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Kruppel-like factor 13

KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: SP1, BTEB, KLF11, V1a, CAN
Papers on KLF13
Mouse Endometrium Temporal and Spatial Expression mRNA and MicroRNA Associated With Embryo Implantation.
Wang et al., Chongqing, China. In Reprod Sci, Nov 2015
Hub miRNAs (mmu-miR-96 and mmu-miR-200b) were identified to target B-cell lymphoma 2 (Bcl-2), Kruppel-like factor 13 (Klf13), and Progesterone receptor (PGR), which are associated with the preparation of the receptive condition or the maintenance of early pregnancy.
Krüppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis.
Simmen et al., Little Rock, United States. In Biol Reprod, Jun 2015
Here we evaluated whether KLF13 loss of expression in endometrial cells may equally contribute to lesion formation.
Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC).
Relton et al., Newcastle upon Tyne, United Kingdom. In Hum Mol Genet, May 2015
In cord blood, methylation at 15 CpG sites in seven gene regions (AHRR, MYO1G, GFI1, CYP1A1, CNTNAP2, KLF13 and ATP9A) was associated with maternal smoking, and a dose-dependent response was observed in relation to smoking duration and intensity.
Copy number variants in attention-deficit hyperactive disorder: identification of the 15q13 deletion and its functional role.
Scassellati et al., Tel Aviv-Yafo, Israel. In Psychiatr Genet, Apr 2015
As expected, genes in the deleted region (KLF13, MTMR10) were downregulated in the two patients with deletions.
Immune system-related differentially expressed genes, transcription factors and microRNAs in post-menopausal females with osteopenia.
Yin et al., Shanghai, China. In Scand J Immunol, Mar 2015
PAX5 could regulate 15 DEGs including ZFP36L2 and KLF13.
Vitamin C induces a pluripotent state in mouse embryonic stem cells by modulating microRNA expression.
Zhang et al., China. In Febs J, Feb 2015
The miRNAs in this region contain identical seed sequences, which target a class of genes, including Kdm6b, Klf13, and Sox6, and are mainly related to cell differentiation and development.
Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells.
Lock et al., Sydney, Australia. In Blood, Feb 2015
Microarray analysis showed that KLF13 and MYB gene expression changes were significantly greater in dexamethasone-sensitive than -resistant PDXs.
KLF13 promotes porcine adipocyte differentiation through PPARγ activation.
Jiang et al., Wuhan, China. In Cell Biosci, 2014
RESULTS: In the present study, we showed that KLF13 acts as a key regulator regulating porcine adipocyte differentiation.
Partial tetrasomy of the proximal long arm of chromosome 15 in two patients: the significance of the gene dosage in terms of phenotype.
Melegh et al., Pécs, Hungary. In Mol Cytogenet, 2014
On the other hand increased dosage of the KLF13 gene seems to have no direct causal relationship with heart morphology.
KLF13 cooperates with c-Maf to regulate IL-4 expression in CD4+ T cells.
Clayberger et al., Chicago, United States. In J Immunol, 2014
In this study, we document a key role for KLF13 in the expression of IL-4 in CD4(+) T cells.
miR-125a-5p regulates differential activation of macrophages and inflammation.
Liu et al., Birmingham, United States. In J Biol Chem, 2014
We found that miR-125a-5p targets KLF13, a transcriptional factor that has an important role in T lymphocyte activation and inflammation.
Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.
Krensky et al., Bethesda, United States. In Blood, 2012
Fbw7 gamma - mediated ubiquitination of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.
KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells.
Krensky et al., Bethesda, United States. In J Exp Med, 2011
KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells.
CCR5, RANTES and SDF-1 polymorphisms and mother-to-child HIV-1 transmission.
Farquhar et al., Seattle, United States. In Int J Immunogenet, 2010
No associations were found between maternal genetic polymorphisms in RANTES (-403G/A) and mother-to-child HIV-1 transmission; plasma, cervical and breastmilk viral loads; or breastmilk chemokine concentrations.
Functional differentiation of uterine stromal cells involves cross-regulation between bone morphogenetic protein 2 and Kruppel-like factor (KLF) family members KLF9 and KLF13.
Simmen et al., Little Rock, United States. In Endocrinology, 2010
Data support cross-regulation among BMP2, KLF9, and KLF13 to maintain progesterone sensitivity in stromal cells undergoing differentiation and suggest that loss of this network compromises establishment of uterine receptivity and implantation success.
Overexpression of KLF13 and FGFR3 in oral cancer cells.
Gollin et al., Pittsburgh, United States. In Cytogenet Genome Res, 2010
KLF13 contributes to malignancy in oral cancer cells and may be a useful biomarker fo early detection and da possible target for therapy.
Mechanisms of disease: regulation of RANTES (CCL5) in renal disease.
Ahn et al., Stanford, United States. In Nat Clin Pract Nephrol, 2007
By contrast, expression of RANTES in T lymphocytes 3-5 days after activation requires the development of a molecular complex (enhancesome) including KLF13 (Krueppel-like factor 13), rel proteins p50 and p65, and scaffolding proteins.
The KLF family of transcriptional regulators in cardiomyocyte proliferation and differentiation.
Horb et al., Montréal, Canada. In Cell Cycle, 2007
Starting with the dissection of a new regulatory sequence required for cardiac specific expression, we identified the cognate DNA binding protein as KLF13, a tissue-restricted member of the newly identified KLF family of zinc-finger proteins.
Transcriptional regulation of RANTES expression in T lymphocytes.
Krensky et al., Stanford, United States. In Immunol Rev, 2000
RANTES factor of late activated T lymphocytes (RFLAT)-1 is a member of the Krüppel-like family of transcription factors.
RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.
Krensky et al., Stanford, United States. In Immunity, 1999
Using expression cloning, we identified the first "late" T lymphocyte associated transcription factor and named it "RANTES Factor of Late Activated T Lymphocytes-1" (RFLAT-1).
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