Interspecies Complementation of the LuxR Family Pathway-Specific Regulator Involved in Macrolide Biosynthesis.
South Korea. In J Microbiol Biotechnol, Dec 2015
UNASSIGNED: PikD is a widely known pathway-specific regulator for controlling pikromycin production in Streptomyces venezuelae ATCC 15439, which is a representative of the large ATP-binding regulator of the LuxR family (LAL) in Streptomyces sp.. RapH and FkbN also belong to the LAL family of transcriptional regulators, which show greatest homology with the ATP-binding motif and helix-turn-helix DNA-binding motif of PikD.
Sebelipase Alfa: First Global Approval.
Auckland, New Zealand. In Drugs, Nov 2015
Sebelipase alfa (Kanuma™) is a recombinant human lysosomal acid lipase (LAL) developed by Synageva BioPharma Corp. (now Alexion Pharmaceuticals, Inc.) for long-term enzyme replacement therapy in patients with LAL deficiency.
Rare Genetic Disorders Altering Lipoproteins
Madagascar. In Unknown Journal, Jul 2015
The aim of this chapter is to examine other, less common genetic disorders including elevations of lipoprotein(a); disorders of high density lipoprotein (familial hypoalphalipoproteinemia, Tangier disease, and LCAT deficiency); familial hypocholesterolemias (familial hypobetalipoproteinemia, abetalipoproteinemia, PCSK9 loss of function mutations, familial combined hypolipidemia, and chylomicron retention disease); ß-sitosterolemia; cerebrotendinous xanthomatosis, and lysosomal acid lipase deficiency.
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.
Saint Louis, United States. In Nat Immunol, 2014
We found that the uptake of triacylglycerol substrates via the scavenger receptor CD36 and their subsequent lipolysis by lysosomal acid lipase (LAL) was important for the engagement of elevated oxidative phosphorylation, enhanced spare respiratory capacity (SRC), prolonged survival and expression of genes that together define M2 activation.