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Cadherin 16

Ksp-cadherin, Kidney-specific cadherin, CDH16, cadherin 16
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011] (from NCBI)
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Top mentioned proteins: XRCC1, E-cadherin, p27, CK7, CAN
Papers on Ksp-cadherin
Identification of Genes Associated with Papillary Thyroid Carcinoma (PTC) for Diagnosis by Integrated Analysis.
Pang et al., Chongqing, China. In Horm Metab Res, Feb 2016
Among the top 10 up- and downregulated genes, the dysregulation genes of TPO, CDH16, and MPPED2 may be closely related to the tumorigenesis of PTC.
Expanding the clinical, allelic, and locus heterogeneity of retinal dystrophies.
Alkuraya et al., Riyadh, Saudi Arabia. In Genet Med, Oct 2015
Whole-exome sequencing revealed the likely candidate as AGBL5 and CDH16, respectively.
Immunohistochemical characterization of renal tumors in patients with Birt-Hogg-Dubé syndrome.
Furuya et al., Yokohama, Japan. In Pathol Int, Mar 2015
Almost all chromophobe RCCs and HOCTs revealed positive staining for S100A1, Ksp-cadherin and CD82.
Alteration of cell-cell and cell-matrix adhesion in urothelial cells: an oncogenic mechanism for mutant FGFR3.
Knowles et al., Leeds, United Kingdom. In Mol Cancer Res, 2015
Silencing of endogenous mutant FGFR3 in bladder cancer cells induced converse changes in transcript levels of CDH16, PLAU, MMP10, EPCAM, TNC, and HAS3, confirming them as downstream gene targets of mutant FGFR3.
[Clinicopathologic features of clear cell papillary renal cell carcinoma].
Zhou et al., Nanjing, China. In Zhonghua Bing Li Xue Za Zhi, 2014
Ksp-cadherin was positively expressed in 8 cases.VHL gene mutations were not found in all 11 cases.
Mucinous tubular and spindle cell carcinoma of the kidney with prominent papillary component, a non-classic morphologic variant. A histologic, immunohistochemical, electron microscopic and fluorescence in situ hybridization study.
Zou et al., Baltimore, United States. In Pathol Res Pract, 2014
Kidney-specific cadherin, cytokeratin 34betaE12 and TFE3 stains were negative in the tumor.
t(6;11) renal cell carcinoma (RCC): expanded immunohistochemical profile emphasizing novel RCC markers and report of 10 new genetically confirmed cases.
Argani et al., Los Angeles, United States. In Am J Surg Pathol, 2014
In contrast to a prior study's findings, only a minority of cases labeled for Ksp-cadherin (3 of 19 cases).
Coexistent loss of INI1 and BRG1 expression in a rhabdoid renal cell carcinoma (RCC): implications for a possible role of SWI/SNF complex in the pathogenesis of RCC.
Zhou et al., Nanjing, China. In Int J Clin Exp Pathol, 2013
Immunohistochemically, the tumor were positive for BRM, PBRM1, ARID1A, CD10, CKpan, Vimentin, carbonic anhydrase IX (CA-IX), and P504S (AMACR) but negative for INI1, BRG1, HMB45, melan A, CK7, CD117, Ksp-cadherin, TFEB, TFE3, and Cathepsin K. We detected all three exons status of the VHL gene of the tumor and observed 1 somatic mutations in 1st exon.
Expression of the Na+/K+-transporting ATPase gamma subunit FXYD2 in renal tumors.
Ladenson et al., Saint Louis, United States. In Mod Pathol, 2013
For comparison, this subset was also stained for kidney-specific cadherin (Ksp-cadherin).
Renal cell carcinomas with t(6;11)(p21;q12) presenting with tubulocystic renal cell carcinoma-like features.
Shi et al., Nanjing, China. In Int J Clin Exp Pathol, 2012
However, the tumor demonstrated moderately (2+) or strongly (3+) positive staining for TFEB, Cathepsin K, Ksp-cadherin, and vimentin but negative for TFE3, CD10, HMB45, melan A, CKpan, and CK7.
Hnf-1β transcription factor is an early hif-1α-independent marker of epithelial hypoxia and controls renal repair.
Chauveau et al., Toulouse, France. In Plos One, 2012
These changes are associated to tubular epithelial differentiation as assessed by KSP-cadherin and megalin-cubilin endocytic complex expression analysis.
Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN.
Linehan et al., Bethesda, United States. In J Natl Cancer Inst, 2012
METHODS: Mice with conditional alleles of FLCN and/or peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A), a transcriptional coactivator that regulates mitochondrial biogenesis, were crossbred with mice harboring either muscle creatine kinase (CKM) -Cre or myogenin (MYOG) -Cre transgenes to knock out FLCN and/or PPARGC1A in muscle, or cadherin 16 (CDH16)- Cre transgenes to knock out FLCN and/or PPARGC1A in kidney.
CDH16/Ksp-cadherin is expressed in the developing thyroid gland and is strongly down-regulated in thyroid carcinomas.
Nitsch et al., Napoli, Italy. In Endocrinology, 2012
In thyroid carcinomas, as determined by quantitative RT-PCR, CDH16 expression decreases in papillary, follicular, and anaplastic thyroid carcinomas, and the decrease is more pronounced than that of CDH1.
An essential role for Pax8 in the transcriptional regulation of cadherin-16 in thyroid cells.
Zannini et al., Napoli, Italy. In Mol Endocrinol, 2012
study concludes that Cadherin-16 is a novel downstream target of the transcription factor Pax8, likely since the early steps of thyroid development, and that its expression is associated with the fully differentiated state of the thyroid cell
Immunohistochemical diagnosis of renal neoplasms.
Shen et al., Houston, United States. In Arch Pathol Lab Med, 2011
CONCLUSIONS: The following markers may have diagnostic utility in various diagnostic contexts: cytokeratins, vimentin, α-methylacyl coenzyme A racemase, carbonic anhydrase IX, PAX2, PAX8, RCC marker, CD10, E-cadherin, kidney-specific cadherin, parvalbumin, claudin-7, claudin-8, S100A1, CD82, CD117, TFE3, thrombomodulin, uroplakin III, p63, and S100P.
Squamous differentiation in a sarcomatoid chromophobe renal cell carcinoma: an unusual case report with review of the literature.
Amin et al., Mumbai, India. In Arch Pathol Lab Med, 2008
Kidney-specific cadherin was positive in the chromophobe renal cell carcinoma areas and negative in the sarcomatoid and squamous areas.
alpha B-crystallin is a cytoplasmic interaction partner of the kidney-specific cadherin-16.
Klein et al., Tübingen, Germany. In J Mol Biol, 2008
The interaction of Ksp-cadherin with alpha B-crystallin is important for the connection of Ksp-cadherin to the cytoskeleton and thus for maintaining tissue integrity in the kidney.
Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications.
Amin et al., Atlanta, United States. In Am J Surg Pathol, 2007
Ksp-cad is a useful tumor type associated marker for distinguishing chromophobe renal cell carcinoma and renal oncocytoma from the wide range of nonintercalated cell-related adult renal epithelial neoplasms.
Expression of Ksp-cadherin during kidney development and in renal cell carcinoma.
Klein et al., Tübingen, Germany. In Br J Cancer, 2005
Ksp-cadherin expression downregulated inrenal cell carcinoma; this cell adhesion molecule may have role in tumour suppression
Following the expression of a kidney-specific gene from early development to adulthood.
Igarashi, Dallas, United States. In Nephron Exp Nephrol, 2002
Ksp-cadherin (Cadherin 16) is a unique, tissue-specific member of the cadherin family of cell adhesion proteins that is expressed exclusively in tubular epithelial cells in the adult kidney and developing genitourinary (GU) tract.
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