The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm
In Biologics : Targets & Therapy, 2003
... , fluorescein conjugates, Caltag, San Francisco, CA), CD15 (IgM, phycoerythrin-conjugate), CD45, CD62L (IgG1, fluorescein-conjugates, Becton Dickinson, San Jose, CA), Lewis ...
Nasal vaccination stimulates CD8(+) T cells for potent protection against mucosal Brucella melitensis challenge.
Gainesville, United States. In Immunol Cell Biol, Feb 2016
Evaluation of pulmonary and splenic CD8(+) T cells from mice vaccinated with ΔznuA B. melitensis revealed that these expressed an activated effector memory (CD44(hi)CD62L(lo)CCR7(lo)) T cells producing elevated levels of IFN-γ, TNF-α, perforin, and granzyme B. To assess the relative importance of these increased numbers of CD8(+) T cells, CD8(-/-) mice were challenged with virulent B. melitensis, and they showed markedly increased bacterial loads in organs in contrast to similarly challenged CD4(-/-) mice.
CD62L is not a reliable biomarker for predicting PML risk in natalizumab-treated R-MS patients.
Cambridge, United States. In Neurology, Jan 2016
OBJECTIVE: To assess if the percentage of CD3(+)CD4(+)CD62L(+) cells in cryopreserved peripheral blood mononuclear cells (PBMCs) (here termed %CD62L) can predict risk of developing progressive multifocal leukoencephalopathy (PML) and better inform the physician for benefit-risk assessment of natalizumab treatment decisions in a global setting.
Memory T cells officially join the stem cell club.
Bethesda, United States. In Immunity, 2014
(2014) demonstrate self-renewal and multipotency of a single CD62L(+) memory T cell across serial adoptive transfers and infection-driven re-expansions, providing evidence of true stemness within the T cell memory compartment.
[Selectins as adhesion molecules and potential therapeutic target].
Tunisia. In Arch Inst Pasteur Tunis, 2010
There are three types of selectin: the L-selectin (CD62L), which is constitutively expressed by most leukocyte populations, the P-selectin (CD62P) is found on activated platelets and endothelial cells, and the E-selectin (CD62E) expressed by activated endothelial cells.