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RPL39 Rpl39p

L46, RPL39, SPB2, ribosomal protein L39, RPL46, YL40
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the S39E family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein is the smallest, and one of the most basic, proteins of the ribosome. This gene is co-transcribed with the U69 small nucleolar RNA gene, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, OUT, poly(A)-binding protein
Papers on L46
A case of thyroid hormone resistance: a rare mutation.
Mascarenhas et al., Lisbon, Portugal. In Arq Bras Endocrinol Metabol, 2014
Mutations interfering with three major steps required for TH action on target tissues have been, so far, identified (TR-β, TR-α, MCT8, SPB2).
Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling.
Chang et al., Shanghai, China. In Proc Natl Acad Sci U S A, 2014
Selective shRNA knockdown identified ribosomal protein L39 (RPL39) and myeloid leukemia factor 2 (MLF2) as the top candidates that affect BCSC self-renewal.
Knockdown of ribosomal protein L39 by RNA interference inhibits the growth of human pancreatic cancer cells in vitro and in vivo.
Zhu et al., Shanghai, China. In Biotechnol J, 2014
Our previous studies showed that the ribosomal protein L39 (RPL39) gene was up-regulated after long-term silencing of oncogenic KRAS in pancreatic cancer PANC-1 cells, which indicated that RPL39 may be important for pancreatic cancer development and survival.
Effects of ribosomal protein l39-L on the drug resistance mechanisms of lung cancer A549 cells.
Zhu et al., Jining, China. In Asian Pac J Cancer Prev, 2013
As a component of the 60S large ribosomal subunit, ribosomal protein L39-L gene was reported to be expressed specifically in the human testis and human cancer samples of various tissue origins.
Influence of ribosomal protein L39-L in the drug resistance mechanisms of lacrimal gland adenoid cystic carcinoma cells.
Tan et al., Jining, China. In Asian Pac J Cancer Prev, 2013
As an element of the 60S large ribosomal subunit, the ribosomal protein L39-L gene appears to be documented specifically in the human testis and many human cancer samples of different origins.
Interaction of nascent chains with the ribosomal tunnel proteins Rpl4, Rpl17, and Rpl39 of Saccharomyces cerevisiae.
Rospert et al., Freiburg, Germany. In J Biol Chem, 2013
Three ribosomal proteins, termed Rpl4, Rpl17, and Rpl39 expose domains to the interior of the exit tunnel of eukaryotic ribosomes.
Nitrogen starvation, salt and heat stress in coffee (Coffea arabica L.): identification and validation of new genes for qPCR normalization.
Domingues et al., Londrina, Brazil. In Mol Biotechnol, 2013
EF1, EF1α, GAPDH, MDH, and UBQ10 were ranked as the most stable genes in all stresses and software analyses, while RPL39 and RPII were classified as the less reliable references.
Detection of drug-induced conformational change of a transmembrane protein in lipid bilayers using site-directed spin labeling.
Howard et al., United States. In Protein Sci, 2013
M2TMC peptides were spin labeled site specifically at cysteine residues substituted for amino acids within the transmembrane domain (L36, I39, I42, and L43) and the C-terminal amphipathic helix (L46, F47, F48, C50, I51, Y52, R53, F54, F55, and E56).
Torque values of antagonistic muscles of the hipjoint. Pilot study.
Mroczek et al., Zamość, Poland. In Ortop Traumatol Rehabil, 2012
The tests were carried out in the Zamość Rehabilitation Department of CMPA in an SPB2-FM unit.
Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia.
Beggs et al., Boston, United States. In Hum Mutat, 2012
We completed a large-scale screen of 79 RP genes by sequencing 16 RP genes (RPL3, RPL7, RPL8, RPL10, RPL14, RPL17, RPL19, RPL23A, RPL26, RPL27, RPL35, RPL36A, RPL39, RPS4X, RPS4Y1, and RPS21) in 96 DBA probands.
Evidence that Yih1 resides in a complex with ribosomes.
Sattlegger et al., Auckland, New Zealand. In Febs J, 2012
Furthermore, GST-Yih1 coprecipitated large ribosomal protein Rpl39 independently of Gcn1.
Gene expression profiling in peripheral blood cells of patients with rheumatoid arthritis in response to anti-TNF-alpha treatments.
Fabien et al., Lyon, France. In Physiol Genomics, 2011
Importantly, the expression of several genes, including those coding for the calcium binding proteins S100A12 and A8, CD14 antigen, Selectin P, or ribosomal protein L39, reported to be upregulated in RA patients, were found to be decreased after anti-TNF-α treatment.
Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population.
Duga et al., Milano, Italy. In J Lipid Res, 2010
A trend toward a protective effect of the L46 allele was observed [odds ratio (OR) = 0.75, 95% confidence interval (CI) = 0.49-1.13;
Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46.
Davis et al., Stanford, United States. In Science, 1990
The aberrant production of 25S ribosomal RNA (rRNA) occurring in spb4-1 mutants or the deletion of SPB2 (RPL46) permits the deletion of PAB1.
The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation.
Davis et al., Stanford, United States. In Cell, 1989
Consistent with this, SPB2 encodes the ribosomal protein L46.
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