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Clathrin, light chain A

LCa, CLTA, clathrin light chain LCa
light chain component of the clathrin triskelion structure of coated vesicles [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: LCB, CAN, ACID, CTLA-4, V1a
Papers using LCa antibodies
Single-Virus Tracking in Live Cells.
Farzan Michael, In PLoS Pathogens, 2007
... BS-C-1 cells stably expressing LCa-YFP were created by use of the RetroMax retroviral expression system (Imgenex, San Diego, CA, USA) ...
Papers on LCa
Rosuvastatin Alleviates Type 2 Diabetic Atrial Structural and Calcium Channel Remodeling.
Li et al., Shenyang, China. In J Cardiovasc Pharmacol, Jan 2016
The expression of Cav1.2, Cav3.1, and Cav3.2 in atrial tissues was detected by real-time reverse transcriptase polymerase chain reaction and Western blot, and inward calcium currents (lCa-L and lCa-T) were recorded in isolated atrial myocytes using patch-clamp techniques.
Induction of Inhibitory Receptors on T Cells During Plasmodium vivax Malaria Impairs Cytokine Production.
Antonelli et al., Porto Velho, Brazil. In J Infect Dis, Jan 2016
Importantly, simultaneously blockade of the CLTA-4, PD-1, and T-cell immunoglobulin and mucin-3 signaling restores the cytokine production by antigen-specific cells.
Effect of a mixture of GOS/FOS(®) on calcium absorption and retention during recovery from protein malnutrition: experimental model in growing rats.
Zeni et al., Buenos Aires, Argentina. In Eur J Nutr, Oct 2015
PURPOSE: The effect of a mixture of GOS/FOS(®) 9:1 added to a 0.5 %Ca (NCa) and a 0.3 %Ca (LCa) diets on Ca, P and Mg absorptions and bone mineralization, density and structure using an experimental model of growing rats recovering from early protein malnutrition was investigated.
Unexpected transcellular protein crossover occurs during canonical DNA transfection.
Davletov et al., Cambridge, United Kingdom. In J Cell Biochem, 2014
Here, we demonstrate that Neuro2A cells transfected using Lipofectamine LTX with the fluorescently coupled Botulinum serotype A holoenzyme (EGFP-LcA) cDNA express this SNAP25 protease that can, once translated, escape the transfected host cytosol and become endocytosed into untransfected cells, without its innate binding and translocation domains.
Expression of YKL-40 and MIP-1a proteins in exudates and transudates: biomarkers for differential diagnosis of pleural effusions? A pilot study.
Schiza et al., Nicosia, Cyprus. In Bmc Pulm Med, 2014
Exudates were further classified based on the underlying disease: ten with tuberculosis (TB), 13 with lung cancer (LCa), 15 with metastatic cancer (MCa) of non-lung origin and 11 with parapneumonic (PN) effusions.
A graphene oxide based fluorescence resonance energy transfer (FRET) biosensor for ultrasensitive detection of botulinum neurotoxin A (BoNT/A) enzymatic activity.
Yang et al., Hong Kong, Hong Kong. In Biosens Bioelectron, 2014
We report the construction of a novel graphene oxide (GO)-peptide based fluorescence resonance energy transfer (FRET) biosensor for ultrasensitive detection of the BoNT serotype A light chain (BoNT-LcA) protease activity.
Cloning of cDNAs for H1F0, TOP1, CLTA and CDK1 and the effects of cryopreservation on the expression of their mRNA transcripts in yak (Bos grunniens) oocytes.
Wang et al., Chengdu, China. In Cryobiology, 2014
INTRODUCTION: We cloned and sequenced four pivotal cDNAs involved in DNA structural maintenance (H1F0 and TOP1) and the cell cycle (CLTA and CDK1) from yak oocytes.
Brainstem neurons responsible for postural, masseter or pharyngeal muscle atonia during paradoxical sleep in freely-moving cats.
Neuzeret et al., Lyon, France. In Arch Ital Biol, 2011
The PS/atonia-on neurons, characterized by their most slow conducting property and located in the peri-locus coeruleus alpha (peri-LCa) and adjacent LCa of the mediodorsal pontine tegmentum, play a critical executive role in the somatic and orofacial muscle atonia observed during PS.
IGF1R signaling in Ewing sarcoma is shaped by clathrin-/caveolin-dependent endocytosis.
de Alava et al., Salamanca, Spain. In Plos One, 2010
IGF1R internalization and co-localization with clathrin and CAV1 upon ligand binding, as well as the status of the IGF1R pathway, cellular proliferation, and the apoptosis of interfered and inhibited Ewing's sarcoma, were analyzed.
Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis.
Schmid et al., Los Angeles, United States. In J Cell Biol, 2010
The results underscore the highly dynamic and cargo-responsive nature of CCP assembly and suggest that the observed heterogeneity is, in part, related to compositional differences (e.g., cargo and adaptors) between CCPs.
Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.
Harrison et al., Boston, United States. In Embo J, 2010
Structure of clathrin coat with bound Hsc70 and auxilin.
Novel immunotherapies as potential therapeutic partners for traditional or targeted agents: cytotoxic T-lymphocyte antigen-4 blockade in advanced melanoma.
Agarwala, Bethlehem, United States. In Melanoma Res, 2010
The pivotal role of CTLA-4 in regulating T-cell function is established, and a series of preclinical studies provided proof-of-concept evidence of the antitumor activity of anti-CLTA-4 antibodies in combination with vaccines or chemotherapy.
The mitotic arrest deficient protein MAD2B interacts with the clathrin light chain A during mitosis.
van Kessel et al., Nijmegen, Netherlands. In Plos One, 2009
Data show that MAD2B interacts with CLTA during the G2/M phase of the cell cycle and that depletion of MAD2B leads to a marked increase in the percentage of misaligned chromosomes and a redistribution of CLTA during mitosis.
Ligand-induced tyrosine phosphorylation of cysteinyl leukotriene receptor 1 triggers internalization and signaling in intestinal epithelial cells.
Sjölander et al., Malmö, Sweden. In Plos One, 2009
upon ligand activation, CysLT(1)R is tyrosine-phosphorylated and released from heterodimers with CysLT(2)R and, subsequently, internalizes from the plasma membrane to the nuclear membrane in a clathrin-, arrestin-3-, and Rab-5-dependent manner
The peptidoglycan recognition proteins LCa and LCx.
Deisenhofer et al., Boulder, United States. In Cell Mol Life Sci, 2007
Recent X-ray crystallographic studies of the peptidoglycan recognition proteins LCa, and LCx bound to peptidoglycan have provided structural insights into recognition of peptidoglycan and activation of innate immunity in insects.
Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor.
Deisenhofer et al., Dallas, United States. In Science, 2006
It induces the heterodimerization of its recognition receptors, the peptidoglycan recognition proteins (PGRPs) LCa and LCx, which activates the immune deficiency pathway.
Uncoating protein (hsc70) binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis.
Hill et al., Stanford, United States. In Cell, 1990
Uncoating of clathrin-coated vesicles is mediated by the heat shock cognate protein, hsc70, and requires clathrin light chains (LCa and LCb) and ATP hydrolysis.
Electrophysiologic aspects of moricizine HCl.
Burnashev et al., Moscow, Russia. In Am J Cardiol, 1987
At the same dose, the slow inward calcium current (lCa) increased, but the total outward current did not change.
Clathrin light chains contain brain-specific insertion sequences and a region of homology with intermediate filaments.
Parham et al., In Nature, 1987
Light chains LCa and LCb are homologous proteins encoded by different genes.
Localization of clathrin light-chain sequences mediating heavy-chain binding and coated vesicle diversity.
Parham et al., In Nature, 1987
This molecular variability derives from tissue-specific patterns of expression of LCa and LCb genes.
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