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Ceramide synthase 2

l-3, Lhx8, Lhx7, LASS2
This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: LAG1, LIM, CAN, V-ATPase, ATPase
Papers on l-3
miR-9 promotes cell proliferation and inhibits apoptosis by targeting LASS2 in bladder cancer.
Wang et al., Kunming, China. In Tumour Biol, Dec 2015
Using luciferase reporter assay, we confirmed that LASS2 was a direct target of miR-9 in bladder cancer cells.
Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2.
Jeong et al., New York City, United States. In Hum Mol Genet, Oct 2015
Lhx6 and Lhx8 encode LIM homeodomain transcription factors, and inactivation of both genes in mice resulted in profound craniofacial defects including cleft secondary palate.
The Evolutionarily Conserved LIM Homeodomain Protein LIM-4/LHX6 Specifies the Terminal Identity of a Cholinergic and Peptidergic C. elegans Sensory/Inter/Motor Neuron-Type.
Kim et al., Taegu, South Korea. In Plos Genet, Aug 2015
Two human LIM-4 orthologs, LHX6 and LHX8, functionally substitute for LIM-4 in C. elegans.
AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer.
Zheng et al., Xuzhou, China. In Oncotarget, Aug 2015
Human 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9) is the gene identified from adipose tissue in 2007.
Overexpression of a Novel Tumor Metastasis Suppressor Gene TMSG1/LASS2 Induces Apoptosis via a Caspase-dependent Mitochondrial Pathway.
Zheng et al., Beijing, China. In J Cell Biochem, Jul 2015
The tumor metastasis suppressor gene 1 (TMSG1), also designated homo sapiens longevity assurance homologue 2 of yeast LAG1 (LASS2), is a novel tumor metastatic suppressor gene.
Transcriptional profiling of five isolated size-matched stages of human preantral follicles.
Andersen et al., Copenhagen, Denmark. In Mol Cell Endocrinol, Mar 2015
Oocyte-specific genes were found to be the most abundant and differentially expressed transcripts and included germ cell transcription factors LHX8 and SOHLH2 which were significantly down-regulated during preantral follicle development.
Direct evidence of brown adipocytes in different fat depots in children.
Körner et al., Leipzig, Germany. In Plos One, 2014
Samples with brown-like adipocytes showed an increased expression of UCP1 (>200fold), PRDM16 (2.8fold), PGC1α and CIDEA while other brown/beige selective markers, such as PAT2, P2RX5, ZIC1, LHX8, TMEM26, HOXC9 and TBX1 were not significantly different between UCP1 positive and negative samples.
Identification and Analysis of Regulatory Elements in Porcine Bone Morphogenetic Protein 15 Gene Promoter.
Wang et al., Xi'an, China. In Int J Mol Sci, 2014
The luciferase assays in combination with a series of deletion of BMP15 promoter sequence show that the -427 to -376 bp region of BMP15 promoter is the primary regulatory element, in which there are a number of transcription factor binding sites, including LIM homeobox 8 (LHX8), newborn ovary homeobox gene (NOBOX), and paired-like homeodomain transcription factor 1 (PITX1).
Lhx8 regulates primordial follicle activation and postnatal folliculogenesis.
Rajkovic et al., Pittsburgh, United States. In Bmc Biol, 2014
Previously, we discovered that global knockouts of germ cell-specific transcriptional co-regulators Sohlh1, Sohlh2, Lhx8, and Nobox, cause rapid oocyte loss and ovarian failure.
A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans.
Scheele et al., Copenhagen, Denmark. In Cell Metab, 2013
We demonstrate that a classical brown expression signature, including upregulation of miR-206, miR-133b, LHX8, and ZIC1 and downregulation of HOXC8 and HOXC9, coexists with an upregulation of two newly established brite/beige markers, TBX1 and TMEM26.
Identification and Characterization of LHX8 DNA Binding Elements.
Choi et al., Seoul, South Korea. In Dev Reprod, 2012
Lhx8 (LIM homeobox 8) gene encodes a LIM homeodomain transcriptional regulator that is preferentially expressed in germ cells and critical for mammalian folliculogenesis.
Expression and epigenetic dynamics of transcription regulator Lhx8 during mouse oogenesis.
Shen et al., Qingdao, China. In Gene, 2012
Lhx8 expression is related with the activation of primordial follicles, which is highly correlated with the demethylation of Lhx8-3' untranslated region and the high acetylation of histone H3.
Silencing of a novel tumor metastasis suppressor gene LASS2/TMSG1 promotes invasion of prostate cancer cell in vitro through increase of vacuolar ATPase activity.
Pei et al., Beijing, China. In J Cell Biochem, 2012
silencing of LASS2/TMSG1 can promote invasion of prostate cancer cell in vitro through increase of V-ATPase activity which accelerated tumor's invasion and metastasis, indicating that LASS2/TMSG1 is a novel tumor metastasis suppressor gene
Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology.
Weiss et al., Philadelphia, United States. In Cell Host Microbe, 2012
Mouse hepatitis virus Ns2 cleaves 2',5'-oligoadenylate, the product of 2',5'-oligoadenylate synthetase, to prevent activation of the cellular endoribonuclease RNase L and consequently block viral RNA degradation.
Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette syndrome.
Grigoriou et al., Greece. In Genes Brain Behav, 2012
Our tagging-single nucleotide polymorphism (tSNP)-based association analysis was negative for Tourette syndrome association with LHX8.
[Identification of nucleolar localization signal sequence of tumor metastasis suppressor gene-1].
Zheng et al., Beijing, China. In Zhonghua Bing Li Xue Za Zhi, 2011
There is a nucleolar localization signal within TMSG-1.
Chronic kidney disease: novel insights from genome-wide association studies.
Heid et al., Regensburg, Germany. In Kidney Blood Press Res, 2010
UMOD, SHROOM3, STC1, LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2/SH2B3, DACH1, UBE2Q2, and SLC7A9 were uncovered as loci associated with estimated glomerular filtration rate (eGFR) and CKD, and CUBN as a locus for albuminuria in cross-sectional data of general population studies.
Genome-wide association studies in nephrology research.
Köttgen, Freiburg, Germany. In Am J Kidney Dis, 2010
For example, common variants in the UMOD and PRKAG2 genes are associated with risk of chronic kidney disease; variants in CLDN14 with risk of kidney stone disease; and variants in or near SHROOM3, STC1, LASS2, GCKR, NAT8/ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, FAM122A/PIP5K1B, ATXN2, DACH1, UBE2Q2/FBXO22, and SLC7A9, with differences in glomerular filtration rate.
New loci associated with kidney function and chronic kidney disease.
Fox et al., Baltimore, United States. In Nat Genet, 2010
Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3).
Genetic and phenotypic heterogeneity in ovarian failure: overview of selected candidate genes.
Simpson, Miami, United States. In Ann N Y Acad Sci, 2007
These include DNA binding proteins and transcription factors like NOBOX and LHX8, and RNA binding proteins like NANOS.
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