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Glyoxalase I

Lactoylglutathione Lyase, glyoxalase I, glyoxalase, GLO1
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, AGE, V1a, HAD
Papers using Lactoylglutathione Lyase antibodies
Receptor for advanced glycation end products and its ligands: a journey from the complications of diabetes to its pathogenesis
Ushio-Fukai Masuko, In PLoS ONE, 2004
... peroxidase conjugated secondary antibodies (Cell Signaling, Danvers, MA); VEGFR2 (Flk-1:A-3), Bcl-2, Bax, Caspase 3, and Glo1 (Santa Cruz Biotechnology, Santa Cruz, CA); SOD2 ...
Papers on Lactoylglutathione Lyase
Glyoxalase I drives epithelial-to-mesenchymal transition via argpyrimidine-modified Hsp70, miR-21 and SMAD signalling in human bronchial cells BEAS-2B chronically exposed to crystalline silica Min-U-Sil 5: transformation into a neoplastic-like phenotype.
Talesa et al., Perugia, Italy. In Free Radic Biol Med, Feb 2016
UNASSIGNED: Glyoxalase I (Glo1) is the main scavenging enzyme of methylglyoxal (MG), a potent precursor of advanced glycation endproducts (AGEs).
The DJ-1 superfamily members YhbO and YajL from Escherichia coli repair proteins from glycation by methylglyoxal and glyoxal.
Richarme et al., Paris, France. In Biochem Biophys Res Commun, Feb 2016
Finally, the apparent glyoxalase activities of YhbO and YajL reflect their deglycase activities.
Carbonyl stress phenomena during chronic infection with Opisthorchis felineus.
Sazonov et al., Tomsk, Russia. In Parasitol Int, Feb 2016
Expression of mRNA encoding glyoxalase 1 decreased at 8weeks of the infection and catalytic activity as well decreased at 8 and 12weeks after infection, and the expression of the glyoxalase 2 decreased until 36week post infection, which associated with the decreasing activity of the enzyme at 8, 12week post infection.
Promiscuous metallo-β-lactamases: MIM-1 and MIM-2 may play an essential role in quorum sensing networks.
Mitić et al., Ireland. In J Inorg Biochem, Jan 2016
Although both sequence comparison and homology modeling indicate that these proteins are homologous to well-known MBLs such as AIM-1, the sequence analysis also indicated that MIM-1 and MIM-2 share similarities with N-acyl homoserine lactonases (AHLases) and glyoxalase II (GLX-II).
Glyoxalase biochemistry.
Honek, In Biomol Concepts, Jan 2016
The glyoxalase enzyme system utilizes intracellular thiols such as glutathione to convert α-ketoaldehydes, such as methylglyoxal, into D-hydroxyacids.
In Vitro Inhibition of Glyoxalase І by Flavonoids: New Insights from Crystallographic Analysis.
Hu et al., Guangzhou, China. In Curr Top Med Chem, Dec 2015
The antitumor pharmacological property of flavonoids is correlated with inhibition towards glyoxalase I (GLOI), a critical zinc-enzyme in the methylglyoxal detoxification pathway.
Expression of the Receptor for Advanced Glycation End Products in Epicardial Fat: Link with Tissue Thickness and Local Insulin Resistance in Coronary Artery Disease.
Corsi Romanelli et al., Milano, Italy. In J Diabetes Res, Dec 2015
EAT expression of RAGE, GLUT4, adiponenctin, GLO1, HMGB1, TLR-4, and MyD88 was analyzed by microarray.
The C. elegans dauer larva as a paradigm to study metabolic suppression and desiccation tolerance.
Kurzchalia et al., Dresden, Germany. In Planta, Aug 2015
These are increased glyoxalase activity, polyamine and polyunsaturated fatty acid biosynthesis.
The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases.
Schalkwijk et al., Maastricht, Netherlands. In Clin Sci (lond), Jun 2015
Under physiological circumstances, MGO is detoxified by the glyoxalase system into D-lactate, with glyoxalase I (GLO1) as the key enzyme in the anti-glycation defence.
Methylglyoxal, the dark side of glycolysis.
Magistretti et al., Lausanne, Switzerland. In Front Neurosci, 2014
In normal situations, cells are protected against methylglyoxal toxicity by different mechanisms and in particular the glyoxalase system, which represents the most important pathway for the detoxification of methylglyoxal.
Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade.
López-Camarillo et al., Mexico. In Int J Oncol, 2012
GLO1 is overexpressed in 79 percent of tumors and GLO1 up-regulation correlates with advanced tumor grade.
Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal.
Palmer et al., Chicago, United States. In J Clin Invest, 2012
pharmacological inhibition of GLO1 reduced anxiety, suggesting that GLO1 is a possible target for the treatment of anxiety disorders.
Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation.
Thornalley et al., Coventry, United Kingdom. In Biochem J, 2012
We conclude that dicarbonyl stress is countered by up-regulation of Glo1 in the Nrf2 stress-responsive system.
Increased glyoxalase I levels inhibit accumulation of oxidative stress and an advanced glycation end product in mouse mesangial cells cultured in high glucose.
Kim et al., Taejŏn, South Korea. In Exp Cell Res, 2012
These results suggest that GLO-1 plays a role in high glucose-mediated signaling by reducing mesangial cells accumulation and oxidative stress in diabetes mellitus.
Glyoxalase-I is a novel prognosis factor associated with gastric cancer progression.
Lin et al., Taiwan. In Plos One, 2011
GLO1 expression was higher in gastric cancer tissues, compared with that in adjacent noncancerous tissues.
Design and evolution of new catalytic activity with an existing protein scaffold.
Kim et al., Taejŏn, South Korea. In Science, 2006
Using this approach, we were able to introduce beta-lactamase activity into the alphabeta/betaalpha metallohydrolase scaffold of glyoxalase II.
Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice.
Barlow et al., Los Angeles, United States. In Nature, 2006
Local overexpression in the mouse brain resulted in increased anxiety-like behaviour; Glo1 is involved in oxidative stress metabolism, linking this pathway with anxiety-related behaviour
Major-histocompatibility-complex extended haplotypes in membranoproliferative glomerulonephritis.
West et al., In N Engl J Med, 1986
The extended haplotype HLA-B8,DR3,SC01,GLO2(glyoxalase I 2) was observed in 9 of 68 disease-associated haplotypes (13 percent), but in only 3 of 205 controls (1 percent) (relative risk, 14.79; P less than 0.001).
Extended MHC haplotypes in 21-hydroxylase-deficiency congenital adrenal hyperplasia: shared genotypes in unrelated patients.
Alper et al., In Lancet, 1983
The haplotype containing this rare set of complement alleles always carried the rare HLA allele, HLA-Bw47, usually carried HLA-A3, and almost always had the alleles HLA-Cw6, HLA-DR7, and the glyoxalase I (GLO) allele GLO1.
Close genetic linkage between diabetes mellitus and kidd blood group.
Rotter et al., In Lancet, 1981
Under three different genetic models for IDDM, evidence was found for linkage between the disease and two distinct sets of marker loci: three markers on chromosome 6 (HLA, properdin factor B, and glyoxalase-1), and the Kidd blood group locus.
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