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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

La ribonucleoprotein domain family, member 7

LARP7, DKFZp564K112, PIP7S
Top mentioned proteins: POLYMERASE, BCDIN3, Inactive, V1a, CAN
Papers on LARP7
Compound heterozygous variants in the LARP7 gene as a cause of Alazami syndrome in a Caucasian female with significant failure to thrive, short stature, and developmental disability.
Sorrentino et al., Los Angeles, United States. In Am J Med Genet A, Jan 2016
Whole exome sequencing (WES) identified two novel pathogenic variants in LARP7 (c.213_214dup and c.651_655del), indicating a diagnosis of Alazami syndrome.
CDK9 and its repressor LARP7 modulate cardiomyocyte proliferation and response to injury in the zebrafish heart.
Denvir et al., Houston, United States. In J Cell Sci, Jan 2016
In contrast, de-repression of Cdk9 activity, through knockdown of La-related protein (Larp7) increases phosphorylation of Ser2 in RNA polymerase II and increases cardiomyocyte proliferation.
The miR-302/367 cluster: a comprehensive update on its evolution and functions.
Dou et al., Lanzhou, China. In Open Biol, Dec 2015
The miR-302/367 cluster, generally consisting of five members, miR-367, miR-302d, miR-302a, miR-302c and miR-302b, is ubiquitously distributed in vertebrates and occupies an intragenic cluster located in the gene La-related protein 7 (LARP7).
Broadening the phenotypic spectrum of pathogenic LARP7 variants: two cases with intellectual disability, variable growth retardation and distinct facial features.
van de Laar et al., Rotterdam, Netherlands. In J Hum Genet, Dec 2015
A homozygous frameshift mutation in LARP7, a chaperone of the noncoding RNA 7SK, was discovered in patients from a single consanguineous Saudi family.
Intermolecular recognition of the non-coding RNA 7SK and HEXIM protein in perspective.
Dock-Bregeon et al., Illkirch-Graffenstaden, France. In Biochimie, Oct 2015
A 7SKsnRNP complex, comprising the non-coding RNA 7SK and proteins MePCE and LARP7, participates in the regulation of the transcription elongation by RNA-polymerase II in higher eukaryotes.
Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7.
Dock-Bregeon et al., Strasbourg, France. In Nucleic Acids Res, May 2015
The La-related protein LARP7 is a component of the 7SKsnRNP required for stability and function of the RNA.
The La-Related Proteins, a Family with Connections to Cancer.
Blagden et al., Oxford, United Kingdom. In Biomolecules, 2014
The evolutionarily-conserved La-related protein (LARP) family currently comprises Genuine La, LARP1, LARP1b, LARP4, LARP4b, LARP6 and LARP7.
Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation.
Li et al., Chengdu, China. In Cell Rep, 2014
Loss-of-function germline mutations in La ribonucleoprotein domain family, member 7 (LAPR7) have recently been linked to PD. Paradoxically, LARP7 deficiency was previously assumed to be associated with increased cell growth and proliferation via activation of positive transcription elongation factor b (P-TEFb).
Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.
Peterlin et al., San Francisco, United States. In J Biol Chem, 2014
In the latter, it is inhibited by HEXIM1 or HEXIM2 in the 7SK small nuclear ribonucleoprotein (snRNP), which contains, additionally, 7SK snRNA, methyl phosphate-capping enzyme (MePCE), and La-related protein 7 (LARP7).
LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis.
Luo et al., Berkeley, United States. In Elife, 2013
A reservoir of P-TEFb is sequestered in the inactive 7SK snRNP where 7SK snRNA and the La-related protein LARP7 are required for the integrity of this complex.
xRRM: a new class of RRM found in the telomerase La family protein p65.
Feigon et al., Los Angeles, United States. In Rna Biol, 2013
Genuine La and La-related proteins group 7 (LARP7) bind to the non-coding RNAs transcribed by RNA polymerase III (RNAPIII), which end in UUU-3'OH.
Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism.
Alkuraya et al., Riyadh, Saudi Arabia. In Hum Mutat, 2012
Analysis reveals a novel underlying mechanism for PD involving depletion of 7SK, an abundant cellular noncoding RNA (ncRNA), due to mutation of its chaperone LARP7.
Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65.
Feigon et al., Los Angeles, United States. In Mol Cell, 2012
Additionally, our studies define a structurally homologous domain (xRRM) in genuine La and LARP7 proteins and suggest a general mode of RNA binding for biogenesis of their diverse RNA targets.
LARP7 is a potential tumor suppressor gene in gastric cancer.
Mori et al., Baltimore, United States. In Lab Invest, 2012
LARP7 downregulation occurs early during gastric tumorigenesis and may promote gastric tumorigenesis via p-TEFb dysregulation.
7SK snRNA-mediated, gene-specific cooperativity of HMGA1 and P-TEFb.
Benecke et al., France. In Rna Biol, 2011
7SK RNA thus establishes gene-dependent plasticity between HMGA1 chromatin remodeling and transcription initiation and P-TEFb transcription elongation.
Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction.
Karn et al., Cleveland, United States. In J Virol, 2010
A combination of restrictive chromatin structures at the HIV long terminal repeat and limiting P-TEFb levels contribute to transcriptional silencing leading to latency in primary CD4(+) T cells.
Conserved and divergent features of the structure and function of La and La-related proteins (LARPs).
Maraia et al., Toronto, Canada. In Biochim Biophys Acta, 2010
Recent studies of members of distinct families of conserved La-related proteins (LARPs) indicate that some of these harbor activity related to genuine La proteins, suggesting that their UUU-3'OH binding mode has been appropriated for the assembly and regulation of a specific snRNP (e.g., 7SK snRNP assembly by hLARP7/PIP7S).
7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor.
Bensaude et al., Paris, France. In Rna Biol, 2009
It is stabilized by mono-methylation of its 5'-triphosphate group and binding of a specific La-Related protein, LARP7 at its 3' end.
The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes.
Fischer et al., Würzburg, Germany. In Embo Rep, 2008
Results suggest that LARP7 is a negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system.
LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated.
Price et al., Iowa City, United States. In Nucleic Acids Res, 2008
Results indicate LARP7 is a 7SK-binding protein.
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