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Transmembrane 4 L six family member 1

L-6, Nut2, tumor-associated antigen L6, TM4SF1, Med10
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: POLYMERASE, CAN, Med7, HAD, V1a
Papers on L-6
Role of the short isoform of the progesterone receptor in breast cancer cell invasiveness at estrogen and progesterone levels in the pre- and post-menopausal ranges.
Ratnam et al., Detroit, United States. In Oncotarget, Nov 2015
Among estrogen-regulated genes, progestin/PR-A counter-regulated a distinctive subset, including breast tumor progression genes (e.g., HES1, PRKCH, ELF5, TM4SF1), leading to invasiveness.
Intracellular distribution of TM4SF1 and internalization of TM4SF1-antibody complex in vascular endothelial cells.
Jaminet et al., United States. In Biochem Biophys Res Commun, Oct 2015
Transmembrane-4 L-six family member-1 (TM4SF1) is a small plasma membrane-associated glycoprotein that is highly and selectively expressed on the plasma membranes of tumor cells, cultured endothelial cells, and, in vivo, on tumor-associated endothelium.
TM4SF1 as a prognostic marker of pancreatic ductal adenocarcinoma is involved in migration and invasion of cancer cells.
Tanaka et al., Fukuoka, Japan. In Int J Oncol, Aug 2015
The cell surface protein Transmembrane 4 L6 family member 1 (TM4SF1) has been detected in various tumors, and its expression on tumor cells is implicated in cancer cell metastasis and patient prognosis.
Novel Anti-TM4SF1 Antibody-Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature.
Jaminet et al., Boston, United States. In Mol Cancer Ther, Aug 2015
Here, we report a novel humanized ADC that targets the tetraspanin-like protein TM4SF1.
miR-203 inhibits arecoline-induced epithelial-mesenchymal transition by regulating secreted frizzled-related protein 4 and transmembrane-4 L six family member 1 in oral submucous fibrosis.
Huang et al., Changsha, China. In Oncol Rep, Jun 2015
We found that miR-203 was significantly downregulated in OSF tissues compared to that in normal buccal mucosa tissues, and that miR-203 negatively regulated secreted frizzled-related protein 4 (SFRP4) and positively regulated transmembrane-4 L six family member 1 (TM4SF1).
Transmembrane-4-L-six-family-1, a potential predictor for poor prognosis, overexpressed in human glioma.
Shi et al., Shijiazhuang, China. In Neuroreport, Jun 2015
Transmembrane-4-L-six-family-1 (TM4SF1), a tumor-associated antigen, is expressed in various human epithelial malignancies including breast, ovarian, lung, and colon carcinomas.
Role of TM4SF1 in regulating breast cancer cell migration and apoptosis through PI3K/AKT/mTOR pathway.
Wang et al., Wuxi, China. In Int J Clin Exp Pathol, 2014
PURPOSE: The purpose of this study was to investigate the effect of transmembrane-4-l-six-family-1 (TM4SF1) on breast cancer cell line MDA-MB-231 invasion and apoptosis and its mechanism through PI3K/AKT/mTOR pathway.
TM4SF1 Promotes Gemcitabine Resistance of Pancreatic Cancer In Vitro and In Vivo.
Logsdon et al., Shanghai, China. In Plos One, 2014
BACKGROUND: TM4SF1 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) and affects the development of this cancer.
TM4SF4 overexpression in radiation-resistant lung carcinoma cells activates IGF1R via elevation of IGF1.
Kim et al., Taejŏn, South Korea. In Oncotarget, 2014
Other members of this family, TM4SF1 (also known as L6-Ag) and TM4SF5, have been shown to be upregulated in multiple tumors and involved in epithelial-to-mesenchymal transition and cell migration.
TM4SF1: a new vascular therapeutic target in cancer.
Jaminet et al., Boston, United States. In Angiogenesis, 2014
Transmembrane-4 L-six family member-1 (TM4SF1) is a small plasma membrane glycoprotein that regulates cell motility and proliferation.
[Construction of a eukaryotic expression vector of TM4SF1 and its effect on migration and invasion of colorectal cancer cells].
Zhou et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, 2014
OBJECTIVE: To construct a eukaryotic expression vector of transmembrane-4-L-six-family-1 (TM4SF1) gene and study its effect on the migration and invasion of colorectal cancer cells.
hsa-miR-141 downregulates TM4SF1 to inhibit pancreatic cancer cell invasion and migration.
Miao et al., Nanjing, China. In Int J Oncol, 2014
Expression of the transmembrane-4-L-six-family-1 (TM4SF1) is high in human pancreatic cancer cells, but the underlying mechanism remains unclear.
Nanopodia--thin, fragile membrane projections with roles in cell movement and intercellular interactions.
Jaminet et al., Israel. In J Vis Exp, 2013
Nanopodia are thin, elongated, largely F-actin-negative membrane projections in endothelial and cancer cells that can be visualized through TM4SF1 (Transmembrane-4-L-six-family-1) immunofluorescence staining.
Model of the Mediator middle module based on protein cross-linking.
Cramer et al., Victoria, Canada. In Nucleic Acids Res, 2013
The Med7/Med21 heterodimer is flanked by subunits Med10 and Med31.
A gene trap mutagenesis screen for genes underlying cellular response to the mood stabilizer lithium.
Pickard et al., Glasgow, United Kingdom. In J Cell Mol Med, 2013
Heterozygous, gene trap integrations were identified within ten genes, eight of which are likely to produce loss-of-function mutations including MED10, MSI2 and three long intergenic non-coding (LINC) RNAs.
TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration.
Jaminet et al., Boston, United States. In Angiogenesis, 2011
TM4SF1, like genuine tetraspanins, serves as a molecular organizer that interacts with membrane and cytoskeleton-associated proteins and uniquely initiates the formation of nanopodia and facilitates cell polarization and migration.
TM4SF1, a novel primary androgen receptor target gene over-expressed in human prostate cancer and involved in cell migration.
Samarut et al., Lyon, France. In Prostate, 2011
Inhibition of cell migration after targeted knockdown of TM4SF1 protein expression suggests its contribution to prostate cancer cell metastasis.
Combined omics analysis identifies transmembrane 4 L6 family member 1 as a surface protein marker specific to human mesenchymal stem cells.
Kim et al., Taejŏn, South Korea. In Stem Cells Dev, 2011
TM4SF1 can serve as a surface protein marker which singly identifies MSCs from diverse cell sources, in particular, fibroblast-rich connective tissues
Genes associated with prognosis after surgery for malignant pleural mesothelioma promote tumor cell survival in vitro.
Sugarbaker et al., Boston, United States. In Bmc Cancer, 2010
We provide evidence that ARHGDIA, COBLL1, and TM4SF1 are negative regulators of apoptosis in cultured tumor cells.
Four-gene expression ratio test for survival in patients undergoing surgery for mesothelioma.
Bueno et al., Boston, United States. In J Natl Cancer Inst, 2009
The gene ratio test with the TM4SF1 gene for survival of patients with malignant pleural mesothelioma has robust predictive value.
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