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Left right determination factor 1

Lefty1, Lefty, LEFTB
This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NODAL, lefty2, TGF-beta, CAN, RGS
Papers on Lefty1
Microarray Analyses Reveal Marked Differences in Growth Factor and Receptor Expression Between 8-Cell Human Embryos and Pluripotent Stem Cells.
Kiessling et al., Athens, Greece. In Stem Cells Dev, Feb 2016
Forty-four gene elements were underdetected on the 8C arrays, including 11 at least 80-fold under the pluripotent cells: two cytokines (IFITM1, TNFRSF8), five TGFBs (BMP7, LEFTY1, LEFTY2, TDGF1, TDGF3), two FGFs (FGF2, FGF receptor 1), plus ING5, and WNT6.
Lefty1 alleviates renal tubulointerstitial injury in mice with unilateral ureteral obstruction.
Zhang et al., Wuhan, China. In Mol Med Report, Jan 2016
Lefty is a member of the transforming growth factor (TGF) β superfamily, which is implicated in left‑right patterning during embryogenesis.
A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain.
Hill et al., London, United Kingdom. In Dev Cell, Nov 2015
The morphogen Nodal was proposed to form a long-range signaling gradient via a reaction-diffusion system, on the basis of differential diffusion rates of Nodal and its antagonist Lefty.
Mechanisms of the epithelial-to-mesenchymal transition in sea urchin embryos.
Katow, Aomori, Japan. In Tissue Barriers, Oct 2015
Acquisition of cell motility after EMT in these mesenchyme cells is associated with the expression of proteins such as Lefty, Snail and Seawi.
Characterization and genomic structure of Dnah9, and its roles in nodal signaling pathways in the Japanese flounder (Paralichthys olivaceus).
Qi et al., Qingdao, China. In Fish Physiol Biochem, Oct 2015
Furthermore, after nodal signaling was inhibited, the level of Southpaw did not change significantly at early development stage (50 % epiboly) but increased significantly at late stages (27-somite stages and 1 DAH), as well as the expression of Lefty, an inhibitor of nodal signaling, increased continuously.
Overview of Transforming Growth Factor β Superfamily Involvement in Glioblastoma Initiation and Progression.
Lin et al., Taipei, Taiwan. In Asian Pac J Cancer Prev, 2014
The transforming growth factor β (TGFβ) superfamily is a large group of structurally related proteins including TGFβ subfamily members Nodal, Activin, Lefty, bone morphogenetic proteins (BMPs) and growth and differentiation factor (GDF).
Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology.
Tolar et al., Minneapolis, United States. In Bmc Cancer, 2014
Using the MIC, we identified correlations across the data features, including six major hubs with higher expression in YST (LEFTY1, LEFTY2, miR302b, miR302a, miR 126, and miR 122) compared with other GCT.
TGFβ signaling in establishing left-right asymmetry.
Hamada et al., Ōsaka, Japan. In Semin Cell Dev Biol, 2014
Two TGFβ-related proteins, Nodal and Lefty, are asymmetrically expressed and play central roles in establishing left-right (L-R) asymmetry of our body.
Reviewing and updating the major molecular markers for stem cells.
Bonatto et al., Porto Alegre, Brazil. In Stem Cells Dev, 2013
The commonly cited markers for embryonic ESCs are Nanog, Oct-4, Sox-2, Rex-1, Dnmt3b, Lin-28, Tdgf1, FoxD3, Tert, Utf-1, Gal, Cx43, Gdf3, Gtcm1, Terf1, Terf2, Lefty A, and Lefty B. MSCs are primarily identified by the expression of CD13, CD29, CD44, CD49e, CD54, CD71, CD73, CD90, CD105, CD106, CD166, and HLA-ABC and lack CD14, CD31, CD34, CD45, CD62E, CD62L, CD62P, and HLA-DR expression.
Transforming growth factor β and Ras/MEK/ERK signaling regulate the expression level of a novel tumor suppressor Lefty.
Hibi et al., Tokyo, Japan. In Pancreas, 2012
Data suggest that Lefty is a novel TGF-beta target molecule that mediates growth inhibition of pancreatic cancer cells.
Differential diffusivity of Nodal and Lefty underlies a reaction-diffusion patterning system.
Schier et al., Cambridge, United States. In Science, 2012
results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning
Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish.
Burdine et al., Princeton, United States. In Development, 2011
Bmp represses Nodal signaling independently of lefty1 expression and through the activity of a ligand other than Bmp4.
Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafish.
Bakkers et al., Utrecht, Netherlands. In Plos Genet, 2011
both Nodal and Bmp independently are required for lefty1 expression to assure unilateral Nodal activation and correct LR patterning
Isolation, characterization, and function of EBAF/LEFTY B: role in infertility.
Tabibzadeh, Stony Brook, United States. In Ann N Y Acad Sci, 2011
Findings show that during embryonic development, EBAF/LEFTY B plays important roles in decidualization and embryo implantation.
Left-right asymmetry in embryonic development and breast cancer: common molecular determinants?
Hagedorn et al., Göttingen, Germany. In Curr Med Chem, 2010
Several secreted and membrane-bound growth factors such as Nodal, Lefty, FGF, HB-EGF and HGF as well as transcription factors (e.g.
Establishment of vertebrate left-right asymmetry.
Saijoh et al., Ōsaka, Japan. In Nat Rev Genet, 2002
Until recently, the molecular basis of left-right asymmetry was a mystery, but studies indicate that Nodal and the Lefty proteins, transforming growth factor-beta-related molecules, have a central role in generating asymmetric signals.
Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects.
Casey et al., Bethesda, United States. In Nat Genet, 2000
Several genes (such as Nodal, Ebaf and Pitx2) have been implicated in L-R organ positioning in model organisms.
N-Cadherin, a cell adhesion molecule involved in establishment of embryonic left-right asymmetry.
Bronner-Fraser et al., Pasadena, United States. In Science, 2000
However, the expression of other components of this cascade (Nodal and Lefty) was unchanged after blocking N-cadherin function, suggesting the existence of parallel pathways in the establishment of left-right morphogenesis.
Regulation of left-right patterning in mice by growth/differentiation factor-1.
Lee et al., Baltimore, United States. In Nat Genet, 2000
In most Gdf1-/- embryos, the expression of Ebaf (formerly lefty-1) in the left side of the floor plate and Leftb (formerly lefty-2), nodal and Pitx2 in the left lateral plate mesoderm was absent, suggesting that Gdf1 acts upstream of these genes either directly or indirectly to activate their expression.
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