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Lysosomal-associated membrane protein 2

LAMP-2, Mac-3, Lysosomal-Associated Membrane Protein 2
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: LAMP-1, ACID, CAN, HAD, LC3
Papers using LAMP-2 antibodies
The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation
Chen Jie et al., In The Journal of Cell Biology, 2010
... anti-FLAG M2 and anti-P18 from Sigma-Aldrich; anti-Myc (9E10.2) and anti-HA (16B12) from Covance; anti-tubulin and anti-LAMP2 from Abcam; anti-V5 from Invitrogen; and ...
Pseudohypoparathyroidism and GNAS epigenetic defects: clinical evaluation of Albright hereditary osteodystrophy and molecular analysis in 40 patients
Friedman Peter A et al., In Journal of Bone and Mineral Research, 2009
... Polyclonal anti-lysosome-associated membrane protein 2 (anti-LAMP-2) was obtained from Anaspec (San Jose, CA, USA) ...
Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells.
Bereswill Stefan, In PLoS ONE, 2001
... Antibodies reactive against EEA1, Rab7, cathepsin D, LAMP1, and LAMP2 were obtained from Abcam.
Ceramide path in human lung cell death
Dennis P A et al., In Cell Death & Disease, 1999
... CD151, CD81, lamp2 and Giα2 antibodies were procured from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
The antiviral, antitumoral xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C
Podo Franca et al., In Breast Cancer Research : BCR, 1995
... Anti-Lamp-2 mAb was supplied by BD Biosciences (San Jose, CA).
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Papers on LAMP-2
Down-Regulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine.
Yue et al., In Mol Pharm, Feb 2016
Enlarged LAMP-2-positive vacuoles with FLAG-OATP1B1 protein retained inside were readily detected in CQ-treated cells, consistent with blocking lysosomal degradation of OATP1B1 by CQ.
The c.65-2A>G splice site mutation is associated with a mild phenotype in Danon disease due to the transcription of normal LAMP2 mRNA.
Zimprich et al., Vienna, Austria. In Clin Genet, Feb 2016
UNASSIGNED: Danon disease (DD) is a rare X-linked multisystem disorder caused by mutations of the LAMP2 gene and characterized by intellectual disability, skeletal myopathy and cardiomyopathy.
Calcium oxalate monohydrate crystals internalized into renal tubular cells are degraded and dissolved by endolysosomes.
Thongboonkerd et al., Bangkok, Thailand. In Chem Biol Interact, Jan 2016
Moreover, markers for early endosome (Rab5), late endosome (Rab7) and lysosome (LAMP-2) were examined by laser-scanning confocal microscopy.
Identification of an oncogenic RAB protein.
Sawyers et al., New York City, United States. In Science, Nov 2015
Furthermore, oncogenic RAB35 is sufficient to drive platelet-derived growth factor receptor α to LAMP2-positive endomembranes in the absence of ligand, suggesting that there may be latent oncogenic potential in dysregulated endomembrane trafficking.
Danon disease: a phenotypic expression of LAMP-2 deficiency.
Nishino et al., Kodaira, Japan. In Acta Neuropathol, Mar 2015
Danon disease is caused by loss-of-function mutations in the LAMP2 gene, which encodes lysosome-associated membrane protein 2 (LAMP-2), a single-spanned transmembrane protein localized in the limiting membranes of lysosomes and late endosomes.
Emerging concepts in the pathogenesis of antineutrophil cytoplasmic antibody-associated vasculitis.
Smith et al., Cambridge, United Kingdom. In Curr Opin Rheumatol, Mar 2015
Anti-lysosomal-associated membrane protein 2 autoantibodies have recently emerged as a novel form of ANCA and can be found in anti-MPO and anti-PR3 negative disease.
Genetic profile of hypertrophic cardiomyopathy in Tunisia: Is it different?
Olivotto et al., Monastir, Tunisia. In Glob Cardiol Sci Pract, 2014
Using the Illumina platform, a panel of 12 genes was analyzed including myosin binding protein C (MYBPC3), beta-myosin heavy chain (MYH7), regulatory and essential light chains (MYL2 and MYL3), troponin-T (TNNT2), troponin-I (TNNI3), troponin-C (TNNC1), alpha-tropomyosin (TPM1), alpha-actin (ACTC1), alpha-actinin-2 (ACTN2) as well as alfa-galactosidase (GLA), 5'-AMP-activated protein (PKRAG2), transthyretin (TTR) and lysosomal-associated membrane protein-2 (LAMP2) for exclusion of phenocopies.
β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.
Cardona-Gómez et al., Medellín, Colombia. In Front Cell Neurosci, 2014
However, the BACE1 RNAi-mediated reduction of hyperphosphorylated tau was only blocked by 3-MA (3-methyladenine) in vitro, and it resulted in the increase of Hsc70 and LAMP2 in lipid rafts from hippocampi of 3xTg-AD mice, and upregulation of survival and homeostasis signaling.
[Neurological involvement in Wegener's granulomatosis].
Muto et al., In Brain Nerve, 2013
In addition, recent studies have revealed another potential antigen for ANCA, lysosomal-associated membrane protein-2 (LAMP-2).
ANCA-associated renal vasculitis - an update.
Hruskova et al., Praha, Czech Republic. In Contrib Nephrol, 2012
Recent discovery of new autoantibodies (anti-LAMP-2) and the role of complement activation in the pathogenesis of AAV could result in better monitoring of the activity of the disease and identification of new treatment targets.
Pathogenesis of rapidly progressive glomerulonephritis: what do we learn?
Chen et al., Shanghai, China. In Contrib Nephrol, 2012
However, the role of LAMP-2 in the disease pathogenesis remains uncertain.
Danon disease caused by two novel mutations of the LAMP2 gene: implications for two ends of the clinical spectrum.
Yuan et al., Beijing, China. In Clin Neuropathol, 2012
findings indicated that patients with Danon disease caused by mutations in exon 1 - 8 manifested as a typically severe phenotype, while patients with mutations in exon 9 of the LAMP2B isoform presented with a relatively benign phenotype
Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury.
Diwan et al., Saint Louis, United States. In Circulation, 2012
Restoration of lysosome-associated membrane protein-2 levels synergizes with partial BECLIN-1 knockdown to restore autophagosome processing and to attenuate cell death after hypoxia-reoxygenation.
Danon disease: a focus on processing of the novel LAMP2 mutation and comments on the beneficial use of peripheral white blood cells in the diagnosis of LAMP2 deficiency.
Sikora et al., Praha, Czech Republic. In Gene, 2012
A novel LAMP2 mutation (c.940delG) in Danon disease patients, which results in a putatively truncated protein.
Altered expression of autophagic genes in the peripheral leukocytes of patients with sporadic Parkinson's disease.
Yan et al., Jining, China. In Brain Res, 2011
decreased LAMP-2 gene expression and increased LC3 gene expression may contribute to the pathogenesis of sporadic Parkinson's disease
LAMP-2 gene expression in peripheral leukocytes is increased in patients with coronary artery disease.
Yan et al., Jining, China. In Clin Cardiol, 2011
Peripheral leukocyte LAMP-2 expression is significantly inceased in coronary artery disease.
Clinical outcome and phenotypic expression in LAMP2 cardiomyopathy.
Seidman et al., Minneapolis, United States. In Jama, 2009
CONTEXT: Mutations in X-linked lysosome-associated membrane protein gene (LAMP2; Danon disease) produce a cardiomyopathy in young patients that clinically mimics severe hypertrophic cardiomyopathy (HCM) due to sarcomere protein mutations.
Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis.
Kerjaschki et al., Vienna, Austria. In Nat Med, 2008
Here we characterize autoantibodies to lysosomal membrane protein-2 (LAMP-2) and show that they are a new ANCA subtype present in almost all individuals with FNGN.
Shared genetic causes of cardiac hypertrophy in children and adults.
Seidman et al., Boston, United States. In N Engl J Med, 2008
We also sequenced PRKAG2 and LAMP2, which encode metabolic proteins; mutations in these genes can cause early-onset ventricular hypertrophy.
Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J.
Meisler et al., Ann Arbor, United States. In Nature, 2007
The cytoplasm of fibroblasts from pale tremor mice is filled with large vacuoles that are immunoreactive for LAMP-2 (lysosomal-associated membrane protein 2), consistent with dysfunction of the late endosome-lysosome axis.
More papers using LAMP-2 antibodies
In vivo skin penetration studies of camomile flavones
Koul Hari, In PLoS ONE, 1993
... We purchased the Parp and p62 antibody from BD Biosciences, anti-LAMP-2 antibody from Abcam (Cambridge, UK) and the ...
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