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X-ray repair complementing defective repair in Chinese hamster cells 5

Ku80, Ku86, XRCC5
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IRBP, CAN, HAD, p53, XRCC4
Papers using Ku80 antibodies
Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity.
Blagosklonny Mikhail V., In PLoS ONE, 2004
... The following commercial antibodies were used: anti-DNA-PKcs pan mouse monoclonal, anti-Ku86 mouse monoclonal and anti-tubulin mouse monoclonal (Santa Cruz Biotechnology, Santa Cruz, CA); anti-DNA-PKcs ...
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM.
Muzi-Falconi Marco, In PLoS ONE, 2003
... BRCA1 (#9009), or phosphorylated histone 2A.X (#9718); 2) Lab Vision (Fremont, CA) against Ku70 (#MS-329), Ku80 (#MS-332), and DNA-PK (#MS-370); and 3) Santa Cruz Biotechnology, Inc ...
Cytoscape: a software environment for integrated models of biomolecular interaction networks.
Uversky Vladimir N., In PLoS ONE, 2002
... Antibodies for CD44, DDB-1, DJ-1 and Ku80 (XRCC5) were purchased from Cell Signaling Technology (Danvers, MA) ...
Papers on Ku80
Moderate stress responses and specific changes in polyamine metabolism characterize Scots pine somatic embryogenesis.
Vuosku et al., Oulu, Finland. In Tree Physiol, Feb 2016
Cellular PA contents and the expression of the PA metabolism genes arginine decarboxylase (ADC), spermidine synthase (SPDS), thermospermine synthase (ACL5) and diamine oxidase (DAO) were analyzed, as well as the expression of catalase (CAT), DNA repair genes (RAD51, KU80) and autophagy-related genes (ATG5, ATG8) throughout the induction of somatic embryo formation in Scots pine SE cultures.
Association between single-nucleotide polymorphisms in DNA double-strand break repair genes and prostate cancer aggressiveness in the Spanish population.
Lara et al., Las Palmas de Gran Canaria, Spain. In Prostate Cancer Prostatic Dis, Feb 2016
Single-nucleotide polymorphisms (SNPs) in four genes directly (XRCC5 (X-ray repair complementing defective repair in Chinese hamster cells 5) and XRCC6 (X-ray repair complementing defective repair in Chinese hamster cells 6)) or indirectly (PARP1 and major vault protein (MVP)) involved in non-homologous end joining were examined in 494 Spanish PCa patients.
Highly efficient CRISPR mutagenesis by microhomology-mediated end joining in Aspergillus fumigatus.
Lu et al., Nanjing, China. In Fungal Genet Biol, Jan 2016
Moreover, clinical isolates that have a wild-type ku80 background without any selection nutrition marker especially suffer from low homologous integration efficiency.
xIP-MS: topological analysis of chromatin-associated protein complexes using single affinity purification.
Vermeulen et al., Netherlands. In Mol Cell Proteomics, Dec 2015
We then applied xIP-MS to the chromatin-associated cohesin (SMC1A/3), XRCC5/6 (Ku70/86), and MCM complexes, and we provide novel structural and biological insights into their architectures and molecular function.
Effect of transporter and DNA repair gene polymorphisms to lung cancer chemotherapy toxicity.
Liu et al., Changsha, China. In Tumour Biol, Oct 2015
XRCC5 (rs1051685, rs6941) and AQP2 (10875989, rs3759125) polymorphisms were associated with hematologic toxicity.
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.
Kühn et al., Berlin, Germany. In Nat Biotechnol, May 2015
To enhance HDR, enabling the insertion of precise genetic modifications, we suppressed the NHEJ key molecules KU70, KU80 or DNA ligase IV by gene silencing, the ligase IV inhibitor SCR7 or the coexpression of adenovirus 4 E1B55K and E4orf6 proteins in a 'traffic light' and other reporter systems.
Blood-based DNA methylation of DNA repair genes in the non-homologous end-joining (NEHJ) pathway in patient with glioma.
Zhang et al., Shanghai, China. In Int J Clin Exp Pathol, 2014
UNLABELLED: To investigate the blood-based DNA methylation of repair genes including LIG4, XRCC4, XRCC5, XRCC6 and XRCC7 that involved in non-homologous end-joining (NEHJ) DNA repair pathway in patients with glioma.
Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes.
Moskalev et al., Moscow, Russia. In Sci Rep, 2014
Overexpressed genes included those involved in recognition of DNA damage (homologs of HUS1, CHK2), nucleotide and base excision repair (homologs of XPF, XPC and AP-endonuclease-1), and repair of double-stranded DNA breaks (homologs of BRCA2, XRCC3, KU80 and WRNexo).
Specificity of the dRP/AP lyase of Ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends.
Ramsden et al., Chapel Hill, United States. In J Biol Chem, 2012
Specificity of the dRP/AP lyase of Ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends
Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination.
Chen et al., Dallas, United States. In Dna Repair (amst), 2012
Ku70/80 binds to DNA double strand breaks (DSB) in all cell cycle stages and is likely actively displaced from DSB ends to free the DNA ends for DNA end resection and thus homologous recombination to occur.
Ku80 functions as a tumor suppressor in hepatocellular carcinoma by inducing S-phase arrest through a p53-dependent pathway.
Chen et al., Wuhan, China. In Carcinogenesis, 2012
study found Ku80 was downregulated in hepatocellular carcinoma(HCC) and Ku80 downregulation was correlated with elevated HBV-DNA load and liver cirrhosis; suggested an underlying mechanism in which Ku80 functions as a tumor suppressor in HCC by inducing S-phase arrest through a p53-dependent pathway
The E3 ligase RNF8 regulates KU80 removal and NHEJ repair.
Chen et al., Houston, United States. In Nat Struct Mol Biol, 2012
The authors find that RNF8 regulates the abundance of the nonhomologous end-joining (NHEJ) repair protein KU80 at sites of DNA damage.
Association between XRCC5, 6 and 7 gene polymorphisms and the risk of breast cancer: a HuGE review and meta-analysis.
Shang et al., Shenyang, China. In Asian Pac J Cancer Prev, 2011
Recent publications indicated that XRCC5, XRCC6 and XRCC7 genes may participate in the pathogenesis of breast cancer.
Genetic analysis of IREB2, FAM13A and XRCC5 variants in Chinese Han patients with chronic obstructive pulmonary disease.
Deng et al., Changsha, China. In Biochem Biophys Res Commun, 2011
these results support that FAM13A rs2869967 and XRCC5 rs3821104 are associated with COPD in Chinese Han population.
Role of the XRCC5/XRCC6 dimer in carcinogenesis and pharmacogenomics.
Wu et al., Mingyue, China. In Pharmacogenomics, 2011
the studies investigating the association between the XRCC5/XRCC6 dimer and the susceptibility to multiple cancers and discuss its role in carcinogenesis and its potential application to anticancer drug discovery were summarized.
Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal tract.
Keller et al., München, Germany. In Adv Exp Med Biol, 2005
Analysis of expression of 5-FU-(e.g., TS, DPD, and TP) and cisplatin-(e.g., ERCC1, ERCC4, GADD45A, and KU80) related genes, demonstrated an association of DPD expression with response and survival.
Non-homologous end-joining factors of Saccharomyces cerevisiae.
Chovanec et al., Bratislava, Slovakia. In Fems Microbiol Rev, 2004
The budding yeast Saccharomyces cerevisiae repairs DSB primarily by homologous recombination (HR), despite the presence of the KU70, KU80, DNA ligase IV and XRCC4 homologues, essential factors of the mammalian non-homologous end-joining (NHEJ) machinery.
The XRCC genes: expanding roles in DNA double-strand break repair.
Zdzienicka et al., United Kingdom. In Dna Repair (amst), 2004
Thus, XRCC5-7 (DNA-PK)-dependent NHEJ commonly occurs with fidelity, perhaps by aligning ends accurately in the absence of sequence microhomologies, but NHEJ-deficient mice show reduced frequencies of mutation.
Yeast DNA ligase IV mediates non-homologous DNA end joining.
Lieber et al., Saint Louis, United States. In Nature, 1997
The discovery of homologues from the yeast Saccharomyces cerevisiae of the human Ku DNA-end-binding proteins (HDF1 and KU80) has established that this organism is capable of non-homologous double-strand end joining (NHEJ), a form of DNA double-strand break repair (DSBR) active in mammalian V(D)J recombination.
Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination.
Jeggo et al., Boston, United States. In Science, 1994
The human XRCC5 DNA repair gene, which complements this mutant, is shown here through genetic and biochemical evidence to be the 80-kilodalton subunit of the Ku protein.
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