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Kruppel-like factor 8

KLF8, Kruppel-like factor 8, ZNF741, BKLF3
This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: V1a, E-cadherin, CAN, PCNA, vimentin
Papers on KLF8
Krüppel-like transcription factor 8 (Klf8) is expressed and active in the neurons of the mouse brain.
Gajović et al., Zagreb, Croatia. In Gene, Nov 2015
Krüppel-like transcription factor 8 (KLF8) is a transcription factor suggested to be involved in various cellular events, including malignant cell transformation, still its expression in the adult rodent brain remained unknown.
KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2.
Wang et al., Guangzhou, China. In Oncotarget, Oct 2015
However, the molecular mechanism by which KLF8 affects FHL2-mediated tumor proliferation, EMT and metastasis remains unknown.
MiR-135a inhibits migration and invasion and regulates EMT-related marker genes by targeting KLF8 in lung cancer cells.
Fang et al., Xi'an, China. In Biochem Biophys Res Commun, Oct 2015
Further studies revealed that the transcription factor KLF8 was a target gene of miR-135a in NSCLC cells, as miR-135a bound directly to the 3'-untranslated region (3'-UTR) of KLF8, thus reducing both the expression of KLF8 at the mRNA and protein levels.
KLF8 is required for bladder cancer cell proliferation and migration.
Lu et al., Harbin, China. In Biotechnol Appl Biochem, Sep 2015
Krüppel-like factor 8 (KLF8) belongs to the Sp/KLF family of transcription factors.
Suppression of KLF8 induces cell differentiation and sensitizes colorectal cancer to 5-fluorouracil.
Wang et al., Guangzhou, China. In Oncol Rep, Sep 2015
KLF8 is a member of the KLF transcription factor family that plays an important role in oncogenesis.
Modulation of p53 and met expression by Krüppel-like factor 8 regulates zebrafish cerebellar development.
Hwang et al., Taipei, Taiwan. In Dev Neurobiol, Sep 2015
Krüppel-like factor 8 (Klf8) is a zinc-finger transcription factor implicated in cell proliferation, and cancer cell survival and invasion; however, little is known about its role in normal embryonic development.
Identification of epidermal growth factor receptor and its inhibitory microRNA141 as novel targets of Krüppel-like factor 8 in breast cancer.
Zhao et al., Orlando, United States. In Oncotarget, Sep 2015
Krüppel-like factor 8 (KLF8) is a dual transcriptional factor critical for breast cancer progression.
Small hairpin RNA-mediated Krüppel-like factor 8 gene knockdown inhibits invasion of nasopharyngeal carcinoma.
Li et al., Wuhan, China. In Oncol Lett, Jun 2015
UNASSIGNED: The present study aimed to characterize the expression of Krüppel-like factor 8 (KLF8) in nasopahryngeal carcinoma (NPC) cell lines and determine its effect on tumor development and invasion following KLF8 gene knockdown by small hairpin RNA (shRNA).
Krüppel-like factors in hepatocellular carcinoma.
Ma et al., Shanghai, China. In Tumour Biol, Feb 2015
To date, five members (KLF4, KLF6, KLF8, KLF9, and KLF17) in the KLF family have been reported to function in the pathogenesis of HCC in multiple ways, which hold the potential of deepening and widening our understanding in the initiation and progression of HCC.
In vitro activity of the mTOR inhibitor everolimus, in a large panel of breast cancer cell lines and analysis for predictors of response.
Slamon et al., Los Angeles, United States. In Breast Cancer Res Treat, Feb 2015
Transcript expression microarrays identified GSK3A, PIK3R3, KLF8, and MAPK10 among the genes overexpressed in sensitive luminal lines, while PGP, RPL38, GPT, and GFAP were among the genes overexpressed in resistant luminal cell lines.
Krüppel-like factor 8 involved in hypoxia promotes the invasion and metastasis of gastric cancer via epithelial to mesenchymal transition.
Zhang et al., Xi'an, China. In Oncol Rep, 2014
Krüppel-like factor 8 (KLF8) as a transcriptional repressor has been suggested as a promoter of tumor metastasis in breast cancer and an inducer of the epithelial‑mesenchymal transition (EMT).
Krüppel -like factor 8 is a stress-responsive transcription factor that regulates expression of HuR.
Lee et al., Columbus, United States. In Cell Physiol Biochem, 2013
KLF8, but not Sp1, was shown to bind this site and increase HuR mRNA levels.
DNA methylation signatures for prediction of biochemical recurrence after radical prostatectomy of clinically localized prostate cancer.
Sørensen et al., Århus, Denmark. In J Clin Oncol, 2013
RESULTS: Hypermethylation of AOX1, C1orf114, GAS6, HAPLN3, KLF8, and MOB3B was highly cancer specific (area under the curve, 0.89 to 0.98).
Krüppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation.
Schichor et al., München, Germany. In Plos One, 2011
Kruppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation.
Identification of poly (ADP-ribose) polymerase-1 (PARP-1) as a novel Kruppel-like factor 8-interacting and -regulating protein.
Zhao et al., Orlando, United States. In J Biol Chem, 2011
PARP-1 as a novel KLF8-binding and -regulating protein and provided new insights into the mechanisms underlying the regulation of KLF8 nuclear localization, stability, and functions.
KLF8 promotes human breast cancer cell invasion and metastasis by transcriptional activation of MMP9.
Zhao et al., Orlando, United States. In Oncogene, 2011
Immunohistochemical staining strongly correlated the co-expression of KLF8 and MMP9 with the patient tumor invasion, metastasis and poor survival
Up-regulation of Krüppel-like factor 8 promotes tumor invasion and indicates poor prognosis for hepatocellular carcinoma.
Fan et al., Shanghai, China. In Gastroenterology, 2010
KLF8 promotes hepatocellular carcinoma cell proliferation and invasion, inhibits apoptosis, and induces the epithelial-to-mesenchymal transition
Small interference RNA targeting Krüppel-like factor 8 inhibits the renal carcinoma 786-0 cells growth in vitro and in vivo.
Zhu et al., China. In J Cancer Res Clin Oncol, 2010
KLF8 is possibly involved in regulating cell growth, invasion, apoptosis, and proliferation of renal carcinoma cancer; blocking this protein may be a therapeutic strategy for this cancer.
Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review).
Katoh et al., Japan. In Int J Mol Med, 2008
SNAI1 (Snail), SNAI2 (Slug), SNAI3, ZEB1, ZEB2 (SIP1), KLF8, TWIST1, and TWIST2 are EMT regulators repressing CDH1 gene encoding E-cadherin.
New concepts regarding focal adhesion kinase promotion of cell migration and proliferation.
Gladson et al., Birmingham, United States. In J Cell Biochem, 2006
FAK also plays an important role in regulating cell cycle progression through transcriptional control of the cyclin D1 promoter by the Ets B and Kruppel-like factor 8 (KLF8) transcription factors.
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