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Human immunodeficiency virus type I enhancer binding protein 3

KRC, HIVEP3, Schnurri-3, ZAS3
This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: XRCC1, CAN, CD45, HAD, V1a
Papers on KRC
Tissue-specificity of heparan sulfate biosynthetic machinery in cancer.
Grigorieva et al., Novosibirsk, Russia. In Cell Adh Migr, Dec 2015
To reveal cancer-related changes in transcriptional pattern of HS biosynthetic system, the expression of HS metabolism-involved genes (EXT1/2, NDST1/2, GLCE, 3OST1/HS3ST1, SULF1/2, HPSE) in human normal (fibroblasts, PNT2) and cancer (MCF7, LNCaP, PC3, DU145, H157, H647, A549, U2020, U87, HT116, KRC/Y) cell lines and breast, prostate, colon tumors was studied.
Effects of KRC-108 on the Aurora A activity and growth of colorectal cancer cells.
Han et al., Chinju, South Korea. In Biochem Biophys Res Commun, Jul 2015
KRC-108 is a novel multi-kinase inhibitor which has anti-tumor activity in vivo.
TCGA data and patient-derived orthotopic xenografts highlight pancreatic cancer-associated angiogenesis.
Korc et al., Indianapolis, United States. In Oncotarget, May 2015
Using data from The Cancer Genome Atlas we demonstrate that a subset of PDACs exhibits a strong pro-angiogenic signature that includes 37 genes, such as HDAC9, that are overexpressed in PDAC arising in KRC mice, which express mutated Kras and lack RB.
Association mapping of the PARK10 region for Parkinson's disease susceptibility genes.
Zabetian et al., Seattle, United States. In Parkinsonism Relat Disord, 2014
BACKGROUND: Previous studies indicate that as many as six genes within the PARK10 region (RNF11, UQCRH, HIVEP3, EIF2B3, USP24, ELAVL4) might modify susceptibility or age at onset in Parkinson's disease (PD).
Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-β to promote proliferation.
Korc et al., In J Clin Invest, 2014
TGF-β1 treatment enhanced proliferation of PCCs isolated from KrasG12D-driven mPDAC that lacked RB (KRC cells).
Combined overexpression of HIVEP3 and SOX9 predicts unfavorable biochemical recurrence-free survival in patients with prostate cancer.
Zhong et al., Guangzhou, China. In Onco Targets Ther, 2013
BACKGROUND: To clarify the involvement of HIVEP3 and SOX9 coexpression in prostate cancer (PCa).
Comparison of two methods for analysis of gene-environment interactions in longitudinal family data: the Framingham heart study.
Rao et al., Saint Louis, United States. In Front Genet, 2013
Therefore, we compared two methods for analysis of longitudinal family data: a methodologically sound but computationally demanding method using the Kronecker model (KRC) and a computationally more forgiving method using the hierarchical linear model (HLM).
Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.
Jones et al., New York City, United States. In J Clin Invest, 2013
Mice deficient in Schnurri-3 (SHN3; also known as HIVEP3) display increased bone formation, but harnessing this observation for therapeutic benefit requires an improved understanding of how SHN3 functions in osteoblasts.
KRC-408, a novel c-Met inhibitor, suppresses cell proliferation and angiogenesis of gastric cancer.
Hong et al., Inch'ŏn, South Korea. In Cancer Lett, 2013
Thus, we developed KRC-408 as a novel c-Met inhibitor and investigated its anti-cancer effects on human gastric cancer.
KRC-327, a selective novel inhibitor of c-Met receptor tyrosine kinase with anticancer activity.
Hong et al., Inch'ŏn, South Korea. In Cancer Lett, 2013
We synthesized a novel triazolopyridazine derivative KRC-327 which selectively targets the c-Met.
Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus.
Jarjour et al., Columbus, United States. In Mol Immunol, 2013
The ZAS3 locus encodes a signaling and transcriptional molecule involved in regulating inflammatory responses.
Control of bone resorption in mice by Schnurri-3.
Glimcher et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Shn3 expression in mesenchymal cells directly controls osteoblastic bone formation and indirectly regulates osteoclastic bone resorption.
LRRC3B gene is frequently epigenetically inactivated in several epithelial malignancies and inhibits cell growth and replication.
Zabarovsky et al., Stockholm, Sweden. In Biochimie, 2012
In addition we showed that LRRC3B exhibit strong cell growth inhibiting activity (more than 95%) in colony formation experiments in vitro in KRC/Y renal cell carcinoma line.
Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients' survival.
Xu et al., Jinan, China. In Br J Cancer, 2012
In vitro, we examined the expression of CIP2A and c-Myc and tested the migration and invasion capability of A498 and KRC/Y cells with scratch migration assay and Matrigel invasion assay after down-regulating CIP2A expression using siRNA.
High-throughput single-nucleotide polymorphism discovery and the search for candidate genes for long-term SIVmac nonprogression in Chinese rhesus macaques (Macaca mulatta).
Smith et al., Davis, United States. In J Med Primatol, 2011
The region of greatest LD difference was located on the proximal end of chromosome one, which also contained the genes ELAVL4, MAST2 and HIVEP3.
ZAS3 promotes TNFα-induced apoptosis by blocking NFϰB-activated expression of the anti-apoptotic genes TRAF1 and TRAF2.
Hong et al., South Korea. In Bmb Rep, 2011
The inhibitory effect of ZAS3 on NF-kappa B activity is mediated by neither direct association with N-kappa B nor disrupting nuclear localization of NFvarkappaB.
ZAS3 accentuates transforming growth factor β signaling in epithelial cells.
Barnard et al., Columbus, United States. In Cell Signal, 2011
An interaction between ZAS3 and Smad proteins enhances transforming growth factor beta signaling.
ZAS3 represses NFκB-dependent transcription by direct competition for DNA binding.
Wu et al., Columbus, United States. In Bmb Rep, 2010
DNA competition by ZAS3 is sufficient to repress transcription activated by NF-kappaB and that ZAS3 is an endogenous kappaB-motif competitor with ininsic repression activity.
The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis.
Wu et al., Columbus, United States. In Plos One, 2010
ZAS3 was a crucial molecule in osteoclast differentiation.
ZAS: C2H2 zinc finger proteins involved in growth and development.
Wu, Columbus, United States. In Gene Expr, 2001
Three paralogous mammalian genes, ZAS1, ZAS2, and ZAS3, and a related Drosophila gene, Schnurri, have been cloned and characterized.
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