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Lamin B1

lamin B, lamin B1
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: CAN, PrP, ACID, POLYMERASE, HAD
Papers using lamin B antibodies
Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer
Chen Wei et al., In Breast Cancer Research : BCR, 2009
... Lamin B1 rabbit antibody was from Abcam (Cambridge, MA, USA) ...
Uncaria rhynchophylla induces heme oxygenase-1 as a cytoprotective effect in RAW 264.7 macrophages.
Pal Soumitro, In PLoS ONE, 2009
... The following antibodies were used; anti-Nrf2 (Santa Cruz Biotechnology, Santa Cruz, CA), anti-Lamin B (Santa Cruz), anti-HO-1 (Epitomics, Burlingame, CA), anti-phospho-p38 (Cell ...
Isolation of intact nuclei of high purity from mouse liver.
Bridger Joanna Mary, In PLoS ONE, 2009
... experiments we used affinity purified antibody directed to the NM1 N-terminus M3567 (Sigma), antibodies to lamin B (M-20, Santa Cruz Biotechnology), V5-tag (Serotec), V5-tag (V8137-Sigma), ...
Radioprotective effects of hesperidin against genotoxicity induced by γ-irradiation in human lymphocytes
Kim Jung-Ae et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2008
... B (p65) and lamin B were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signaling.
Thi Thu Nguyen Hang, In PLoS ONE, 2008
... Antibodies to actin, tubulin, and lamin B were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
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Papers on lamin B
Delivering Single-Walled Carbon Nanotubes to the Nucleus Using Engineered Nuclear Protein Domains.
Dahl et al., In Acs Appl Mater Interfaces, Feb 2016
Here we report delivery of SWCNTs to the nucleus by non-covalently attaching the tail domain of the nuclear protein lamin B1 (LB1), which we engineer from the full-length LMNB1 cDNA.
A switch in Akt isoforms is required for Notch-induced Snail1 expression and protection from cell death.
Díaz et al., Barcelona, Spain. In Mol Cell Biol, Jan 2016
Akt2, but not Akt1, co-localizes in the nucleus with lamin B in the nuclear envelope.
Nuclear Architecture Organized by Rif1 Underpins the Replication-Timing Program.
Buonomo et al., Monterotondo, Italy. In Mol Cell, Jan 2016
Here we show that in mouse embryonic stem cells, Rif1 coats late-replicating domains and, with Lamin B1, identifies most of the late-replicating genome.
Knocking down Dp71 expression in A549 cells reduces its malignancy in vivo and in vitro.
Zhang et al., Changsha, China. In Cancer Invest, Jan 2016
The A549-Dp71AS cells and xenograft tumor tissues displayed reduced lamin B1, Bcl-2, and MMP2 protein expression, which accounts for the reduced malignancy of A549-Dp71AS cells in vivo and in vitro.
Autophagy mediates degradation of nuclear lamina.
Berger et al., Philadelphia, United States. In Nature, Dec 2015
The autophagy protein LC3/Atg8, which is involved in autophagy membrane trafficking and substrate delivery, is present in the nucleus and directly interacts with the nuclear lamina protein lamin B1, and binds to lamin-associated domains on chromatin.
Nuclear lamina remodelling and its implications for human disease.
Dreesen et al., Singapore, Singapore. In Cell Tissue Res, Jun 2015
In addition, elevated levels of lamin B1, attributable to genomic duplications of the LMNB1 locus, cause adult-onset autosomal dominant leukodystrophy.
Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum.
Blobel et al., New York City, United States. In Nature, 2015
Lamin B receptor (LBR), an integral inner nuclear membrane protein, also contains a functional C14SR domain.
The role of lamin B1 for the maintenance of nuclear structure and function.
Ried et al., Barcelona, Spain. In Nucleus, 2014
By 3D-FISH, Camps and colleagues showed that lamin B1 (LMNB1) is required for proper chromosome condensation in interphase nuclei, and deficiency of LMNB1 triggers the relocation of the epigenetic mark of facultative heterochromatin, H3K27me3, toward the interior of the nucleus.
Chromatin maintenance and dynamics in senescence: a spotlight on SAHF formation and the epigenome of senescent cells.
Stucki et al., Zürich, Switzerland. In Chromosoma, 2014
Here, we summarize and review recent findings shedding light on SAHF composition and formation via spatial repositioning of chromatin, with a specific focus on the role of lamin B1 for this process.
Nuclear lamins and neurobiology.
Fong et al., Los Angeles, United States. In Mol Cell Biol, 2014
Also, duplications of LMNB1 (the gene for lamin B1) have been shown to cause autosome-dominant leukodystrophy.
Update on several/certain adult-onset genetic leukoencephalopathies: clinical signs and molecular confirmation.
Federico et al., Siena, Italy. In J Alzheimers Dis, 2013
In particular, we review the clinical spectrum and the molecular pathogenesis of certain adult-onset leukoencephalopathies, including cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL), cerebroretinal microangiopathy with calcifications and cysts (CRMCC), hereditary diffuse leukoencephalopathy with spheroids (HDLS), fragile X-associated tremor/ataxia syndrome (FXTAS), vanishing white matter disease (VWM), autosomal dominant leukodystrophy due to lamin B1 duplication (ADLD), and vascular leukoencephalopathy mapping to chromosome 20q13.
LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation.
Joffe et al., Martinsried, Germany. In Cell, 2013
To investigate mechanisms regulating chromatin distribution, we analyzed heterochromatin organization in different tissues and species, including mice with mutations in the lamin B receptor (Lbr) and lamin A (Lmna) genes that encode nuclear envelope (NE) proteins.
Mechanisms involved in curcumin-induced human neutrophil apoptosis: Evidence that curcumin activates the endoplasmic reticulum stress-induced cell apoptosis pathway.
Girard et al., Québec, Canada. In Sage Open Med, 2012
Curcumin activated caspase-3 and the cleavage of the two cytoskeletal proteins lamin B1 and vimentin.
DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina.
Singh et al., Chicago, United States. In Cell, 2012
Lamina interaction is established during mitosis and likely involves the localized recruitment of Lamin B during late anaphase.
Lamin B1 loss is a senescence-associated biomarker.
Campisi et al., Berkeley, United States. In Mol Biol Cell, 2012
Lamin B1 is lost from primary human and murine cell strains when they are induced to senesce.
Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation.
Bertrand et al., Fontenay-aux-Roses, France. In Embo J, 2012
The authors show that oxidative stress increases lamin B1 levels through p38 Mitogen Activated Protein kinase activation.
Adult-onset autosomal dominant leukodystrophy due to LMNB1 gene duplication.
Grau et al., In J Neurol, 2012
This study demonistrated that Adult-onset autosomal dominant leukodystrophy due to LMNB1 gene duplication.
Crystal structures of the coil 2B fragment and the globular tail domain of human lamin B1.
Zang et al., Hefei, China. In Febs Lett, 2012
crystal structures of lamin B1 globular tail domain and coiled 2B domain, with similar folds to Ig-like domain and coiled-coil domain of lamin A. Found an extra intermolecular disulfide bond in lamin B1 coil 2B domain, which does not exist in lamin A/C.
Local translation of extranuclear lamin B promotes axon maintenance.
Holt et al., Cambridge, United Kingdom. In Cell, 2012
Our results thus suggest that axonally synthesized lamin B plays a crucial role in axon maintenance by promoting mitochondrial function.
The role of nuclear lamin B1 in cell proliferation and senescence.
Goldman et al., Chicago, United States. In Genes Dev, 2012
LB1 expression in WI-38 cells decreases during cellular senescence
More papers using lamin B antibodies
Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammation
Tian Ke-Li et al., In The Indian Journal of Medical Research, 2008
... Rat anti-PPARγ, anti-NF-κB-p65, anti-β-actin and anti-lamin B antibodies were purchased from Santa Cruz Biotechnology (USA), and Goat anti-mouse ...
The epithelial-mesenchymal transition generates cells with properties of stem cells
Orsulic Sandra, In PLoS ONE, 2007
... anti-β-catenin, anti-N-cadherin and anti-β-actin-horseradish peroxidase (HRP) mAb were from Santa Cruz Biotechnologies (Santa Cruz, CA), anti-lamin B1 was from Abcam (Cambridge, UK) ...
Interstitial leukocyte migration and immune function
Griffiths Gillian M et al., In European Journal of Immunology, 2007
... Primary antibodies used for immunofluorescence were: rabbit anti-γ-tubulin (Sigma-Aldrich), anti-lamin B1 (Abcam), and anti-actin (Sigma-Aldrich); mouse ...
The blood-brain barrier in health and chronic neurodegenerative disorders
Brito Maria A. et al., In Frontiers in Cellular Neuroscience, 2007
... Rabbit anti-lamin B1 was from Abcam (Cambridge, UK) ...
Nuclear and cytoplasmic mRNA quantification by SYBR green based real-time RT-PCR.
Digard Paul, In PLoS ONE, 2005
... Anti-β-actin (sc-1616-R), anti-lamin B1 was purchased from Santa Cruz Biotechnology and anti-α-tubulin was purchased ...
p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation
Tsukita Sachiko et al., In The Journal of Cell Biology, 2005
... Mouse anti-HA mAb (Covance), goat anti–ZO-2 pAb, rabbit anti-Trio pAb, rabbit anti-Tbx3 pAb, anti–lamin B pAb (Santa Cruz Biotechnology, Inc.), anti-p38, anti–phospho p38 ...
Novel role of the muskelin–RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation
Adams Josephine C. et al., In The Journal of Cell Biology, 2002
... Goat anti–lamin B1 antibody was obtained from Santa Cruz Biotechnology, Inc ...
Nuclear localization of EGF receptor and its potential new role as a transcription factor
Gottardi Cara, In PLoS ONE, 2000
... Antibodies against GAPDH (6C5; sc-32233), Sp1 (sc-59), lamin B1 (sc-20682), and U1snRNP70 (sc-25371) were obtained from Santa Cruz Biotechnology (Santa Cruz CA) ...
Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells.
Zheng Song Guo, In PLoS ONE, 1999
... Anti-Lamin B (ab-16048) was purchased from Abcam.
Caspase-dependent and -independent death of camptothecin-treated embryonic cortical neurons.
LeBlanc Andrea C., In PLoS ONE, 1998
... Pure lamin A protein and lamin B1 antibody were from Abcam (cat ...
Saccharomyces cerevisiae homologs of mammalian B and B′ subunits of protein phosphatase 2A direct the enzyme to distinct cellular functions
Warren Graham et al., In The Journal of Cell Biology, 1996
... Mouse monoclonal anti-vimentin and goat polyclonal anti–lamin B antibodies were purchased from Santa Cruz Biotechnology.
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death
Tohyama Masaya et al., In The Journal of Cell Biology, 1996
... (4B9; MBL International Corporation), anti–caspase-4 pAb (Santa Cruz Biotechnology, Inc.), anti-KDEL mAb (10C3; StressGen Biotechnologies), anti–Lamin B1 mAb (L-5; Zymed Laboratories), anti–cytochrome c mAb (7H8.2C12;
Gene structure and chromosomal localization of the murine lamin B2 gene
Goldman Robert D. et al., In The Journal of Cell Biology, 1990
... In addition, lamin B1 was cloned into the cyan version of GFP (pECFP-C1; CLONTECH Laboratories, Inc.), and lamin ...
Site-directed mutagenesis by overlap extension using the polymerase chain reaction
Kim D-G et al., In Cell Death & Disease, 1988
... CA, USA), the goat polyclonal antibodies against human H2A (C-19), human nucleosporin p62 (D-20) and lamin B (C-20), and rabbit polyclonal antibodies against human PARP, H-250 and against human Ub (FL-76) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation
Vaux David J. et al., In The Journal of Cell Biology, 1987
... Goat anti–lamin B1 antibody (model C20; Santa Cruz Biotechnology, Inc.) was characterized by ...
Quantitation of pyrimidine dimers by immunoslot blot following sublethal UV-irradiation of human cells.
Bielinsky Anja-Katrin, In PLoS ONE, 1986
... Rabbit anti-XPB (S-19), anti-XPD (H-150), anti-MAT1 (FL-309), monoclonal anti-p62 (G-10), anti-Cdk7 (C-4) and goat polyclonal anti-Lamin B antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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