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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, adiponectin, fibrillin-1, HAD, AGE
Papers using leptin antibodies
Leptin is the modulator of HSP60 gene expression in AR42J cells
Frühbeck Gema et al., In Mediators of Inflammation, 2005
... The control and pair-fed groups received vehicle (PBS), while leptin-treated mice were intraperitoneally administered with leptin (Bachem, Bubendorf, Switzerland) twice daily ...
A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice.
Calbet Jose A. L., In PLoS ONE, 2004
... were placed under caloric restriction (2 g standard chow diet/day) and were daily injected with recombinant leptin (2 g/kg body weight) (Bachem, Bubendorf, Switzerland) in order ...
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients
Acharya Subrat K. et al., In The Indian Journal of Medical Research, 2003
... : Commercial ELISA assays kits were used to measure serum level of TNFα, IL-1, IL-6, leptin (Cayman Chemical Company, Michigan, USA, ...
PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
Ballock R. Tracy et al., In PPAR Research, 2003
... Tri-iodothyronine (T3, Sigma), leptin (Sigma), and ciglitazone (BioMol, Plymouth Meeting, PA) were ...
Dissecting autocrine effects on pulsatile release of gonadotropin-releasing hormone in cultured rat hypothalamic tissue
Shin Choong Ho et al., In Korean Journal of Pediatrics, 2003
... Recombinant mouse leptin (>98% pure) was purchased from Biodesign International, Meridian Life Science, ...
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Papers on leptin
Decreased adiponectin links elevated adipose tissue autophagy with adipocyte endocrine dysfunction in obesity.
Rudich et al., Beersheba, Israel. In Int J Obes (lond), Feb 2016
SUBJECTS/METHODS: We utilized a large (N=186) human adipose tissue bio-bank to assess clinical associations between human visceral AT autophagy genes, adiponectin and leptin, by multivariate models.
Leptin signalling pathways in hypothalamic neurons.
Kim et al., Seoul, South Korea. In Cell Mol Life Sci, Feb 2016
UNASSIGNED: Leptin is the most critical hormone in the homeostatic regulation of energy balance among those so far discovered.
Gastric ghrelin, GOAT, leptin, and leptinR expression as well as peripheral serotonin are dysregulated in humans with obesity.
Bischoff et al., Stuttgart, Germany. In Neurogastroenterol Motil, Feb 2016
We studied the expression of ghrelin, leptin, and the serotonergic system in stomach tissue and serum of obese and non-obese individuals.
Long-term effects of duodenojejunal bypass on diabetes in Otsuka Long-Evans Tokushima Fatty rats.
Kim et al., Taejŏn, South Korea. In Asian J Surg, Feb 2016
Thereafter, we measured daily body weight, serum levels of glucose and gut hormones such as glucagon-like peptide-1, insulin, and leptin.
Androgen receptor (AR) in cardiovascular diseases.
Chang et al., Rochester, United States. In J Endocrinol, Feb 2016
Finally, androgen/AR plays important roles in contributing to the obesity and insulin/leptin resistance to increase the metabolic syndrome.
Leptin, BMI, and a Metabolic Gene Expression Signature Associated with Clinical Outcome to VEGF Inhibition in Colorectal Cancer.
Barry et al., Macclesfield, United Kingdom. In Cell Metab, Feb 2016
Analyses of samples from a phase III clinical trial in metastatic colorectal cancer testing chemotherapy versus chemotherapy with the small molecule VEGF receptors inhibitor cediranib identified circulating leptin levels, BMI, and a tumor metabolic and angiogenic gene expression signature associated with improved clinical outcome in patients treated with cediranib.
Adipokines, cytokines and body fat stores in hepatitis C virus liver steatosis.
Santolaria-Fernández et al., La Laguna, Spain. In World J Hepatol, Feb 2016
METHODS: We included 56 HCV infected patients, and assessed the amount of liver fat by histomorphometry, and its relationships with fat and lean mass at different parts of the body (by densitometry), hormones [insulin, homeostatic model assessment (HOMA)], adipokines (resistin, adiponectin, leptin), and cytokines (tumor necrosis factor α, interleukin-6).
Biomarkers in the diagnosis and study of psychogenic nonepileptic seizures: A systematic review.
Jimenez et al., Cleveland, United States. In Seizure, Jan 2016
Other miscellaneous biomarkers (neuron specific enolase, brain derived neurotropic factor, ghrelin, leptin, leukocytosis) showed no conclusive evidence of utility.
Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake.
Friedman et al., New York City, United States. In Cell Metab, Jan 2016
Hypothalamic expression of lapp is markedly decreased in ob/ob mice and normalized by exogenous leptin.
Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages.
Shi et al., Boston, United States. In Cell Metab, Jan 2016
Rampant body weight gain in ob/ob mice, a strain that lacks leptin, associates with reduced MC content in WAT.
Microbiota depletion promotes browning of white adipose tissue and reduces obesity.
Trajkovski et al., Genève, Switzerland. In Nat Med, Dec 2015
This leads to improved glucose tolerance and insulin sensitivity and decreased white fat and adipocyte size in lean mice, obese leptin-deficient (ob/ob) mice and high-fat diet (HFD)-fed mice.
Effects of Gestational Magnetic Resonance Imaging on Methylation Status of Leptin Promoter in the Placenta and Cord Blood.
Dou et al., Zhengzhou, China. In Plos One, Dec 2015
Here, we investigated DNA methylation patterns of leptin promoter in the placenta and cord blood of women exposed to MRI during gestation.
Running on Empty: Leptin Signaling in VTA Regulates Reward from Physical Activity.
Kenny et al., New York City, United States. In Cell Metab, Nov 2015
In this issue, Fernandes et al. (2015) show that disruption of leptin-regulated STAT3 signaling in midbrain dopamine neurons increases the rewarding effects of running in mice, which could explain the "high" experienced by endurance runners.
[Genetics of congenital lipodystrophies].
Caron et al., Toulouse, France. In Ann Endocrinol (paris), Oct 2015
Congenital lipodystrophies treatment is based on the management of metabolic comorbidities but recombinant leptin therapy appears to have promising results.
Reactive Oxygen Species in the Paraventricular Nucleus of the Hypothalamus Alter Sympathetic Activity During Metabolic Syndrome.
Braga et al., João Pessoa, Brazil. In Front Physiol, 2014
Chronic sympathetic nerve activation promotes a series of metabolic disorders that characterizes the metabolic syndrome (MetS): dyslipidemia, hyperinsulinemia, glucose intolerance, hyperleptinemia and elevated plasma hormone levels, such as noradrenaline, glucocorticoids, leptin, insulin, and Ang-II.
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.
Bence et al., Philadelphia, United States. In Am J Physiol Endocrinol Metab, 2012
Data suggest that leptin and PTP1B (protein tyrosine phosphatase 1B) are important components in energy balance regulation by pro-opiomelanocortin neurons in hindbrain. PTP1B knockout mice are hypersensitive to administration of leptin to hindbrain.
Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype.
Kraft et al., Durham, United States. In Am J Respir Crit Care Med, 2012
Leptin levels were increased in overweight/obese subjects and were significantly higher in overweight/obese subjects with asthma. Alveolar macrophages from overweight/obese subjects with asthma are uniquely sensitive to leptin.
[Association between leptin gene promoter methylation and type 2 diabetes mellitus].
Li et al., Wuhan, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
The methylation rates of leptin gene in IGR and T2DM groups were 43.6 % and 31.5 %, respectively, which were significantly lower than that of healthy subjects (59.2%; Chi-square=22.499 and 5.109, respectively, P<0.05).
Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers.
Bouslama et al., Sousse, Tunisia. In Genet Test Mol Biomarkers, 2012
LEP G2548A and LEPR Q223R polymorphisms and haplotype combination were associated with MetS and obesity risk in Tunisian volunteers.
Leptin affects insulin action in astrocytes and impairs insulin-mediated physical activity.
Hennige et al., Tübingen, Germany. In Cell Physiol Biochem, 2011
a crosstalk of leptin and insulin in the brain which leads to a decline in locomotor activity
More papers using leptin antibodies
Divergent effects of soy protein diet on the expression of adipocytokines
Naito Michitaka et al., In Journal of Clinical Biochemistry and Nutrition, 2002
An insulin kit was purchased from Sibayagi (Gunma, Japan), a leptin kit was purchased from Biovendor Laboratory Medicine (Brno, Czech ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
Ghribi Othman et al., In Molecular Neurodegeneration, 2000
... Leptin, Aβ42, and rapamycin were purchased from Sigma Aldrich (St ...
Cerebrospinal cytokine levels in patients with acute depression
Dąbrowski Piotr et al., In Mediators of Inflammation, 1998
... Leptin was measured using a commercially available highly sensitive ELISA kits (BioVendor Laboratory Medicine Inc., Czech ...
Expression of cell adhesion molecules in murine placentas and a placental cell line.
Bobé Pierre, In PLoS ONE, 1998
... Plasma leptin levels were measured by ELISA (Cayman Chemical Company, Ann Arbor, ...
The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system.
Calbet Jose A. L., In PLoS ONE, 1987
... The control and pair-fed groups received vehicle (PBS), while leptin-treated groups were intraperitoneally administered with leptin (Bachem, Bubendorf, Switzerland) twice a day ...
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