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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Leptin receptor

leptin receptor, LEPR, OB-R
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: leptin, Insulin, HAD, AGE, fibrillin-1
Papers using leptin receptor antibodies
Regulated internalization of caveolae
Levy Émile et al., In International Journal of Cell Biology, 1993
... Rabbit antibodies against human leptin (A20) and human leptin receptor (H300) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on leptin receptor
Data in support of the discovery of alternative splicing variants of quail LEPR and the evolutionary conservation of qLEPRl by nucleotide and amino acid sequences alignment.
Liu et al., Zhengzhou, China. In Data Brief, Mar 2016
Leptin receptor (LEPR) belongs to the class I cytokine receptor superfamily which share common structural features and signal transduction pathways.
Gastric ghrelin, GOAT, leptin, and leptinR expression as well as peripheral serotonin are dysregulated in humans with obesity.
Bischoff et al., Stuttgart, Germany. In Neurogastroenterol Motil, Feb 2016
Ghrelin, ghrelin O-acyl transferase (GOAT), leptin, leptin receptor, and tryptophan hydroxylase 1 (TPH1) mRNA expression were measured by qRT-PCR.
Panax notoginseng saponins ameliorate impaired arterial vasodilation in SHRSP.Z-Lepr(fa) /lzmDmcr rats with metabolic syndrome.
Shinozuka et al., Beijing, China. In Clin Exp Pharmacol Physiol, Feb 2016
SHRSP.Z-Lepr(fa) /IzmDmcr (SHRSP.ZF) rats, a new animal model for metabolic syndrome, display an impaired vasorelaxation response in aortas and mesenteric arteries that is mediated by nitric oxide (NO).
Fatness rather than leptin sensitivity determines the timing of puberty in female mice.
Donato et al., São Paulo, Brazil. In Mol Cell Endocrinol, Feb 2016
Inactivation of Socs3 gene in the brain or exclusively in leptin receptor-expressing cells reduced the body weight and leptin levels at pubertal onset, and increased leptin sensitivity.
A systematic review of genetic variants associated with metabolic syndrome in patients with schizophrenia.
Seedat et al., Cape Town, South Africa. In Schizophr Res, Jan 2016
Several genes showed strong evidence for an association with MetS in patients with schizophrenia, including the fat mass and obesity associated gene (FTO), leptin and leptin receptor genes (LEP, LEPR), methylenetetrahydrofolate reductase (MTHFR) gene and the serotonin receptor 2C gene (HTR2C).
Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake.
Friedman et al., New York City, United States. In Cell Metab, Jan 2016
In slices, amylin and leptin had similar electrophysiologic effects on lateral hypothalamic leptin receptor ObRb-expressing neurons, while the amylin antagonist AC187 inhibited their activity and blunted the effect of leptin.
Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma.
Pchejetski et al., Amman, Jordan. In Oncotarget, Dec 2015
Both high levels of leptin in circulation and leptin receptor mutation are associated with prostate cancer risk in human patients; however, the in vivo mechanistic evidence is less conclusive.Given the complexity of metabolic cancer pathways, it is possible that leptin may have varying effects on prostate cancer at different stages of its development, a point that may be addressed by further epidemiological studies.
Leptin Suppresses the Rewarding Effects of Running via STAT3 Signaling in Dopamine Neurons.
Fulton et al., Montréal, Canada. In Cell Metab, Nov 2015
Leptin receptor (LepR) signaling involves activation of signal transducer and activator of transcription-3 (STAT3), including in dopamine neurons of the ventral tegmental area (VTA) that are essential for reward-relevant behavior.
Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal.
Morrison et al., Dallas, United States. In Nature, Nov 2015
Nearly all HSCs contacted leptin receptor positive (Lepr(+)) and Cxcl12(high) niche cells, and approximately 85% of HSCs were within 10 μm of a sinusoidal blood vessel.
The soluble leptin receptor.
Kratzsch et al., Leipzig, Germany. In Best Pract Res Clin Endocrinol Metab, Oct 2015
The adipokine leptin realizes signal transduction via four different leptin receptor (OB-R) isoforms.
[Expression of neuropeptide Y and long leptin receptor in gastrointestinal tract of giant panda].
Li et al., In Sheng Wu Gong Cheng Xue Bao, Aug 2015
To study the expression and distribution of neuropeptide Y (NPY) and long leptin receptor (OB-Rb) in the gastrointestinal tract of giant panda, samples of three animals were collected from the key laboratory for reproduction and conservation genetics of endangered wildlife of Sichuan province, China conservation and research center for the giant panda.
The Association of Polymorphisms in Leptin/Leptin Receptor Genes and Ghrelin/Ghrelin Receptor Genes With Overweight/Obesity and the Related Metabolic Disturbances: A Review.
Mirmiran et al., Tehrān, Iran. In Int J Endocrinol Metab, Jul 2015
RESULTS: The most prevalent leptin/leptin receptor genes (LEP/LEPR) and ghrelin/ghrelin receptor genes (GHRL/GHSR) single nucleotide polymorphisms studied were LEP G-2548A, LEPR Q223R, and Leu72Met, respectively.
Diet-induced obese mice retain endogenous leptin action.
Perez-Tilve et al., Cincinnati, United States. In Cell Metab, Jul 2015
To directly determine endogenous leptin activity in obesity, we treated lean and obese mice with a leptin receptor antagonist.
Treatment of obesity with celastrol.
Ozcan et al., Boston, United States. In Cell, Jun 2015
Celastrol suppresses food intake, blocks reduction of energy expenditure, and leads to up to 45% weight loss in hyperleptinemic diet-induced obese (DIO) mice by increasing leptin sensitivity, but it is ineffective in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mouse models.
Chronic Oxytocin Administration as a Treatment Against Impaired Leptin Signaling or Leptin Resistance in Obesity.
Rohner-Jeanrenaud et al., Genève, Switzerland. In Front Endocrinol (lausanne), 2014
Taking into account that oxytocin is located downstream leptin, it was hypothesized that oxytocin treatment would be effective in decreasing body weight in leptin-resistant DIO animals, as well as in those with leptin or with leptin receptor deficiency.
Homozygous deletion of an 80 kb region comprising part of DNAJC6 and LEPR genes on chromosome 1P31.3 is associated with early onset obesity, mental retardation and epilepsy.
Dam et al., Paris, France. In Mol Genet Metab, 2012
the phenotype of individuals with OB-R deficiency and postulates the effects of auxilin-1 deficiency (mental retardation/epilepsy) and endospanin-1 deficiency (OB-R specific functions) in humans.
Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers.
Bouslama et al., Sousse, Tunisia. In Genet Test Mol Biomarkers, 2012
LEP G2548A and LEPR Q223R polymorphisms and haplotype combination were associated with MetS and obesity risk in Tunisian volunteers.
Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action.
Kratzsch et al., Leipzig, Germany. In Plos One, 2011
Using siRNA knockdown experiments the study identified ADAM10 (A Disintegrin And Metalloproteinase 10) as a major protease for constitutive and activated OB-R cleavage.
Normal leptin expression, lower adipogenic ability, decreased leptin receptor and hyposensitivity to Leptin in Adolescent Idiopathic Scoliosis.
Huang et al., Guangzhou, China. In Plos One, 2011
decreased leptin receptor levels may lead to the hyposensitivity to leptin. These findings implied that abnormal peripheral leptin signaling plays an important role in the pathological mechanism of AIS
Leptin receptor gene K656N polymorphism is associated with low body fat levels and elevated high-density cholesterol levels in Mexican children and adolescents.
Castro et al., Colima, Mexico. In Endocr Res, 2011
results suggest that there is no association between the K109R, Q223R, and K656N polymorphisms of the leptin receptor gene with obesity in this Mexican population
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