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Polo-like kinase 1 substrate 1

KIZ, Kizuna, GM114, polo-like kinase 1 substrate
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Top mentioned proteins: Plk1, LIM, PCM, CAN, V1a
Papers on KIZ
Whole-exome sequencing identifies KIZ as a ciliary gene associated with autosomal-recessive rod-cone dystrophy.
Audo et al., Paris, France. In Am J Hum Genet, 2014
Herein, we applied whole-exome sequencing to a consanguineous family with one subject affected with RCD and identified a homozygous nonsense mutation, c.226C>T (p.Arg76(∗)), in KIZ, which encodes centrosomal protein kizuna.
Kizuna is a novel mitotic substrate for CDC25B phosphatase.
Baldin et al., Montpellier, France. In Cell Cycle, 2013
We found, using the same CDC25B mutant, that stabilization and failure to degrade CDC25B during mitosis lead to the appearance of multipolar spindle cells resulting from a fragmentation of pericentriolar material (PCM) and abolish mitotic Plk1-dependent phosphorylation of Kizuna (Kiz), which is essential for the function of Kiz in maintaining spindle pole integrity.
World's first telepathology experiments employing WINDS ultra-high-speed internet satellite, nicknamed "KIZUNA".
Hopson et al., Japan. In J Pathol Inform, 2012
In this study we experimented with telepathology in collaboration with JAXA using Kizuna.
Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo.
Strebhardt et al., Frankfurt am Main, Germany. In Am J Pathol, 2011
Notably, centrosomal fragmentation induced by Poloxin is partially attributable to dysfunctional Kizuna, a key substrate of Plk1 at centrosomes.
Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation.
Yamamoto et al., Tokyo, Japan. In Embo J, 2009
The PCM is thought to be created by two cognate large coiled-coil proteins, pericentrin/kendrin and CG-NAP/AKAP450, and its stabilization by Kizuna is essential for bipolar spindle formation.
Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam.
Capel et al., Durham, United States. In Dev Biol, 2008
Results describe the expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam.
Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization.
Montoya et al., Madrid, Spain. In Proc Natl Acad Sci U S A, 2007
Polo-like kinase (Plk1) is crucial for cell cycle progression through mitosis.
Sealed with a Kiz: How Plk1 ensures spindle pole integrity.
Baxter et al., Leicester, United Kingdom. In Dev Cell, 2006
A new study by Yamamoto and coworkers has identified a centrosomal protein, Kizuna (Kiz), as a mitotic substrate of Plk1 (Oshimori et al., 2006).
The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity.
Yamamoto et al., Tokyo, Japan. In Nat Cell Biol, 2006
Here, we identify a novel centrosomal substrate of Plk1, Kizuna (Kiz), depletion of which causes fragmentation and dissociation of the pericentriolar material from centrioles at prometaphase, resulting in multipolar spindles.
[Ex post opinion on work disability in a payment decision case].
Berent et al., In Arch Med Sadowej Kryminol, 2005
This paper describes a case of ex post opinion in the judgement of work disability for purposes of benefit qualification, in which numerous, frequently contradictory disability certifications by KIZ, WKIZ, ZUS physician-certifiers and court medical opinions were issued.
[Examination of an after-hour emergency telephone consultation by Kizuna visiting nurse station].
Takahashi et al., College Station, United States. In Gan To Kagaku Ryoho, 2004
From inception, Kizuna visiting nurse station has been giving a 24-hour service because it is highly regarded as being most dependable in providing medical care service to a patient and family members since we started doing this service.
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase.
Caroni et al., Basel, Switzerland. In Nature, 1998
LIM-kinase 1, also known as KIZ, is a protein kinase with two amino-terminal LIM motifs that induces stabilization of F-actin structures in transfected cells.
Kiz-1, a protein with LIM zinc finger and kinase domains, is expressed mainly in neurons.
Dringen et al., Melbourne, Australia. In Cell Growth Differ, 1994
This complementary DNA, designated Kiz-1, encodes a protein containing two prominent domains; the NH2-terminal region contains a cysteine/histidine-rich moiety previously identified as a zinc-finger domain in proteins of the LIM family, while the COOH-terminus contains a kinase domain.
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