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Kringle containing transmembrane protein 2

Krm2, Kremen2
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: DKK1, Kremen, LRP6, fibrillin-1, AP-1
Papers on Krm2
Role of wingless tail signaling pathway in osteoporosis: an update of current knowledge.
Toulis et al., ThessalonĂ­ki, Greece. In Curr Opin Endocrinol Diabetes Obes, 2011
RECENT FINDINGS: New insights into the mechanisms regulating Wnt/β-catenin canonical pathway, including the role of Kremen-2 receptor, lamin A/C protein, periostin, and pleiotropin in bone physiology, the crosstalk between the RUNX-2 transcription-factor cascade and the Wnt pathway, and the concept that individual Wnt ligands may have a unique and distinct mission in bone milieu, are presented.
A microarray study of altered gene expression in colorectal cancer cells after treatment with immunomodulatory drugs: differences in action in vivo and in vitro.
Galustian et al., London, United Kingdom. In Mol Biol Rep, 2010
Notably, the expressions of linked genes within the Notch/Wnt signalling pathway, including kremen2 and dtx4, highlighted a possible novel mechanistic pathway for these drugs.
Dickkopf-1 promotes hyperglycemia-induced accumulation of mesangial matrix and renal dysfunction.
Wang et al., Taiwan. In J Am Soc Nephrol, 2010
In vitro, HG increased expression of DKK1, receptor Kremen-2, TGF-beta1, and fibronectin in mesangial cells.
A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V).
Bodine et al., United States. In J Cell Biochem, 2010
However, co-transfection of LRP5 with the chaperone protein MesD (which itself does not bind Dkk1) or Kremen-2 (a known Dkk1 receptor), or both, resulted in a marked enhancement of specific binding that was sufficient for evaluation of Dkk1 antagonists.
Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2.
Schinke et al., Hamburg, Germany. In Plos One, 2009
effects of Krm2 on bone remodeling
Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma.
Hou et al., Shanghai, China. In Mol Cancer, 2009
The mRNA expression levels of DKK-1 binding receptor LRP5/6 and Krm1/2 in SCs from patients with MM were significantly higher than those in myeloma cells and in SCs from healthy donors.
Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling.
Niehrs et al., Heidelberg, Germany. In Development, 2007
Here we show that Krm2 functions independently from Dkks during neural crest (NC) induction in Xenopus.
Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling.
Niehrs et al., Heidelberg, Germany. In Gene, 2003
Here we show that Kremen2 (Krm2) regulates Dkk2 activity during Wnt signaling.
Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning.
Niehrs et al., Heidelberg, Germany. In Development, 2002
In addition to LRP6, Dkk1 interacts with another recently identified receptor class, the transmembrane proteins Kremen1 (Krm1) and Kremen2 (Krm2) to synergistically inhibit LRP6.
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.
Niehrs et al., Heidelberg, Germany. In Nature, 2002
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.
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