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Kringle containing transmembrane protein 1

Kremen, Krm1, Kremen1
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DKK1, LRP6, Krm2, CAN, M VP
Papers on Kremen
Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner.
Pierani et al., Paris, France. In Cell Death Differ, Feb 2016
Here we describe a novel apoptotic signaling pathway involving the transmembrane receptor Kremen1 and its ligand, the Wnt-antagonist Dickkopf1.
Key role of Dkk3 protein in inhibition of cancer cell proliferation: An in silico identification.
Khalili et al., Tehrān, Iran. In J Theor Biol, Feb 2016
Herein, we aimed at launching an in silico study to determine Dkk3 structure and its interactions with Kremen and LRP as Wnt signaling receptors as well as EGF receptor.
Keeping Wnt signalosome in check by vesicular traffic.
Gao et al., Newark, United States. In J Cell Physiol, Jun 2015
Updates are provided for the regulatory mechanisms related to the three critical cell surface complexes, Wnt-Fzd-LRP6, Dkk1-Kremen-LRP6, and R-spondin-LGR5-RNF43, which potently influence Wnt signaling.
Kremen1 restricts Dkk activity during posterior lateral line development in zebrafish.
Nechiporuk et al., Portland, United States. In Development, 2014
We have identified a zebrafish strain, krm1(nl10), which carries a mutation in the kremen1 gene, a non-obligate co-receptor for the Dkk family of proteins.
[Anti-Dickkopf1 (Dkk1) antibody as a bone anabolic agent for the treatment of osteoporosis].
Inoue et al., Japan. In Clin Calcium, 2014
Dkk1 forms a ternary complex with LRP5/6 and Kremen, resulting in suppression of Wnt signaling and decreased bone formation.
Osteoblast-specific Krm2 overexpression and Lrp5 deficiency have different effects on fracture healing in mice.
Ignatius et al., Ulm, Germany. In Plos One, 2013
Two transmembrane proteins that are involved in decreasing the activity of this pathway by binding to extracellular antagonists, such as Dickkopf 1 (Dkk1), are the low-density lipoprotein receptor related protein 5 (Lrp5) and Kremen 2 (Krm2).
Smooth muscle cells differentiated from reprogrammed embryonic lung fibroblasts through DKK3 signaling are potent for tissue engineering of vascular grafts.
Xu et al., London, United Kingdom. In Circ Res, 2013
It was revealed that dickkopf 3 transcriptionally regulated SM22 by potentiation of Wnt signaling and interaction with Kremen1.
EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic development.
Luo et al., Beibei, China. In Dev Cell, 2013
EpCAM directly binds to Kremen1 and disrupts the Kremen1-Dickkopf2 (Dkk2) interaction, which prevents Kremen1-Dkk2-mediated removal of Lipoprotein-receptor-related protein 6 (Lrp6) from the cell surface.
Expression profiling in spondyloarthropathy synovial biopsies highlights changes in expression of inflammatory genes in conjunction with tissue remodelling genes.
Brown et al., Australia. In Bmc Musculoskelet Disord, 2012
The inflammatory mediator, MMP3, was strongly upregulated (5-fold) in AS/SpA samples and the Wnt pathway inhibitors DKK3 (2.7-fold) and Kremen1 (1.5-fold) were downregulated.
MicroRNA-431 regulates axon regeneration in mature sensory neurons by targeting the Wnt antagonist Kremen1.
Murashov et al., Philadelphia, United States. In Front Mol Neurosci, 2012
In the present study, we show that nerve injury-induced miR-431 stimulates regenerative axon growth by silencing Kremen1, an antagonist of Wnt/beta-catenin signaling.
Role of wingless tail signaling pathway in osteoporosis: an update of current knowledge.
Toulis et al., Thessaloníki, Greece. In Curr Opin Endocrinol Diabetes Obes, 2011
RECENT FINDINGS: New insights into the mechanisms regulating Wnt/β-catenin canonical pathway, including the role of Kremen-2 receptor, lamin A/C protein, periostin, and pleiotropin in bone physiology, the crosstalk between the RUNX-2 transcription-factor cascade and the Wnt pathway, and the concept that individual Wnt ligands may have a unique and distinct mission in bone milieu, are presented.
Animal models in bariatric surgery--a review of the surgical techniques and postsurgical physiology.
Kini et al., New York City, United States. In Obes Surg, 2010
Since the first publication of an article by Kremen, Linner, and Nelson, many experiments have been performed using animal models.
Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population.
Ozaki et al., Nagoya, Japan. In Schizophr Res, 2010
This study demonstrated that a representative tSNP of KREMEN1 might modulate the risk of schizophrenia in the Japanese population.
Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma.
Hou et al., Shanghai, China. In Mol Cancer, 2009
The mRNA expression levels of DKK-1 binding receptor LRP5/6 and Krm1/2 in SCs from patients with MM were significantly higher than those in myeloma cells and in SCs from healthy donors.
Roles of Dickkopf-1 and its receptor Kremen1 during embryonic implantation in mice.
Duan et al., Beijing, China. In Fertil Steril, 2008
Dkk1 and Kremen1 play roles in blastocyst activation and uterine receptivity during the window of implantation.
Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism.
Wu et al., Wuhan, China. In J Biol Chem, 2008
Kremen may not be essential for Dkk1-mediated Wnt antagonism and Kremen may only play a role when cells express a high level of LRP5/6
Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density.
Niehrs et al., Heidelberg, Germany. In Mol Cell Biol, 2008
This study provides the first genetic evidence for a functional interaction of Kremen proteins with Dkk1 as negative regulators of Wnt/beta-catenin signaling.
The functions and possible significance of Kremen as the gatekeeper of Wnt signalling in development and pathology.
Matsumoto et al., Kanazawa, Japan. In J Cell Mol Med, 2008
Kremen (Krm) was originally discovered as a novel transmembrane protein containing the kringle domain.
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.
Niehrs et al., Heidelberg, Germany. In Nature, 2002
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling
Environmental policy. Counting the cost of deforestation.
Bloomfield et al., Washington, D.C., United States. In Science, 2000
In this issue, a cost-benefit analysis by Kremen et al. demonstrates the benefits of forest conservation on a local and global scale.
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