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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

RNA binding motif protein 4

Lark, RBM4, RNA-binding motif protein 4
Top mentioned proteins: CAN, CLOCK, ACID, V1a, miR
Papers on Lark
The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells.
Lin et al., Taipei, Taiwan. In Oncotarget, Dec 2015
Herein, we report that the upregulated miR-92a reduced the RNA-binding motif 4 (RBM4) protein expression, leading to the imbalanced expression of the neuronal polypyrimidine tract-binding (nPTB) protein through alternative splicing-coupled nonsense mediated decay (NMD) mechanism.
Identification of a naturally processed HLA-Cw7-binding peptide that cross-reacts with HLA-A24-restricted ovarian cancer-specific CTLs.
Kuzushima et al., Nagoya, Japan. In Tissue Antigens, Sep 2015
Expression screening using a complementary DNA library constructed from TOV21G messenger RNA revealed that this alloreactivity was mediated through the nine-mer peptide VRTPYTMSY, derived from RNA-binding motif protein 4. To our knowledge, this study presents the first example of the allorecognition of an HLA-Cw molecule by HLA-A-restricted T-cells, thereby revealing a naturally processed epitope peptide.
Alanine repeats influence protein localization in splicing speckles and paraspeckles.
Tarn et al., Taipei, Taiwan. In Nucleic Acids Res, 2015
Mammalian splicing regulatory protein RNA-binding motif protein 4 (RBM4) has an alanine repeat-containing C-terminal domain (CAD) that confers both nuclear- and splicing speckle-targeting activities.
A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells.
Raulet et al., Berkeley, United States. In Elife, 2014
Deeper investigation of selected hits from the screen showed that the transcription factor ATF4 drives ULBP1 gene expression in cancer cell lines, while the RNA-binding protein RBM4 supports ULBP1 expression by suppressing a novel alternatively spliced isoform of ULBP1 mRNA.
RBM4-MEF2C network constitutes a feed-forward circuit that facilitates the differentiation of brown adipocytes.
Lin, Taipei, Taiwan. In Rna Biol, 2014
During the differentiation of brown adipocytes, upregulated RBM4 enhanced skipping of the MEF2Cγ region which functions as a transcriptional repressor.
Processing Body Formation Limits Proinflammatory Cytokine Synthesis in Endotoxin-Tolerant Monocytes and Murine Septic Macrophages.
El Gazzar et al., Johnson City, United States. In J Innate Immun, 2014
While transcription repression requires chromatin modifications, a translational repressor complex of Argonaute 2 (Ago2) and RNA-binding motif protein 4 (RBM4), which bind the 3'-UTR of TNFα and IL-6 mRNA, limits protein synthesis.
RBM4-regulated alternative splicing suppresses tumorigenesis.
In Cancer Discov, 2014
RBM4 inhibits cancer cell growth and migration by regulating cancer-associated gene splicing.
Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.
Li et al., Taipei, Taiwan. In Rna, 2014
In this study, we observed a correlation between the cytoplasmic accumulation of RNA-binding motif protein 4 (RBM4) and up-regulated SRPK1 in breast cancer cells.
The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression.
Wang et al., Dalian, China. In Cancer Cell, 2014
Here we report that the splicing factor RBM4 suppresses proliferation and migration of various cancer cells by specifically controlling cancer-related splicing.
Translational regulation of the DOUBLETIME/CKIδ/ε kinase by LARK contributes to circadian period modulation.
Jackson et al., New York City, United States. In Plos Genet, 2014
In this study, we show that translation of dbt transcripts are directly regulated by a rhythmic RNA-binding protein (RBP) called LARK (known as RBM4 in mammals).
Emerging role for RNA binding motif protein 4 in the development of brown adipocytes.
Hsieh et al., Taipei, Taiwan. In Biochim Biophys Acta, 2014
RNA-binding motif protein 4 (RBM4) reportedly reprograms the tissue-specific splicing network which modulates the development of muscles and pancreatic β-islets.
An oxygen-regulated switch in the protein synthesis machinery.
Lee et al., Ottawa, Canada. In Nature, 2012
We show that hypoxia stimulates the formation of a complex that includes the oxygen-regulated hypoxia-inducible factor 2α (HIF-2α), the RNA-binding protein RBM4 and the cap-binding eIF4E2, an eIF4E homologue.
Cellular requirements for LARK in the Drosophila circadian system.
Jackson et al., Boston, United States. In J Biol Rhythms, 2012
LARK is required in the Drosophila circadian system
Multiple roles of RBM4 in muscle cell differentiation.
Tarn et al., Taipei, Taiwan. In Front Biosci (schol Ed), 2011
The multi-functional RNA binding motif 4 (RBM4) protein participates in both precursor mRNA splicing regulation and translational control in muscle cells.
RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing.
Tarn et al., Taipei, Taiwan. In J Cell Biol, 2011
RBM4 may synergize its effect on muscle cell-specific alternative splicing by down-regulating PTB expression and antagonizing the activity of PTB in exon selection
RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation.
Tarn et al., Taipei, Taiwan. In J Biol Chem, 2010
Data show that RBM4 interacts directly with Ago2 during muscle cell differentiation and may recruit Ago2 to suppress translation of target mRNAs.
Functional pre- mRNA trans-splicing of coactivator CoAA and corepressor RBM4 during stem/progenitor cell differentiation.
Ko et al., Augusta, United States. In J Biol Chem, 2009
The alternative splicing imbalance of CoAA and RBM4, because of loss of their common enhancer in cancer, may deregulate stem/progenitor cell differentiation
Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins.
Hughes et al., Toronto, Canada. In Nat Biotechnol, 2009
We tested RNAcompete by analyzing nine diverse RBPs (HuR, Vts1, FUSIP1, PTB, U1A, SF2/ASF, SLM2, RBM4 and YB1).
Altered LARK expression perturbs development and physiology of the Drosophila PDF clock neurons.
Jackson et al., Boston, United States. In Mol Cell Neurosci, 2009
Data show that increased LARK expression during development dramatically alters the small LNv class of pigment-dispersing factor (PDF)-containing neurons with no obvious effects on the large LNv cells.
RBM4: a multifunctional RNA-binding protein.
Morris et al., Sydney, Australia. In Int J Biochem Cell Biol, 2009
RBM4 is an RNA-binding protein involved in diverse cellular processes that include alternative splicing of pre-mRNA, translation, and RNA silencing.
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