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Kallikrein-related peptidase 6

KLK6, kallikrein 6, KLK7, hK6, kallikrein 7, hK7, protease M, SCCE
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Kallikrein, KLK5, CAN, Trypsin, HAD
Papers on KLK6
Intracellular FRET-based screen for redesigning the specificity of secreted proteases.
Daugherty et al., In Acs Chem Biol, Feb 2016
To evolve a human protease that selectively cleaves within the central hydrophobic core (KLVF↓F↓AED) of the amyloid beta (Aβ) peptide, PrECISE was applied to human kallikrein 7, a protease with Aβ cleavage activity but broad selectivity, with a strong preference for tyrosine (Y) at P1.
Inhibitors of kallikrein-related peptidases 7 and 5 by grafting serpin reactive center loop sequences onto sunflower trypsin inhibitor-1 (SFTI-1).
Beck-Sickinger et al., Leipzig, Germany. In Chembiochem, Dec 2015
To develop peptidic protease inhibitors kallikrein-related peptidases 7 (KLK7) and 5 (KLK5) were chosen.
Novel RNA variants in colorectal cancers.
Skotheim et al., Oslo, Norway. In Oncotarget, Dec 2015
These include a recurrent read-through fusion transcript between KLK8 and KLK7, and a splice variant of S100A2.
Genetic targeting of protease activated receptor 2 reduces inflammatory astrogliosis and improves recovery of function after spinal cord injury.
Scarisbrick et al., Rochester, United States. In Neurobiol Dis, Nov 2015
The potential mechanistic link between PAR2, STAT3 and astrogliosis was further investigated in primary astrocytes to reveal that the SCI-related serine protease, neurosin (kallikrein 6) promotes IL-6 secretion in a PAR2 and STAT3-dependent manner.
The role of human kallikrein 6, clusterin and adiponectin as potential blood biomarkers of dementia.
Diamandis et al., Zagreb, Croatia. In Clin Biochem, Nov 2015
It was suggested that serum human kallikrein 6 (KLK6), clusterin (CLU) and adiponectin (ADPN) in combination with inflammation markers, neuroimaging and neuropsychological testing could assist in discriminating dementia patients from control individuals.
Identification of vitamin D3 target genes in human breast cancer tissue.
Callen et al., Adelaide, Australia. In J Steroid Biochem Mol Biol, Nov 2015
Ketoconazole potentiated 1,25D-mediated induction of CLMN, SERPINB1, and KLK6 mRNA through inhibition of 24-hydroxylase (CYP24A1) activity.
Development of Monoclonal Antibodies and Characterization of an ELISA Platform Against Kallikrein-Related Peptidase 6 as a Tumor Biomarker.
Huang et al., Xinhui, China. In Monoclon Antib Immunodiagn Immunother, Oct 2015
Kallikrein-related peptidase 6 (KLK6) is a serine protease, and one of fifteen kallikrein members located on chromosome 19.
KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome.
Hovnanian et al., Paris, France. In Plos Genet, Sep 2015
Spink5⁻/⁻ mice recapitulate the NS phenotype, display enhanced epidermal Klk5 and Klk7 protease activities and die within a few hours after birth because of a severe skin barrier defect.
Prognostic significance of multiple kallikreins in high-grade astrocytoma.
Scarisbrick et al., Rochester, United States. In Bmc Cancer, 2014
METHODS: In this study we determined KLK1, KLK6, KLK7, KLK8, KLK9 and KLK10 protein expression in two independent tissue microarrays containing 60 grade IV and 8 grade III astrocytoma samples.
Structure of plasma and tissue kallikreins.
Emsley et al., Nottingham, United Kingdom. In Thromb Haemost, 2013
A zymogen crystal structure determined for KLK6 reveals a closed S1 pocket and a novel mechanism of zymogen activation.
Netherton syndrome: skin inflammation and allergy by loss of protease inhibition.
Hovnanian, Paris, France. In Cell Tissue Res, 2013
In vitro and in vivo studies in murine models and in NS patients have cast light on the pathogenesis of the disease and shown that LEKTI deficiency results in unopposed kallikrein-related peptidase 5 (KLK5) and KLK7 activities and to the overactivity of a new epidermal protease, elastase 2 (ELA2).
TH2 cytokines increase kallikrein 7 expression and function in patients with atopic dermatitis.
Iwatsuki et al., In J Allergy Clin Immunol, 2012
The enhancement of protease activity through increased KLK7 expression by the TH2 cytokines IL-4 and IL-13 might be an important factor for mechanical and chemical epidermal barrier dysfunction in patients with atopic dermatitis.
Lymph node tissue kallikrein-related peptidase 6 mRNA: a progression marker for colorectal cancer.
Hammarström et al., Umeå, Sweden. In Br J Cancer, 2012
in colorectal cancer patients, lymph node KLK6 positivity indicated presence of aggressive tumour cells associated with poor prognosis and high risk of tumour recurrence
Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer.
Lee et al., Taejŏn, South Korea. In Tumour Biol, 2012
KLK6 is significantly upregulated and secreted in gastric cancer tissues and sera, suggesting that KLK6 might be used as a potential biomarker and therapeutic target for gastric cancer.
Kallikrein 6 is a novel molecular trigger of reactive astrogliosis.
Vandell et al., Rochester, United States. In Biol Chem, 2012
KLK6 is positioned to serve as a molecular trigger of select physiological processes involved in the development of astrogliosis
Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients.
Magdolen et al., München, Germany. In Biol Chem, 2012
KLK6 expressed by stromal cells may considerably contribute to the aggressiveness of ovarian cancer
The physiology and pathobiology of human kallikrein-related peptidase 6 (KLK6).
Diamandis et al., Toronto, Canada. In Clin Chem Lab Med, 2012
The human kallikrein-related peptidase 6 (KLK6) gene belongs to the 15-member kallikrein (KLK) gene family mapping to chromosome 19q13.3-13.4.
Soluble E-cadherin: more than a symptom of disease.
Day et al., Ann Arbor, United States. In Front Biosci, 2011
The proteases implicated in this cleavage event include members of the disintegrin family (ADAM10 and 15), bacterial proteases (gingipains and BFT), cathepsins (B, L, S), matrix metalloproteases (MMP-2, 3, 7, 9, and 14), Kallikrein-7 (KLK7), and plasmin.
Kallikrein-related peptidases: proteolysis and signaling in cancer, the new frontier.
Hollenberg et al., Calgary, Canada. In Biol Chem, 2010
We have further documented the presence of active KLK6 and 10 (by activity-based ELISA or proteomics) and the presence of proteinase inhibitors, such as alpha(1)-antitrypsin, in cancer-derived fluids.
Human kallikrein 6 (hK6): a new potential serum biomarker for diagnosis and prognosis of ovarian carcinoma.
Katsaros et al., Toronto, Canada. In J Clin Oncol, 2003
PATIENTS AND METHODS: We measured, by immunoassay, human kallikrein 6 (hK6) concentration in serum of 97 apparently healthy women, 141 women with benign abdominal diseases, and 146 women with histologically proven primary ovarian carcinoma.
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