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Potassium voltage gated channel, Shab-related subfamily, member 2

Kv2.2, KCNB2
delayed rectifier potassium channel [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: OUT, SCN5A, fibrillin-1, TOP, alpha1A-adrenergic receptor
Papers on Kv2.2
[Replicative study of susceptibility to childhood-onset schizophrenia in Kazakhs].
Svyatova et al., In Genetika, Feb 2015
An association of early-onset schizophrenia with genetic markers in three genes (VRK2, KCNB2, and CPVL) was found.
Disease-targeted sequencing of ion channel genes identifies de novo mutations in patients with non-familial Brugada syndrome.
Lin et al., Taipei, Taiwan. In Sci Rep, 2013
Five de novo mutations were identified in four genes (SCNN1A, KCNJ16, KCNB2, and KCNT1) in three BrS patients (20%).
Candidate luminal B breast cancer genes identified by genome, gene expression and DNA methylation profiling.
Chaffanet et al., Marseille, France. In Plos One, 2013
In a meta-analysis of next-generation sequencing data in 875 BCs, KCNB2 mutations were associated with luminal B cases while candidate TSGs MDN1 (6q15) and UTRN (6q24), were mutated in this subtype.
Genome-wide association studies of maximum number of drinks.
Wang et al., Johnson City, United States. In J Psychiatr Res, 2013
Furthermore, several SNPs (rs17144687 near DTWD2, rs12108602 near NDST4, and rs2128158 in KCNB2) showed significant associations with MaxDrinks (p < 5 × 10(-7)) in the meta-analysis.
Dynamic genetic linkage of intermediate blood pressure phenotypes during postural adaptations in a founder population.
Hamet et al., Montréal, Canada. In Physiol Genomics, 2013
ADRA1A, APO, CAST, CORIN, CRHR1, EDNRB, FGF2, GC, GJA1, KCNB2, MMP3, NPY, NR3C2, PLN, TGFBR2, TNFRSF6, and TRHR showed evidence of linkage with any phenotype in the supine position and not upon standing, whereas AKR1B1, CD36, EDNRA, F5, MMP9, PKD2, PON1, PPARG, PPARGC1A, PRKCA, and RET were specifically linked to standing phenotypes.
MicroRNA-1 accelerates the shortening of atrial effective refractory period by regulating KCNE1 and KCNB2 expression: an atrial tachypacing rabbit model.
Hou et al., Jinan, China. In Plos One, 2012
METHODS AND RESULTS: QRT-PCR and western blot were used to detect the expression of the miR-1, KCNE1, and KCNB2 genes after 1-week of right atrial tachypacing in New Zealand white rabbits.
Expression and function of K(V)2-containing channels in human urinary bladder smooth muscle.
Petkov et al., Columbia, United States. In Am J Physiol Cell Physiol, 2012
stromatoxin-1 -sensitive KV2-containing channels are expressed in detrusor smooth muscle (DSM); they control DSM excitability, intracellular Ca2+ levels, and myogenic and nerve-evoked contractions
Statistical epistasis and functional brain imaging support a role of voltage-gated potassium channels in human memory.
Papassotiropoulos et al., Basel, Switzerland. In Plos One, 2010
A significant, episodic memory-related interaction between two markers located in potassium channel genes (KCNB2 and KCNH5) was observed (P(nominal combined)=0.000001).
Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice.
Misonou et al., Baltimore, United States. In J Comp Neurol, 2010
These data offer Kv2.2 as a molecular target to study the role of the specific subpopulation of basal forebrain GABAergic neurons.
A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;p11.2) and leads to Brachydactyly Type E.
Bähring et al., Berlin, Germany. In Hum Mol Genet, 2010
and a disrupted KCNB2 on 8q13.
A high-density association screen of 155 ion transport genes for involvement with common migraine.
Palotie et al., Brisbane, Australia. In Hum Mol Genet, 2008
SNPs within 12 genes (KCNB2, KCNQ3, CLIC5, ATP2C2, CACNA1E, CACNB2, KCNE2, KCNK12, KCNK2, KCNS3, SCN5A and SCN9A) with promising nominal association (0.00041 < P < 0.005) in the Finnish sample were selected for replication.
Localization of Kv2.2 protein in Xenopus laevis embryos and tadpoles.
Ribera et al., Aurora, United States. In J Comp Neurol, 2008
Results describe the localization of Kv2.2 protein in Xenopus laevis embryos and tadpoles and support different roles for Kv2.1 and Kv2.2 during development and neuronal signaling.
Initial segment Kv2.2 channels mediate a slow delayed rectifier and maintain high frequency action potential firing in medial nucleus of the trapezoid body neurons.
Forsythe et al., Leicester, United Kingdom. In J Physiol, 2008
It was concluded that Kv2.2-containing channels have a distinctive initial segment location and crucial function in maintaining AP amplitude by regulating the interspike potential during high frequency firing.
Kv2 subunits underlie slowly inactivating potassium current in rat neocortical pyramidal neurons.
Foehring et al., Memphis, United States. In J Physiol, 2007
Kv2.2 subunits make a minor contribution to slowly inactivating potassium currents in neocortical pyramidal neurons.
Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.
Benjamin et al., Framingham, United States. In Bmc Med Genet, 2006
LV systolic dimension, rs10504543 (KCNB2, p = 5.18*10(-6)); LV mass, rs10498091 (p = 5.68*10(-6)); Left atrial size, rs1935881 (FAM5C, p = 6.56*10(-6)); exercise heart rate, rs6847149 (NOLA1, p = 2.74*10(-6)); exercise systolic blood pressure, rs2553268 (WRN, p = 6.3*10(-6));
RNA microarray analysis of channels and transporters in normal and fetal Down syndrome (trisomy 21) brain.
Sohn et al., Vienna, Austria. In J Neural Transm Suppl, 2002
15 out of 96 RNAs of the array were observed on the films in both groups during this gestational period consisting of genes for potassium, sodium, calcium channels and transporters (ASIC3, ATP1B1, CACNA1B, KCNB2, KCNC1, KCND2, KCNF1, KCNN1, KCNN3, hKCa4, KCNQ2, lipid transfer protein II, SCN2B, acetyl choline transporter, glutamate transporter3).
Angiotensin II type 1 receptor-mediated inhibition of K+ channel subunit kv2.2 in brain stem and hypothalamic neurons.
Sumners et al., Gainesville, United States. In Circ Res, 1999
Collectively, these data suggest the presence of Kv2.2 and Kv3.1b.
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