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Lactate dehydrogenase C

LDH-X, LDH3, LDH-C, lactate dehydrogenase C
Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: LDH-B, HAD, ACID, CAN, MEN
Papers on LDH-X
Enzymatic Kinetic Properties of the Lactate Dehydrogenase Isoenzyme C₄ of the Plateau Pika (Ochotona curzoniae).
Wei et al., Xining, China. In Int J Mol Sci, Dec 2015
Testis-specific lactate dehydrogenase (LDH-C₄) is one of the lactate dehydrogenase (LDH) isozymes that catalyze the terminal reaction of pyruvate to lactate in the glycolytic pathway.
Yeast cell-based analysis of human lactate dehydrogenase isoforms.
Nakanishi et al., Tokyo, Japan. In J Biochem, Dec 2015
Similarly, introduction of the human LDHC complemented the pdc growth defect, even though LDHC did not generate lactate at the levels seen with LDHA.
Influence of perfusate on liver viability during hypothermic machine perfusion.
Zheng et al., Hangzhou, China. In World J Gastroenterol, Sep 2015
RESULTS: Comparison of HMP and SCS: Regardless of the perfusate, HMP improved the architecture of donor graft in reducing the congestion around sinusoids and central vein and maintaining sinusoid lining in morphology; HMP improved liver function in terms of ALT, AST and LDH, especially during the 3-6 h period (SCS vs HMP using saline: ALT3, 225.00 ± 105.62 vs 49.50 ± 18.50, P = 0.047; LDH3, 1362.17 ± 563.30 vs 325.75 ± 147.43, P = 0.041; UW: LDH6, 2880.14 ± 948.46 vs 2135.00 ± 174.27, P = 0.049; HTK, AST6, 307.50 ± 52.95 vs 185.20 ± 20.46, P = 0.041); HMP decreased MDA level (saline, 2.79 ± 0.30 vs 1.09 ± 0.09, P = 0.008; UW, 3.01 ± 0.77 vs 1.23 ± 0.68, P = 0.005; HTK, 3.30 ± 0.52 vs 1.56 ± 0.22, P = 0.006).
Testis-Specific Lactate Dehydrogenase (LDH-C4) in Skeletal Muscle Enhances Apika's Sprint-Running Capacity in Hypoxic Environment.
Wei et al., Xining, China. In Int J Environ Res Public Health, Aug 2015
In mammals, ldh-c was originally thought to be expressed only in testis and spermatozoa.
[The expression of the sperm-specific lactate dehydrogenase gene Ldh-c in plateau pika (Ochotona curzoniae) cardiac muscle and its effect on the anaerobic glycolysis].
Wei et al., Xining, China. In Sheng Li Xue Bao, Jul 2015
We found that the sperm-specific lactate dehydrogenase (LDH-C4) gene Ldh-c expressed in plateau pika cardiac muscle.
Comparative proteomic analysis of spermatozoa isolated by swim-up or density gradient centrifugation.
Ricci et al., Trieste, Italy. In Reprod Biol Endocrinol, 2014
One DC>SU spot contained lactate dehydrogenase C and gamma-glutamylhydrolase, a second DC>SU spot contained fumarate hydratase and glyceraldehyde-3-phosphate dehydrogenase-2, and a SU>DC spot contained pyruvate kinase M1/M2.
Enzymes involved in l-lactate metabolism in humans.
Donapetry et al., A Coruña, Spain. In Mitochondrion, 2013
The LDHC gene is expressed in a broad range of tumors.
LDH-C4: a target with therapeutic potential for cancer and contraception.
Gupta, Chandīgarh, India. In Mol Cell Biochem, 2012
Though, originally considered to be testis specific, LDH-C or Ldh3 in mice was later detected in the murine oocyte and early embryo.
Evaluation of multiple serum markers in advanced melanoma.
González et al., Pamplona, Spain. In Tumour Biol, 2011
Results show that S-100B, MIA and LDH levels were significantly higher in patients with advanced melanoma than in disease-free patients or healthy controls.
Lactate dehydrogenase C and energy metabolism in mouse sperm.
Eddy et al., United States. In Biol Reprod, 2011
part of a complex involved in ATP homeostasis in sperm
Elevated serum lactate dehydrogenase isoenzymes and aspartate transaminase distinguish Albers-Schönberg disease (Chloride Channel 7 Deficiency Osteopetrosis) among the sclerosing bone disorders.
Wenkert et al., Saint Louis, United States. In J Bone Miner Res, 2010
Elevated serum LDH isoenzymes and AST indicate a disturbance (of uncertain clinical significance) within multiple extraosseous tissues when there is CLCN7 deficiency.
LDHC: the ultimate testis-specific gene.
Odet et al., Evanston, United States. In J Androl, 2010
required for sperm to accomplish fertilization
Homo sapiens lactate dehydrogenase c (Ldhc) gene expression in cancer cells is regulated by transcription factor Sp1, CREB, and CpG island methylation.
Goldberg et al., Evanston, United States. In J Androl, 2009
hLdhc expression in cancer cells was regulated by transcription factor Sp1 and CREB and promoter CGI methylation
[Advances in researches on lactate dehydrogenase-C4 isozyme].
Lan et al., Fuzhou, China. In Zhonghua Nan Ke Xue, 2003
Developmental and testis-specific expression of the LDH-C gene requires mechanisms for activation in germ cells and repression in somatic cells.
Methods for the separation of lactate dehydrogenases and clinical significance of the enzyme.
Kirchberger et al., Leipzig, Germany. In J Chromatogr B Biomed Appl, 1996
In mammals, three types of subunits encoded by the genes Ldh-A, Ldh-B and Ldh-C give rise to a selected number of tetrameric isoenzymes.
Lactate dehydrogenase X: effects of antibody on mouse gametes but not on early development.
Epstein et al., In Science, 1975
A rabbit antiserum specific for LDH-X, the spermatozoal form of mouse lactate dehydrogenase, was prepared.
Infertility in female rabbits immunized with lactate dehydrogenase X.
Goldberg, In Science, 1973
Immunization of female rabbits with the sperm-specific lactate dehydrogenase (LDH-X) resulted in a highly significant reduction of pregnancies compared to nonimmunized controls.
Pregnancy suppression by an antiserum to the sperm specific lactate dehydrogenase.
Lerum et al., In Science, 1972
An antiserum induced against the isozyme of lactate dehydrogenase (LDH-X) that is unique to spermatozoa reduced significantly the number of pregnancies in mice treated at varying times after they had mated.
Lactate dehydrogenase isozyme patterns of human platelets and bovine lens fibers.
Vesell, In Science, 1966
Human platelets and bovine lens fibers contain lactate dehydrogenase-3 (LDH-3) as the predominant isozyme but only very faint traces of LDH-5.
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