immunological quantification of 12 mitochondrial proteins from 76 omental adipose tissue biopsies revealed four proteins, citrate synthase, HADHA, LETM1 and mitofilin inversely being associated with BMI, and mitofilin being inversely correlated with gender.
The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice.
Kochanek et al., Pittsburgh, United States. In J Cereb Blood Flow Metab, Apr 2015
Finally, we confirm that RBM5/10 regulate protein expression of several target genes including caspase-2, cellular FLICE-like inhibitory protein (c-FLIP), LETM1 Domain-Containing Protein 1 (LETMD1), and amyloid precursor-like protein 2 (APLP2) in neuronal cells.
Clinical implication of leucine zipper/EF hand-containing transmembrane-1 overexpression in the prognosis of triple-negative breast cancer.
Piao et al., Changchun, China. In Exp Mol Pathol, Apr 2015
The leucine zipper/EF hand-containing transmembrane-1 (LETM1) protein, which is a mitochondrial inner membrane protein, can reduce mitochondrial biogenesis and ATP production.
The destiny of Ca(2+) released by mitochondria.
Matsuoka et al., Fukui, Japan. In J Physiol Sci, 2015
In the last 5 years, the molecules responsible for mitochondrial Ca(2+) dynamics have been identified: a mitochondrial Ca(2+) uniporter (MCU), a mitochondrial Na(+)-Ca(2+) exchanger (NCLX), and a candidate for a mitochondrial H(+)-Ca(2+) exchanger (Letm1).
LETM1 overexpression is correlated with the clinical features and survival outcome of breast cancer.
Liu et al., Yanji, China. In Int J Clin Exp Pathol, 2014
BACKGROUND: Leucine zipper/EF hand-containing transmembrane-1 (LETM1) is a mitochondrial inner membrane protein that was first identified in Wolf-Hirschhorn syndrome.
The Shepherds' Tale: A Genome-Wide Study across 9 Dog Breeds Implicates Two Loci in the Regulation of Fructosamine Serum Concentration in Belgian Shepherds.
Höglund et al., Uppsala, Sweden. In Plos One, 2014
The associated region and its close neighbourhood harbours interesting candidate genes such as LETM1 and GAPDH that are important in glucose metabolism and have previously been implicated in the aetiology of diabetes mellitus.
Reliance of ER-mitochondrial calcium signaling on mitochondrial EF-hand Ca2+ binding proteins: Miros, MICUs, LETM1 and solute carriers.
Weaver et al., Philadelphia, United States. In Curr Opin Cell Biol, 2014
A common Ca(2+) sensing mechanism is the EF-hand Ca(2+) binding domain, many of which can be found in proteins of the mitochondria, including Miro1&2, MICU1,2&3, LETM1 and mitochondrial solute carriers.
[H+-Ca2+-exchanger in the myometrium mitochondria: modulation of exogenous and endogenous compounds].
Danylovych et al., In Fiziol Zh, 2013
This process is insensitive to the tetraphenylphosphonium which is relatively specific Na+-Ca2+-exchanger inhibitor of mitochondrial inner membrane, but inhibited in the presence of monoclonal antibodies directed against the protein LETM1 (Anti-LETM1).
Calcium transport across the inner mitochondrial membrane: molecular mechanisms and pharmacology.
Hajnóczky et al., Philadelphia, United States. In Mol Cell Endocrinol, 2012
Recent RNA interference studies have identified new candidate proteins for Ca(2+) transport across the inner mitochondrial membrane, including LETM1, MCU, MICU1 and NCLX.
A novel 4p16.3 microduplication distal to WHSC1 and WHSC2 characterized by oligonucleotide array with new phenotypic features.
Shchelochkov et al., Iowa City, United States. In Am J Med Genet A, 2011
we have identified a novel submicroscopic duplication involving dosage sensitive genes TACC3, FGFR3, and LETM1.
Leucine zipper EF hand-containing transmembrane protein 1 (Letm1) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways.
Graier et al., Graz, Austria. In J Biol Chem, 2011
Letm1 and UCP2/3 independently contribute to two distinct, mitochondrial Ca(2+) uptake pathways in intact endothelial cells.
Distinctive characteristics and functions of multiple mitochondrial Ca2+ influx mechanisms.
Sheu et al., Philadelphia, United States. In Sci China Life Sci, 2011
These are mitochondrial ryanodine receptor, mitochondrial uncoupling proteins, LETM1 (Ca(2+)/H(+) exchanger), and MCU and its Ca(2+) sensing regulatory subunit MICU1.
Calcium uptake mechanisms of mitochondria.
Demaurex et al., Genève, Switzerland. In Biochim Biophys Acta, 2010
Recently, leucine-zipper-EF hand-containing transmembrane region (Letm1) was proposed to be an electrogenic 1:1 mitochondrial Ca2+/H+ antiporter that drives the uptake of Ca2+ into mitochondria at nanomolar cytosolic Ca2+ concentrations.
Suppression of lung tumorigenesis by leucine zipper/EF hand-containing transmembrane-1.
Cho et al., Seoul, South Korea. In Plos One, 2009
LETM1 suppressed lung cancer cell growth in vitro and in vivo.
Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter.
Clapham et al., Boston, United States. In Science, 2009
Letm1, was found to specifically mediate coupled Ca2+/H+ exchange; RNAi knockdown, overexpression, and liposome reconstitution of the purified Letm1 protein demonstrate that Letm1 is a mitochondrial Ca2+/H+ antiporter
Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death.
Park et al., Taejŏn, South Korea. In Cancer Res, 2009
Data suggest that LETM1 serves as an anchor protein for complex formation with the mitochondrial ribosome and regulates mitochondrial biogenesis. Increased expression of LETM1 in human cancer suggests that dysregulation of LETM1 features in tumorigenesis.
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