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Connector enhancer of kinase suppressor of Ras 1

KSR, CNKI, KSR1, Kinase suppressor of Ras
This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CIs, HAD, Vasoactive Intestinal Peptide, CAN, OUT
Papers using KSR antibodies
Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits.
McCabe Brian D., In PLoS ONE, 2006
... Induction of the TAG1 ES cells was performed using KSR medium supplemented with 1 µg/ml doxycycline (Clontech, UK) ...
A comparison of the quality of Cochrane reviews and systematic reviews published in paper-based journals
Zhang Xin et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2001
We performed a comprehensive search on CNKI (China National Knowledge Infrastructure), CBM (Chinese Biomedical Database), VIP (Chongqing VIP ...
Papers on KSR
A Meta-analysis on the Effect of Ulinastatin on Serum Levels of C-Reactive Protein, Interleukin 6, and Tumor Necrosis Factor Alpha in Asian Patients with Acute Pancreatitis.
Qin et al., Tianjin, China. In Genet Test Mol Biomarkers, Feb 2016
METHODS: Two investigators independently searched 11 databases, including PUBMED, EBSCO, Ovid, SpringerLink, Wiley, Web of Science, Cochrane Library, Wanfang database, China National Knowledge Infrastructure (CNKI), Chinese Journal Full-text Database, and China Biomedicine Database.
Association Between VDR FokI Polymorphism and Intervertebral Disc Degeneration.
Li et al., Shanghai, China. In Genomics Proteomics Bioinformatics, Feb 2016
Candidate articles were retrieved from PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and China Biology Medical (CBM) with strict inclusion criteria in January 2015.
Hyper Expression of Mucin 5ac Indicates Poor Cancer Prognoses: A Meta-Analysis.
Ren et al., Nanjing, China. In Medicine (baltimore), Jan 2016
The aim of the study was to explore the association between mucin 5ac expression and cancer prognosis.A systematically comprehensive search was performed through PubMed, the Web of Science, and the China National Knowledge Infrastructure (CNKI).
The Efficacy of Erlotinib Versus Conventional Chemotherapy for Advanced Nonsmall-Cell Lung Cancer: A PRISMA-Compliant Systematic Review With Meta-Regression and Meta-Analysis.
Zhou et al., Zunyi, China. In Medicine (baltimore), Jan 2016
Erlotinib is the first-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), the National Comprehensive Cancer Network (NCCN) guidelines recommend it as a first-line agent in patients with sensitizing EGFR mutations.We conducted a meta-analysis to compare the efficacy of erlotinib and chemotherapy for advanced NSCLC, and evaluated the efficacy of them to provide references for further clinical practice and research.PubMed, EMBASE, CBM, CNKI, WanFang database, The Cochrane library, and Web of Science, as well as abstracts presented at ASCO conferences and
Association of Matrix Metalloproteinase-9 Gene -1562C/T Polymorphism with Essential Hypertension: A Systematic Review and Meta-Analysis Article.
Zhang et al., Shanghai, China. In Iran J Public Health, Nov 2015
METHODS: To evaluate the association of MMP-9 -1562C/T polymorphism with essential hypertension, we performed a meta-analysis by combining all available independent case-control studies (n=6).A systematic literature search of PubMed, Web of Science, Scopus and CNKI (Chinese National Knowledge Infrastructure) databases was conducted by two researchers independently for all relevant articles published before March 2015.
[Research progress of mechanism of functional dyspepsia treated with acupuncture].
Liang et al., In Zhongguo Zhen Jiu, Sep 2015
Literature about functional dyspepsia treated with acupuncture in recent 5 years is retrieved in China National Knowledge Infrastructure (CNKI), Wanfang database and PubMed.
Association between sodium iodide symporter and differentiated Thyroid cancer: a meta-analysis of 9 studies.
Dong et al., Jinan, China. In Int J Clin Exp Med, 2014
DATA SOURCES: PUBMED, Sinomed, CNKI, Wanfang and VIP were searched for relevant case-control studies up to now.
Prognostic value of cancer stem cell marker CD133 expression in pancreatic ductal adenocarcinoma (PDAC): a systematic review and meta-analysis.
Zheng et al., Shanghai, China. In Int J Clin Exp Pathol, 2014
A search in the Medline, EMBASE and Chinese CNKI (China National Knowledge Infrastructure) database (up to 1 March 2015) was performed using the following keywords pancreatic cancer, CD133, AC133, prominin-1 etc.
Aldehyde dehydrogenase 2 (ALDH2) polymorphism gene and coronary artery disease risk: a meta-analysis.
Kui et al., Chengdu, China. In Genet Mol Res, 2014
We searched the ISI, Medline (Ovid), PubMed, CNKI, Wanfang, and Weipu Databases.
AGER genetic polymorphisms increase risks of breast and lung cancers.
Liu et al., Jinzhou, China. In Genet Mol Res, 2014
A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases.
The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1.
Rottapel et al., Toronto, Canada. In Cancer Cell, 2014
Cellular transformation by oncogenic RAS engages the MAPK pathway under strict regulation by the scaffold protein KSR-1.
KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation.
Farooqi et al., In Cell, 2013
Kinase suppressor of Ras 2 (KSR2) is an intracellular scaffolding protein involved in multiple signaling pathways.
Suppression of Ras/Mapk pathway signaling inhibits Myc-induced lymphomagenesis.
Eischen et al., Nashville, United States. In Cell Death Differ, 2012
The loss of Ksr1 inhibits Ras/Mapk pathway signaling leading to increased Myc-induced B-cell apoptosis, and this results in reduced B-cell transformation and lymphoma development.
Kinase suppressor of Ras (KSR1) modulates multiple kit-ligand-dependent mast cell functions.
Clapp et al., Indianapolis, United States. In Exp Hematol, 2011
Genetic disruption of KSR1 results in striking reductions in kit-ligand-mediated proliferation & degranulation and impacts the biochemical activation of p21-activated kinase.
Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K.
Chan et al., Indianapolis, United States. In Leuk Res, 2011
Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K.
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.
Barford et al., London, United Kingdom. In Nature, 2011
Kinase suppressor of Ras (KSR) functions as an essential scaffolding protein to coordinate the assembly of Raf-MEK-ERK complexes.
Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections.
Gulbins et al., Essen, Germany. In Nat Med, 2011
findings suggest that Ksr1 functions as a previously unknown scaffold that enhances iNOS activity and is therefore crucial for the pulmonary response to P. aeruginosa infections
Simulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilin.
Low et al., Singapore, Singapore. In Plos One, 2010
simulations constitute a multi-dimensional exploration of how EGF-dependent EGFR endocytosis and ERK activation are dynamically affected by scaffolds KSR and MP1, co-regulated by Cbl-CIN85 and Endophilin A1
Regulation of glucose homeostasis by KSR1 and MARK2.
Lewis et al., Omaha, United States. In Plos One, 2010
a model whereby MARK2 negatively regulates insulin sensitivity in peripheral tissue through inhibition of KSR1
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade.
Scott et al., Seattle, United States. In Nat Cell Biol, 2010
We demonstrate that the A-kinase-anchoring protein AKAP-Lbc and the scaffolding protein kinase suppressor of Ras (KSR-1) form the core of a signalling network that efficiently relay signals from RAF, through MEK, and on to ERK1/2.
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