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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Centromere protein J

LAP, LIP1, CENPJ, Lias, lipoic acid synthase
This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, aminopeptidase, HAD, TGF-beta
Papers using LAP antibodies
C/EBPβ modulates the early events of keratinocyte differentiation involving growth arrest and keratin 1 and keratin 10 expression
Bissell Mina J. et al., In The Journal of Cell Biology, 1998
... LIP and LAP under control of a tetracycline-repressible promoter, cDNAs were isolated from cytomegalovirus (CMV)–LIP and CMV–LAP constructs and were cloned into the EcoRI site of the eukaryotic expression vector pTetT-Splice (Life Technologies).
Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.
Klefstrom Juha, In PLoS ONE, 1995
... The LAP-tTA transgenic line was kindly provided ...
Papers on LAP
Aged Garlic Extract Reduces Low Attenuation Plaque in Coronary Arteries of Patients with Metabolic Syndrome in a Prospective Randomized Double-Blind Study.
Budoff et al., Torrance, United States. In J Nutr, Feb 2016
Coronary plaque volume, including total plaque volume (TPV), dense calcium (DC), NCP, and low-attenuation plaque (LAP), were measured based upon predefined intensity cutoff values.
Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity.
Chamilos et al., Irákleion, Greece. In Cell Host Microbe, Feb 2016
Accordingly, β-glucan surface exposure during Aspergillus fumigatus germination activates an Atg5-dependent autophagy pathway termed LC3-associated phagocytosis (LAP), which promotes fungal killing.
The impact of left atrial pressure on filtered P-wave duration in patients with atrial fibrillation.
Masuyama et al., Nishinomiya, Japan. In Heart Vessels, Feb 2016
We investigated whether FPD is associated with left atrial pressure (LAP) in AF patients without prominent LA enlargement.
Overexpression of Candida rugosa lipase Lip1 via combined strategies in Pichia pastoris.
Yan et al., Wuhan, China. In Enzyme Microb Technol, Jan 2016
In this study, combined strategies were employed to heterologously overexpress Candida rugosa lipase Lip1 (CRL1) in a Pichia pastoris system.
[Camurati-Engelmann disease].
Kinoshita, In Nihon Rinsho, Dec 2015
Mutations in latency associated peptide(LAP) domain of TGF-β1 destabilize the complex and may hyperactivate TGF signal pathway.
Expression of the Receptor for Advanced Glycation End Products in Epicardial Fat: Link with Tissue Thickness and Local Insulin Resistance in Coronary Artery Disease.
Corsi Romanelli et al., Milano, Italy. In J Diabetes Res, Dec 2015
BMI, HOMA-IR, and LAP indices were calculated.
Latent TGF-β-binding proteins.
Rifkin et al., New York City, United States. In Matrix Biol, Sep 2015
The LTBPs were first identified as forming latent complexes with TGFβ by covalently binding the TGFβ propeptide (LAP) via disulfide bonds in the endoplasmic reticulum.
Rubicon swaps autophagy for LAP.
Randow et al., Cambridge, United Kingdom. In Nat Cell Biol, Jul 2015
Phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called LC3-associated phagocytosis (LAP).
New insights into the role of sex steroid hormones in pregnancy: possible therapeutic approach by sex steroid hormones for the treatment of both preeclampsia and preterm labor.
Mizutani et al., Nagoya, Japan. In Exp Clin Endocrinol Diabetes, Mar 2015
Since these hormones are biologically active, the leakage of these hormones into the maternal circulation is regulated by degradation activity by placental aminopeptidases, in order to maintain the balance between carriage of pregnancy and onset of labor.Because the concentration of these hormones, being regulated by the amount of endogenous production and by physiological degradation by enzymes in the blood and tissue, the balance between production and degradation is a definitive element for maintaining normal gestation and term delivery.The changes of the balance between fetal angiotensin II (A-II) and vasopressin (AVP) andA-II and AVP degrading enzymes, between aminopeptidase A (APA) and placental leucine aminopeptidase( P-LAP) - in the placenta and maternal blood due to fetal stress such as hypoxia - are the provable causes of preeclampsia or preterm labor.Induction of APA and P-LAP by estradiol benzoate (E2) and progesterone (P) from placenta has been demonstrated.
Of LAP, CUPS, and DRibbles - Unconventional Use of Autophagy Proteins for MHC Restricted Antigen Presentation.
Münz, Zürich, Switzerland. In Front Immunol, 2014
Macroautophagy delivers cytoplasmic constituents for lysosomal degradation.
Molecular genetics of human primary microcephaly: an overview.
Saleh Jamal et al., In Bmc Med Genomics, 2014
Twelve MCPH loci (MCPH1-MCPH12) have been mapped to date from various populations around the world and contain the following genes: Microcephalin, WDR62, CDK5RAP2, CASC5, ASPM, CENPJ, STIL, CEP135, CEP152, ZNF335, PHC1 and CDK6.
Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes.
Sanjuan et al., Gaithersburg, United States. In Immunity, 2013
Here, we found that in response to DNA-containing immune complexes (DNA-IC), but not to soluble ligands, IFN-α production depended upon the convergence of the phagocytic and autophagic pathways, a process called microtubule-associated protein 1A/1B-light chain 3 (LC3)-associated phagocytosis (LAP).
Tankyrase 1 regulates centrosome function by controlling CPAP stability.
Smith et al., New York City, United States. In Embo Rep, 2012
CPAP degradation and function is controlled by the poly(ADP-ribose) polymerase tankyrase 1.
Reduced alpha-lipoic acid synthase gene expression exacerbates atherosclerosis in diabetic apolipoprotein E-deficient mice.
Maeda et al., Chapel Hill, United States. In Atherosclerosis, 2012
Decreased endogenous lipoic acid gene expression plays a role in development of diabetic atherosclerosis in ApoE deficient mice.
Reduced expression of lipoic acid synthase accelerates diabetic nephropathy.
Maeda et al., Chapel Hill, United States. In J Am Soc Nephrol, 2012
deficiency increases oxidative stress and accelerates the development of diabetic nephropathy
Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation.
Sperl et al., Salzburg, Austria. In Am J Hum Genet, 2012
We identified the homozygous mutation c.746G>A (p.Arg249His) in LIAS in an individual with neonatal-onset epilepsy, muscular hypotonia, lactic acidosis, and elevated glycine concentration in plasma and urine
Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL.
Gönczy et al., Lausanne, Switzerland. In J Cell Sci, 2011
STIL and CPAP are essential for centriole formation and for proper spindle position.
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.
Spiegelman et al., Boston, United States. In Nature, 2009
Here we show that PRDM16 forms a transcriptional complex with the active form of C/EBP-beta (also known as LAP), acting as a critical molecular unit that controls the cell fate switch from myoblastic precursors to brown fat cells.
Loss of nucleoplasmic LAP2alpha-lamin A complexes causes erythroid and epidermal progenitor hyperproliferation.
Foisner et al., Vienna, Austria. In Nat Cell Biol, 2008
Lamina-associated polypeptide (LAP) 2alpha is a chromatin-associated protein that binds A-type lamins.
Mutations in the pericentrin (PCNT) gene cause primordial dwarfism.
Reis et al., Erlangen, Germany. In Science, 2008
Mutations in related genes are known to cause primary microcephaly (MCPH1, CDK5RAP2, ASPM, and CENPJ).
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