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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Kallikrein-related peptidase 4

KLK4, kallikrein 4, PstS, Arm I, prostase
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Alternate splice variants for this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Kallikrein, Matrix Metalloproteinase 20, CAN, HAD, hK2
Papers using KLK4 antibodies
Gene Dosage–limiting Role of Aire in Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity
Goodnow Christopher C. et al., In The Journal of Experimental Medicine, 2001
... ), and KLK4 H-2k:mHEL transgenic mice ( ...
Papers on KLK4
Adaptive Evolution Favoring KLK4 Downregulation in East Asians.
Seixas et al., Porto, Portugal. In Mol Biol Evol, Jan 2016
encodes 15 serine proteases, including neighboring genes (KLK3, KLK2, KLK4, and KLK5) with key roles in the cascades of semen liquefaction, tooth enamel maturation, and skin desquamation.
Maturation stage enamel malformations in Amtn and Klk4 null mice.
Simmer et al., San Antonio, United States. In Matrix Biol, Dec 2015
UNASSIGNED: Amelotin (AMTN) and kallikrein-4 (KLK4) are secreted proteins specialized for enamel biomineralization.
Inactivation of C4orf26 in toothless placental mammals.
Gatesy et al., Riverside, United States. In Mol Phylogenet Evol, Dec 2015
UNASSIGNED: Previous studies have reported inactivated copies of six enamel-related genes (AMBN, AMEL, AMTN, ENAM, KLK4, MMP20) and one dentin-related gene (DSPP) in one or more toothless vertebrates and/or vertebrates with enamelless teeth, thereby providing evidence that these genes are enamel or tooth-specific with respect to their critical functions that are maintained by natural selection.
Micro-RNA analysis of renal biopsies in human lupus nephritis demonstrates up-regulated miR-422a driving reduction of kallikrein-related peptidase 4.
Bertsias et al., Irákleion, Greece. In Nephrol Dial Transplant, Dec 2015
In transfection studies, miR-422a was found to directly target kallikrein-related peptidase 4 (KLK4) mRNA.
Sublingual immunization with the phosphate binding-protein (PstS) reduces oral colonization by Streptococcus mutans.
Ferreira et al., São Paulo, Brazil. In Mol Oral Microbiol, Nov 2015
Streptococcus mutans is the etiological agent of dental caries, and previous studies have demonstrated that deletion of the gene encoding PstS, the substrate-binding component of the phosphate uptake system (Pst), reduced the adherence of the bacteria to abiotic surfaces.
Development of a Reagentless Biosensor for Inorganic Phosphate, Applicable over a Wide Concentration Range.
Webb et al., London, United Kingdom. In Biochemistry, Sep 2015
A fluorescent reagentless biosensor for inorganic phosphate (Pi), based on the E. coli PstS phosphate binding protein, was redesigned to allow measurements of higher Pi concentrations and at low, substoichiometric concentrations of biosensor.
A phase II open-label clinical study of comparing nab-paclitaxel with pemetrexed as second-line chemotherapy for patients with stage IIIB/IV non-small-cell lung cancer.
Jiao et al., Beijing, China. In Med Oncol, Aug 2015
Arm I received pemetrexed 500 mg/m(2) intravenously (i.v.) on day 1 of 3-week cycle.
Impact of Treatment Time on Chemoradiotherapy in Locally Advanced Cervical Carcinoma.
Chander et al., New Delhi, India. In Asian Pac J Cancer Prev, 2014
Arm I (n=25) treatment consisted of irradiation of the whole pelvis to a dose of 50 Gy in 27 fractions, and weekly cisplatin 40 mg/m2.
Testing health information technology tools to facilitate health insurance support: a protocol for an effectiveness-implementation hybrid randomized trial.
Gold et al., Portland, United States. In Implement Sci, 2014
Eligible CHC clinic sites will be randomly assigned to one of two groups in the trial's implementation component: tools + basic training (Arm I) and tools + enhanced training + facilitation (Arm II).
Missense Mutation in Fam83H Gene in Iranian Patients with Amelogenesis Imperfecta.
Heidari et al., Tehrān, Iran. In Iran J Public Health, 2014
The aim of this study was to screen mutations in the four most important candidate genes, ENAM, KLK4, MMP20 and FAM83H responsible for amelogenesis imperfect.
Kallikrein-related peptidase-4 (KLK4): role in enamel formation and revelations from ablated mice.
Simmer et al., Boston, United States. In Front Physiol, 2013
KLK4 is expressed during the transition from secretory to the maturation stage and its expression continues throughout maturation.
Emerging clinical importance of the cancer biomarkers kallikrein-related peptidases (KLK) in female and male reproductive organ malignancies.
Dorn et al., München, Germany. In Radiol Oncol, 2012
However, in breast cancer, KLK4 is elevated which is also true for ovarian and prostate cancer.
Amelogenesis imperfecta: an introduction.
Malik et al., In Br Dent J, 2012
Amelogenesis imperfecta (AI) is an inherited disorder that is associated with mutations in five genes (AMEL; ENAM; MMP20; KLK4 and FAM83H) with a wide range of clinical presentations (phenotypes).
Human kallikrein 4 signal peptide induces cytotoxic T cell responses in healthy donors and prostate cancer patients.
Radford et al., South Brisbane, Australia. In Cancer Immunol Immunother, 2012
signal peptide induces cytotoxic T cell responses in healthy donors and prostate cancer patients
Effect of kallikrein 4 loss on enamel mineralization: comparison with mice lacking matrix metalloproteinase 20.
Simmer et al., Montréal, Canada. In J Biol Chem, 2011
Effect of kallikrein 4 loss on enamel mineralization: comparison with mice lacking matrix metalloproteinase 20.
Defining a new candidate gene for amelogenesis imperfecta: from molecular genetics to biochemistry.
Cifuentes et al., Santiago, Chile. In Biochem Genet, 2011
These disorders are considered clinically and genetically heterogeneous in etiology, involving a variety of genes, such as AMELX, ENAM, DLX3, FAM83H, MMP-20, KLK4, and WDR72.
Why does enamel in Klk4-null mice break above the dentino-enamel junction?
Hu et al., Ann Arbor, United States. In Cells Tissues Organs, 2010
The breakage of enamel near the dentino-enamel junction in Klk4-null mice is not due to a failure of odontoblasts to express Klk4, but it relates to a progressive hypomineralization of enamel with depth.
A variant of the KLK4 gene is expressed as a cis sense-antisense chimeric transcript in prostate cancer cells.
Nelson et al., Australia. In Rna, 2010
Complex gene expression at the KLK4 locus that might be a hallmark of cis sense-antisense chimeric transcription in prostate cancer cells.
Polyclonal antibodies against kallikrein-related peptidase 4 (KLK4): immunohistochemical assessment of KLK4 expression in healthy tissues and prostate cancer.
Magdolen et al., München, Germany. In Biol Chem, 2010
KLK4 is upregulated in early-stage but not late-stage prostate cancer.
Thoracic radiation therapy added to chemotherapy for small-cell lung cancer: an update of Cancer and Leukemia Group B Study 8083.
Green et al., Columbia, United States. In J Clin Oncol, 1998
PATIENTS AND METHODS: Three hundred ninety-nine patients with limited-stage small-cell lung cancer were randomized to receive thoracic radiation therapy that started on day 1 (arm I) or day 64 of chemotherapy treatment (arm II), or chemotherapy alone with cyclophosphamide, vincristine, and etoposide (later, doxorubicin).
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