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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


Lac, lactase
The protein encoded by this gene belongs to the family 1 of glycosyl hydrolases. The protein is integral to plasma membrane and has both phlorizin hydrolase activity and lactase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, Sucrase, ACID
Papers using Lac antibodies
Antiviral effect of N-butyldeoxynojirimycin against bovine viral diarrhea virus correlates with misfolding of E2 envelope proteins and impairment of their association into E1–E2 heterodimers.
Ryu Wang-Shick, In PLoS ONE, 2000
... Lactacystine (Lac) was from Toronto Chemicals, MG132 was from Santa Cruz, Tunicamicin (Tu) was from MP Biomedicals, 3-methyladenine (3MA) and chloroquine ...
Papers on Lac
Effect of Polysaccharides from Acanthopanax senticosus on Intestinal Mucosal Barrier of Escherichia coli Lipopolysaccharide Challenged Mice.
Bian et al., Jinzhou, China. In Asian-australas J Anim Sci, Jan 2016
The results showed that ASPS ameliorated LPS-induced deterioration of digestive ability of LPS-challenged mice, indicated by an increase in intestinal lactase activity (45%, p<0.05), and the intestinal morphology, as proved by improved villus height (20.84%, p<0.05) and villus height:crypt depth ratio (42%, p<0.05), and lower crypt depth in jejunum (15.55%, p<0.05), as well as enhanced intestinal tight junction proteins expression involving occludin-1 (71.43%, p<0.05).
Regulation of neuron-astrocyte metabolic coupling across the sleep-wake cycle.
Magistretti et al., Switzerland. In Neuroscience, Jan 2016
However, the recent development of substrate-specific biosensors allowed measurements of the variation in extracellular levels of glutamate, Gluc and lactate (Lac) with a time resolution compatible with sleep stage duration.
Genetic diversity of lactase persistence in East African populations.
Netea et al., Manama, Bahrain. In Bmc Res Notes, Dec 2015
BACKGROUND: The expression of lactase which digests lactose from milk in humans is generally lost after weaning, but selected mutations influencing the promoter of the lactase gene have spread into the human populations.
Lactose nutrition in lactase nonpersisters.
Wahlqvist, Melbourne, Australia. In Asia Pac J Clin Nutr, Dec 2015
Abstract available from the publisher.
[Lactose intolerance: past and present. Part II].
Buzás, Budapest, Hungary. In Orv Hetil, Nov 2015
Lactase gene genotype and fracture risk are related in some populations.
[Lactose intolerance: past and present. Part 1].
Buzás, Budapest, Hungary. In Orv Hetil, Oct 2015
After presentation of its history, the author describes the emergence of lactose intolerance during the evolution of species, and the biochemistry of lactose as well as features of human and bacterial lactase enzymes are then described.
Lactose Intolerance in Adults: Biological Mechanism and Dietary Management.
Fox et al., Hangzhou, China. In Nutrients, Sep 2015
Lactose intolerance related to primary or secondary lactase deficiency is characterized by abdominal pain and distension, borborygmi, flatus, and diarrhea induced by lactose in dairy products.
A quantitative understanding of lac repressor's binding specificity and flexibility.
Stormo et al., Saint Louis, United States. In Quant Biol, Jul 2015
UNASSIGNED: Lac repressor, the first discovered transcriptional regulator, has been shown to confer multiple-modes of binding to its operator sites depending on the central spacer length.
Identification of Coccoidal Bacteria in Traditional Fermented Milk Products from Mongolia, and the Fermentation Properties of the Predominant Species, Streptococcus thermophilus.
Zhang et al., Hohhot, China. In Korean J Food Sci Anim Resour, 2014
These coccoid isolates were distributed in four genera and six species: Enterococcus (E.) durans, Enterococcus (E.) faecalis, Lactococcus (Lac.)
An in vivo model of human small intestine using pluripotent stem cells.
Helmrath et al., Cincinnati, United States. In Nat Med, 2014
In vivo transplantation resulted in marked expansion and maturation of the epithelium and mesenchyme, as demonstrated by differentiated intestinal cell lineages (enterocytes, goblet cells, Paneth cells, tuft cells and enteroendocrine cells), presence of functional brush-border enzymes (lactase, sucrase-isomaltase and dipeptidyl peptidase 4) and visible subepithelial and smooth muscle layers when compared with HIOs in vitro.
Single-nucleotide polymorphism in Turkish patients with adolescent idiopathic scoliosis: curve progression is not related with MATN-1, LCT C/T-13910, and VDR BsmI.
Ozdemir et al., Çanakkale, Turkey. In J Orthop Res, 2012
no significant difference in single nucleotide polymorphism between adolescent idiopathic scoliosis cases and controls
First dairying in green Saharan Africa in the fifth millennium BC.
di Lernia et al., Bristol, United Kingdom. In Nature, 2012
These findings confirm the importance of 'lifetime products', such as milk, in early Saharan pastoralism, and provide an evolutionary context for the emergence of lactase persistence in Africa.
Herders of Indian and European cattle share their predominant allele for lactase persistence.
Kivisild et al., Cambridge, United Kingdom. In Mol Biol Evol, 2012
We confirm that the 13910 C>T mutation seen in DNA samples from across the Indian subcontinent, is identical by descent to the European allele and is associated with the same>1 Mb extended haplotype in both European and Indian populations.
Deep human genealogies reveal a selective advantage to be on an expanding wave front.
Excoffier et al., Montréal, Canada. In Science, 2011
We find that a majority of the present Saguenay Lac-Saint-Jean population can be traced back to ancestors having lived directly on or close to the wave front.
Heterochromatin boundaries are hotspots for de novo kinetochore formation.
Heun et al., Freiburg, Germany. In Nat Cell Biol, 2011
Although overexpression of heterochromatin protein 1 (HP1) or increasing histone acetylation interferes with CID island formation on a global scale, induction of a locally defined region of synthetic heterochromatin by targeting HP1-LacI fusions to stably integrated Lac operator arrays produces a proximal hotspot for CID deposition.
Comparison of lactase persistence polymorphism in ancient and present-day Hungarian populations.
Raskó et al., Szeged, Hungary. In Am J Phys Anthropol, 2011
The aim of this study was to determine the prevalence of lactase persistent and non-persistent genotypes in current Hungarian-speaking populations and in ancient Carpathian basin human bone samples.
Theodore E. Woodward Award: lactase persistence SNPs in African populations regulate promoter activity in intestinal cell culture.
Ahn et al., Stanford, United States. In Trans Am Clin Climatol Assoc, 2010
Report lactase persistence SNPs in African populations regulate promoter activity in Caco-2 cells.
Molecular Characterization and In Vitro Analyses of a Sporogenous Bacterium with Potential Probiotic Properties.
Ghosh et al., Kharagpur, India. In Probiotics Antimicrob Proteins, 2010
In addition to these characteristics, the bacterium also produced enzymes such as amylase, cellulase, lipase, protease, lactase and catalase, which can help in improving digestion and overall health, alleviate lactose intolerance and remove oxidative stresses, required for the well-being of the consumers.
LCT-22018G>A single nucleotide polymorphism is a better predictor of adult-type hypolactasia/lactase persistence in Japanese-Brazilians than LCT-13910C>T.
Carrilho et al., São Paulo, Brazil. In Clinics (sao Paulo), 2009
The LCT-22018G>A allele is a better predictor of lactase persistence in Japanese-Brazilians than the LCT-13910C>T allele.
Convergent adaptation of human lactase persistence in Africa and Europe.
Deloukas et al., College Park, United States. In Nat Genet, 2007
Three SNPs (G/C-14010, T/G-13915 and C/G-13907) are associated with lactase persistence in African groups.
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