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Potassium voltage-gated channel, shaker-related subfamily, beta member 1

Kvbeta1, KCNAB1
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Kv1.4, Kv1.1, Potassium Channel, Kvbeta2, SF-1
Papers on Kvbeta1
The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients.
Souček et al., Praha, Czech Republic. In Medicine (baltimore), 2014
AKR1A1 was significantly overexpressed and AKR1C1-4, KCNAB1, CYP2C19, CYP3A4, and CYP3A5 downregulated in tumors compared with control nonneoplastic tissues after correction for multiple testing.
Gene Mutation Analysis in 253 Chinese Children with Unexplained Epilepsy and Intellectual/Developmental Disabilities.
Jiang et al., Beijing, China. In Plos One, 2014
To our knowledge, we are the first to report KCNAB1 is a disease-causing gene of epilepsy by identifying a novel de novo mutation (c.1062dupCA p.Leu355HisfsTer5) within this gene in one patient with early infantile epileptic encephalopathy (EIEE).
Two further blood pressure loci identified in ion channel genes with a gene-centric approach.
Stanton et al., Leicester, United Kingdom. In Circ Cardiovasc Genet, 2014
These were rs2228291, in the chloride channel gene CLCN2, and rs10513488, in the potassium channel gene KCNAB1.
Meta-analysis of genome-wide association studies in multiethnic Asians identifies two loci for age-related nuclear cataract.
Cheng et al., Singapore, Singapore. In Hum Mol Genet, 2014
The first locus was at chromosome 3q25.31 in KCNAB1 (rs7615568, fixed-effect Pmeta = 2.30 × 10(-8); random-effect Pmeta = 1.08 × 10(-8)).
Identification of rare variants for hypertension with incorporation of linkage information.
Hsu et al., New Haven, United States. In Bmc Proc, 2013
KCNAB1 (p = 5.8E-4), and MYRIP (p = 5.79E-6).
A new locus for familial temporal lobe epilepsy on chromosome 3q.
Pandolfo et al., Brussels, Belgium. In Epilepsy Res, 2013
KCNAB1, encoding a voltage-gated, shaker-related potassium channel, and NLGN1, encoding a member of a family of neuronal cell surface protein were excluded as disease causing mutations.
Pathway analysis of a genome-wide association study in schizophrenia.
Song et al., Seoul, South Korea. In Gene, 2013
However, 13 of candidate genes (RDH8, ACVR1, PSMD9, KCNAB1, SLC17A3, ARCN1, COG7, STAB2, LRPAP1, STAB1, CXCL16, COL4A4, EXOSC3) and 9 of candidate pathways were novel.
Molecular differential diagnosis of follicular thyroid carcinoma and adenoma based on gene expression profiling by using formalin-fixed paraffin-embedded tissues.
Jarzab et al., Gliwice, Poland. In Bmc Med Genomics, 2012
RESULTS: Five of 8 genes selected from training datasets (ELMO1, EMCN, ITIH5, KCNAB1, SLCO2A1) were amplified by qPCR in FFPE material from an independent sample set.
Selective expression of KCNS3 potassium channel α-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex.
Hashimoto et al., Kanazawa, Japan. In Plos One, 2011
Based on previously reported expression patterns in the cortex of mice and humans, we selected four genes: KCNS3, LHX6, KCNAB1, and PPP1R2, encoding K(+) channel Kv9.3 modulatory α-subunit, LIM homeobox protein 6, K(+) channel Kvβ1 subunit, and protein phosphatase 1 regulatory subunit 2, respectively, and examined their colocalization with PV or SST mRNAs in the human prefrontal cortex using dual-label in situ hybridization with (35)S- and digoxigenin-labeled antisense riboprobes.
Oxidation of NADPH on Kvbeta1 inhibits ball-and-chain type inactivation by restraining the chain.
Zhou et al., New York City, United States. In Proc Natl Acad Sci U S A, 2011
Oxidation of NADPH on Kvbeta1 inhibits ball-and-chain type inactivation by restraining the chain.
Association of intronic variants of the KCNAB1 gene with lateral temporal epilepsy.
Nobile et al., Padova, Italy. In Epilepsy Res, 2011
These results support KCNAB1 as a susceptibility gene for lateral temporal epilepsy , in agreement with previous studies showing that this gene may alter susceptibility to focal epilepsy.
Kv1.5-Kv beta interactions: molecular determinants and pharmacological consequences.
Valenzuela et al., Madrid, Spain. In Mini Rev Med Chem, 2010
Kv beta 1.3 assemblies with Kv alpha 1.5 and modifies its gating and pharmacology.
The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials.
Dermietzel et al., Bochum, Germany. In Febs J, 2009
The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials.
Structural determinants of Kvbeta1.3-induced channel inactivation: a hairpin modulated by PIP2.
Sanguinetti et al., Salt Lake City, United States. In Embo J, 2009
Double-mutant cycle analysis indicates that R5 of Kvbeta1.3 interacts with A501 and T480 of Kv1.5, residues located deep within the pore of the channel.
Structural determinants of monohydroxylated bile acids to activate beta 1 subunit-containing BK channels.
Dopico et al., Memphis, United States. In J Lipid Res, 2008
A structural model of fatty acid (lithocholate) insertion and docking onto specific Kcnab1 transmembrane domain 2 interface regions is postulated that explains the differential efficacy of bile acids on large channel activity.
Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study.
Goldstein et al., Dublin, Ireland. In Lancet Neurol, 2007
Variations in the genes KCNAB1, GABRR2, KCNMB4, SYN2, and ALDH5A1 were most notable.
Molecular determinants of voltage-gated potassium currents in vascular smooth muscle.
Cox, Lancaster, United States. In Cell Biochem Biophys, 2004
Based on electro physiological and expression studies, it is likely that the latter two components are represented by a heteromultimeric complex of Kv1.2 with either Kv1.4 or Kv1.5 and a Kvbeta1 subunit, and by at least Kv2.1, respectively.
Functional and molecular aspects of voltage-gated K+ channel beta subunits.
Storm et al., Hamburg, Germany. In Ann N Y Acad Sci, 1999
Loss of function of Kv beta 1.1 subunits leads to a reduction of A-type Kv channel activity in hippocampal and striatal neurons of knock-out mice.
K+ channel modulation in arterial smooth muscle.
Quayle et al., Leicester, United Kingdom. In Acta Physiol Scand, 1998
Kv2.1, Kv9.3, Kv beta 1-beta 4, slo alpha and beta, Kir2.1, Kir6.2, and SUR1 and SUR2.
Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit.
Pongs et al., Hamburg, Germany. In Nature, 1994
We have cloned a beta-subunit (Kv beta 1) that is specifically expressed in the rat nervous system.
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