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Potassium voltage-gated channel, Shal-related subfamily, member 2

Kv4.2, KCND2
a potassium channel responsible for transient outward K+ currents in cardiomyocytes [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Kv1.4, Kv4.3, HAD, POLYMERASE, KChIP2
Papers on Kv4.2
G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition.
Pan et al., Houston, United States. In Nat Neurosci, Dec 2015
We found that nerve injury increased dimethylation of Lys9 on histone H3 (H3K9me2) at Kcna4, Kcnd2, Kcnq2 and Kcnma1 promoters but did not affect levels of DNA methylation on these genes in DRGs.
IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Circadian Period of PER2 Expression in the Suprachiasmatic Nucleus.
Herzog et al., Saint Louis, United States. In J Biol Rhythms, Oct 2015
Recently, we reported that mice deficient for either Kcna4 (Kv1.4(-/-)) or Kcnd2 (Kv4.2(-/-); but not Kcnd3, Kv4.3(-/-)), voltage-gated K(+) (Kv) channel pore-forming subunits that encode subthreshold, rapidly activating, and inactivating K(+) currents (IA), have shortened (0.5 h) circadian periods in SCN firing and in locomotor activity compared with wild-type (WT) mice.
Cold-Inducible RNA-Binding Protein Regulates Cardiac Repolarization by Targeting Transient Outward Potassium Channels.
Chen et al., Shanghai, China. In Circ Res, Jun 2015
Furthermore, our findings uncovered that CIRP protein selectively bonded to KCND2 and KCND3 mRNAs encoding the functional α-subunits of Ito channel proteins.
Variations in potassium channel genes are associated with distinct trajectories of persistent breast pain after breast cancer surgery.
Aouizerat et al., San Francisco, United States. In Pain, Mar 2015
In addition, 3 SNPs and 1 haplotype across 4 genes (ie, KCND2, KCNJ3, KCNJ6, KCNK9) were associated with membership in the Severe Pain class.
Electrophysiological and morphological maturation of murine fetal cardiomyocytes during electrical stimulation in vitro.
Hescheler et al., Köln, Germany. In J Cardiovasc Pharmacol Ther, 2015
Expression of ion channel subunits Kcnd2, Slc8a1, Cacna1, Kcnh2, and Kcnb1 was analyzed by quantitative reverse-transcriptase polymerase chain reaction.
Evaluation of genes encoding for the transient outward current (Ito) identifies the KCND2 gene as a cause of J-wave syndrome associated with sudden cardiac death.
Gollob et al., Halifax, Canada. In Circ Cardiovasc Genet, 2014
METHODS AND RESULTS: Comprehensive mutational analysis was performed on I(to)-encoding KCNA4, KCND2, and KCND3 genes, as well as the previously described J-wave-associated KCNJ8 gene, in 51 unrelated patients with ECG evidence defining a J-wave syndrome.
Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice.
Maylie et al., Portland, United States. In Plos One, 2014
SK2- and KV4.2-containing K+ channels modulate evoked synaptic potentials in CA1 pyramidal neurons.
Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation.
Nelson et al., Los Angeles, United States. In Hum Mol Genet, 2014
A de novo variant was identified in the KCND2 gene, which encodes the Kv4.2 potassium channel.
Dominant frequency increase rate predicts transition from paroxysmal to long-term persistent atrial fibrillation.
Jalife et al., Norfolk, United States. In Circulation, 2014
NaV1.5, and KV4.2 decrease; Kir2.3 increase), was already present at the transition and persisted for 1 year of follow up.
Identification of genes promoting skin youthfulness by genome-wide association study.
Barzilai et al., Redwood City, United States. In J Invest Dermatol, 2014
The six SNPs were interrogated by MassARRAY in a replication group (n=436) with confirmation of rs6975107, an intronic region of KCND2 (potassium voltage-gated channel, Shal-related family member 2) (Pgenotype=0.023).
The prognostic role of intragenic copy number breakpoints and identification of novel fusion genes in paediatric high grade glioma.
Jones et al., United Kingdom. In Acta Neuropathol Commun, 2013
We observed numerous gene disruptions by iCNA due to both deletions and amplifications, targeting known HGG-associated genes such as RB1 and NF1, putative tumour suppressors such as FAF1 and KIDINS220, and novel candidates such as PTPRE and KCND2.
Effect of ouabain on myocardial remodeling in rats.
Huang et al., Xi'an, China. In Exp Ther Med, 2013
The expression levels of voltage-gated potassium channel 4.2 (KV4.2) were detected by real-time quantitative reverse transcription-polymerase chain reaction.
I(A) channels encoded by Kv1.4 and Kv4.2 regulate neuronal firing in the suprachiasmatic nucleus and circadian rhythms in locomotor activity.
Herzog et al., Saint Louis, United States. In J Neurosci, 2012
Kv1.4- and Kv4.2-encoded I(A) channels regulate the intrinsic excitability of SCN neurons during the day and night and determine the period and amplitude of circadian rhythms in SCN neuron firing and locomotor behavior.
Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites.
Bernard et al., Marseille, France. In J Biol Chem, 2012
Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites.
The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels.
Nerbonne et al., Saint Louis, United States. In J Neurosci, 2012
The results presented here identify Navbeta1 as a component of native neuronal Kv4.2-encoded I(A) channel complexes and a novel regulator of I(A) channel densities and neuronal excitability.
Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy.
Kurebayashi et al., Tokyo, Japan. In Plos One, 2011
The combined down-regulation of Kv4.2, Kv1.5 and KChIP2 prior to the onset of HF may play an important role in the premature sudden death in this DCM model.
Kv4 potassium channels modulate hippocampal EPSP-spike potentiation and spatial memory in rats.
Mourre et al., Marseille, France. In Learn Mem, 2011
This study showed that Significant differences in Kv4.2 and Kv4.3 mRNA levels in conditioned rats. and up regulation in the brain.
[Genetics components in patients with temporal lobe epilepsy].
Alonso-Cerezo et al., Madrid, Spain. In Rev Neurol, 2009
We have reviewed the following genes; LGI1, PDYN (prodynorphin), interleucine 1beta, PRPN (prion protein), ApoE (apolipoprotein E), GABBR1, SCN1A, SCN1B, KCNA1, KCND2.
Strategy for a genetic assessment of antipsychotic and antidepressant-related proarrhythmia.
Serretti et al., Bologna, Italy. In Curr Med Chem, 2007
So far, a number of genes have been associated with arrhythmia: SCN5A, SCN4B, CACNL1AC, KCNH2, KCNQ1, KCNE1, ANK2, ALG10, KCNJ2, KCNE2, RYR2, KCND3, KCND2, ACE, NOS1AP, CASQ2 and Rad.
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