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Kallikrein-related peptidase 10

KLK10, NES1, kallikrein 10, normal epithelial cell-specific 1
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Kallikrein, KLK6, CAN, HAD, KLK5
Papers on KLK10
Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development.
Macklin et al., Shanghai, China. In J Neurosci, Jan 2016
We identified three functional nuclear export sequences (NES) localized in the basic helix-loop-helix domain and one specific acetylation site at Lys 150 (human Olig1) in NES1.
Upregulated KLK10 inhibits esophageal cancer proliferation and enhances cisplatin sensitivity in vitro.
Li et al., Dalian, China. In Oncol Rep, Nov 2015
The kallikrein-related peptidase 10 (KLK10) gene has tumor-suppressive function in various types of human cancer.
A calreticulin-dependent nuclear export signal is involved in the regulation of liver receptor homologue-1 protein folding.
Hu et al., Taipei, Taiwan. In Biochem J, Nov 2015
Mutation of leucine residues in NES1 or NES2 abolished nuclear export, indicating that both NES1 and NES2 motifs are essential for full nuclear export activity.
Expression and bioregulation of the kallikrein-related peptidases family in the human neutrophil.
Figueroa et al., Valdivia, Chile. In Innate Immun, Aug 2015
RT-PCR showed that blood neutrophils expressed only KLK1, KLK4, KLK10, KLK13, KLK14 and KLK15 mRNAs, whereas the non-differentiated HL-60 cells expressed most of them, with exception of KLK3 and KLK7.
Human kallikrein 10 expression in surgically removed human pituitary corticotroph adenomas: an immunohistochemical study.
Yousef et al., Medellín, Colombia. In Appl Immunohistochem Mol Morphol, Jul 2015
Human kallikrein 10 (hk10), a secreted serine protease, was reported to function as a tumor suppressor.
Human kallikrein 10 in surgically removed human pituitary adenomas.
Yousef et al., Toronto, Canada. In Hormones (athens), Apr 2015
OBJECTIVE: Human kallikrein-like peptidase 10 (KLK10), a serine protease, plays an important role in the regulation of cell proliferation and tumor growth.
Evaluation of human tissue kallikrein-related peptidases 6 and 10 expression in early gastroesophageal adenocarcinoma.
Yousef et al., Toronto, Canada. In Hum Pathol, Apr 2015
In this study, we investigated kallikrein-related peptidase 6 (KLK6) and KLK10 expression in early gastroesophageal junction adenocarcinoma and Barrett esophagus (BE) with and without dysplasia.
Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2:ERG fusion-positive versus fusion-negative tumors.
Stanford et al., Seattle, United States. In Clin Epigenetics, 2014
A number of top-ranked differentially methylated CpGs in genes (FDR Q-values ≤1.53E-29) were identified: C3orf14, CACNA1D, GREM1, KLK10, NT5C, PDE4D, RAB40C, SEPT9, and TRIB2, several of which had a corresponding alteration in mRNA expression.
NES1/KLK10 gene represses proliferation, enhances apoptosis and down-regulates glucose metabolism of PC3 prostate cancer cells.
Li et al., Shanghai, China. In Sci Rep, 2014
The normal epithelial cell-specific-1 (NES1) gene, also named as KLK10, is recognised as a novel putative tumour suppressor in breast cancer, but few studies have focused on the function of KLK10 in human prostate cancer.
Prognostic significance of multiple kallikreins in high-grade astrocytoma.
Scarisbrick et al., Rochester, United States. In Bmc Cancer, 2014
METHODS: In this study we determined KLK1, KLK6, KLK7, KLK8, KLK9 and KLK10 protein expression in two independent tissue microarrays containing 60 grade IV and 8 grade III astrocytoma samples.
Evaluation and prognostic significance of human tissue kallikrein-related peptidase 10 (KLK10) in colorectal cancer.
Yousef et al., Athens, Greece. In Tumour Biol, 2012
Data indicate a statistically significant positive association between kallikrein-related peptidase 10 (KLK10) and tumor stage and liver metastases.
Expression analysis and clinical evaluation of kallikrein-related peptidase 10 (KLK10) in colorectal cancer.
Xynopoulos et al., Athens, Greece. In Tumour Biol, 2011
KLK10 gene expression may be used as a marker of unfavorable prognosis for colorectal cancer
The association with age, human tissue kallikreins 6 and 10 and hemostatic markers for survival outcome from epithelial ovarian cancer.
Ovarian Cancer Research Consortium of SE Asia et al., Singapore, Singapore. In Arch Gynecol Obstet, 2011
upregulated in late stage epithelial ovarian cancer
Kallikreins 5, 6 and 10 differentially alter pathophysiology and overall survival in an ovarian cancer xenograft model.
Vanderhyden et al., Ottawa, Canada. In Plos One, 2010
Loss of KLK10 is associated with ovarian cancer.
Kallikrein-related peptidase 10 (KLK10) expression and single nucleotide polymorphisms in ovarian cancer survival.
Spurdle et al., Australia. In Int J Gynecol Cancer, 2010
Single nucleotide polymorphisms in KLK10 is not associated with ovarian cancer.
Human kallikrein 10, a predictive marker for breast cancer.
Band et al., Evanston, United States. In Biol Chem, 2006
REVIEW of KLK10 gene expression in neoplasm cells
Tissue kallikreins: new players in normal and abnormal cell growth?
Diamandis et al., Toronto, Canada. In Thromb Haemost, 2003
KLK10 may act as a tumor suppressor.
Human tissue kallikreins and testicular cancer.
Diamandis et al., Toronto, Canada. In Apmis, 2003
In testicular germ cell tumors, some tissue kallikrein genes, including KLK5, KLK10, KLK13 and KLK14, were found to be significantly down-regulated.
Molecular biology and genetics of breast cancer development: a clinical perspective.
Wazer et al., Houston, United States. In Semin Radiat Oncol, 2002
It is now recognized that mutations in some tumor suppressor genes, such as p53, BRCA1, BRCA2, PTEN, or ATM, or epigenetic functional inactivation of other tumor suppressor genes, such as SYK and NES1, appear to play important early roles in the formation of some breast cancers.
The new human kallikrein gene family: implications in carcinogenesis.
Obiezu et al., Toronto, Canada. In Trends Endocrinol Metab, 2000
During the past two to three years, new putative members of the human kallikrein gene family have been identified, including the PRSSL1 gene [encoding normal epithelial cell-specific 1 gene (NES1)], the gene encoding zyme/protease M/neurosin, the gene encoding prostase/KLK-L1, and the genes encoding neuropsin, stratum corneum chymotryptic enzyme and trypsin-like serine protease.
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