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Potassium inwardly-rectifying channel, subfamily J, member 10

Kir4.1, Sesame, KCNJ10
This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: KIR, AQP4, CAN, Aquaporin 1, Kir5.1
Papers using Kir4.1 antibodies
Murine middle ear inflammation and ion homeostasis gene expression.
Juhn Steven K., In PLoS ONE, 2010
... KCNJ10, (C-terminal)Rabbit IgG Purified Polyclonal AntibodyAbcam Inc ...
Papers on Kir4.1
Inwardly rectifying potassium channel 4.1 expression in post-traumatic syringomyelia.
Hemley et al., Sydney, Australia. In Neuroscience, Feb 2016
The ion channel Kir4.1 plays an important role in the uptake of K+ ions from the extracellular space and release of K+ ions into the microvasculature, generating an osmotic gradient that drives water movement.
Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections.
Verkman et al., San Francisco, United States. In Biophys J, Jan 2016
Two-color superresolution imaging demonstrated colocalization of Kir4.1 with AQP4 clusters in perivascular areas but not in parenchyma.
Evaluation of a Multimedia Intervention for Children and Families Facing Multiple Military Deployments.
MacDermid Wadsworth et al., West Lafayette, United States. In J Prim Prev, Jan 2016
Created by Sesame Workshop and using popular Sesame Street characters, TLC-II MD was designed to support and equip families with young children with skills to address challenges associated with multiple deployments.
Roles and Regulation of Renal K Channels.
Welling, Baltimore, United States. In Annu Rev Physiol, Jan 2016
Recently, a confluence of discoveries in areas from human genetics to physiology, cell biology, and biophysics has cast light on the special function of five different potassium channels in the distal nephron, encoded by the genes KCNJ1, KCNJ10, KCNJ16, KCNMA1, and KCNN3.
Insulin and IGF-1 activate Kir4.1/5.1 channels in cortical collecting duct principal cells to control basolateral membrane voltage.
Pochynyuk et al., Houston, United States. In Am J Physiol Renal Physiol, Jan 2016
UNASSIGNED: Potassium Kir4.1/5.1 channels are abundantly expressed at the basolateral membrane of principal cells in the cortical collecting duct (CCD) where they are thought to modulate transport rates by controlling trans-epithelial voltage.
Müller glia activation by VEGF-antagonizing drugs: An in vitro study on rat primary retinal cultures.
Malchiodi-Albedi et al., Roma, Italy. In Exp Eye Res, Jan 2016
Upregulation of Kir4.1 and AQP4 suggests that Müller glia activation following anti-VEGF drugs may not depict a detrimental gliotic reaction.
Uniform heating of materials into the warm dense matter regime with laser-driven quasimonoenergetic ion beams.
Fernández et al., United States. In Phys Rev E Stat Nonlin Soft Matter Phys, Dec 2015
According to calculations and SESAME equation-of-state tables, laser-driven aluminum ion beams achievable at Trident, with a finite energy spread of ΔE/E∼20%, are expected to heat the targets more uniformly than a beam of 140-MeV aluminum ions with zero energy spread.
Biomarkers in multiple sclerosis.
Hafler et al., New Haven, United States. In Clin Immunol, Nov 2015
We go on to discuss other potential biomarkers from MS serum and cerebrospinal fluid including Markers of neurodegeneration including neurofilament and GFAP, the monocyte macrophage marker CD163, the glial activation marker YKL-40, the B cell chemoattractant CXCL13, miRNA and mRNA, myelin reactive t cells, Kir4.1 antibodies, osteopontin, and microbiome associated lipopeptides.
New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling.
Rouach et al., Paris, France. In J Neurosci, Nov 2015
Dysfunction of a major astrocyte K(+) channel, Kir4.1, appears as an early pathological event underlying neuronal phenotypes in several neurodevelopmental and neurodegenerative diseases.
[EAST/SeSAME syndrome and functional expression of inward rectifier potassium channel Kir4.1 in the inner ear].
Zhao et al., In Lin Chuang Er Bi Yan Hou Ke Za Zhi, Jul 2015
In this review, we mainly focus on the expression and function of Kir4.1 channels in the inner ear and mutation-induced EAST/SeSAME syndromes to provide insight for understanding the pathogenesis of deafness induced by KCNJ10 deficiency.
Critical care ultrasound in cardiac arrest. Technological requirements for performing the SESAME-protocol - a holistic approach.
Malbrain et al., Antwerp, Belgium. In Anaesthesiol Intensive Ther, 2014
This paper will focus on the use of the SESAME-protocol in cardiac arrest.
Investigation of the KIR4.1 potassium channel as a putative antigen in patients with multiple sclerosis: a comparative study.
Lennon et al., Rochester, United States. In Lancet Neurol, 2014
BACKGROUND: Antibodies have been implicated in the pathogenicity of multiple sclerosis by findings of immunoglobulins in patients' CSF and often IgG and complement in lesions, and by a 2012 report that nearly half of patients' serum samples contain IgG specific for a glial potassium-channel, KIR4.1.
Loss of perivascular Kir4.1 potassium channels in the sclerotic hippocampus of patients with mesial temporal lobe epilepsy.
de Lanerolle et al., Oslo, Norway. In J Neuropathol Exp Neurol, 2012
This study demonistrated that Loss of perivascular Kir4.1 potassium channels in the sclerotic hippocampus of patients with mesial temporal lobe epilepsy.
Inwardly rectifying potassium channel Kir4.1 is localized at the calyx endings of vestibular afferents.
Okabe et al., Tokyo, Japan. In Neuroscience, 2012
This study demonistrated that Kir4.1 is expressed not only in glial cells but also in neurons of the mouse vestibular system.
Potassium channel KIR4.1 as an immune target in multiple sclerosis.
Hemmer et al., München, Germany. In N Engl J Med, 2012
Using a proteomic approach focusing on membrane proteins, we identified the ATP-sensitive inward rectifying potassium channel KIR4.1 as the target of the IgG antibodies.
Screening of SLC26A4, FOXI1, KCNJ10, and GJB2 in bilateral deafness patients with inner ear malformation.
Jiang et al., Guangzhou, China. In Otolaryngol Head Neck Surg, 2012
No KCNJ10 mutations were present in bilateral deafness patients with inner ear malformation.
Kir4.1 channels mediate a depolarization of hippocampal astrocytes under hyperammonemic conditions in situ.
Rose et al., Düsseldorf, Germany. In Glia, 2012
This study demonistrated that Kir4.1 channels mediate a depolarization of hippocampal astrocytes under hyperammonemic conditions.
Relationship between glial potassium regulation and axon excitability: a role for glial Kir4.1 channels.
Butt et al., Portsmouth, United Kingdom. In Glia, 2012
The results demonstrated the importance of glial Kir in K(+) spatial buffering and sustaining axonal activity in the optic nerve.
Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations.
Kleta et al., London, United Kingdom. In N Engl J Med, 2009
Mutations in KCNJ10 cause a specific disorder. Our findings indicate that KCNJ10 plays a major role in renal salt handling and possibly also in blood-pressure maintenance and its regulation.
MATERIALS SCIENCE: Armenia Wants Second Mideast Synchrotron.
Koenig, In Science, 2000
Last spring, SESAME (Synchrotron Radiation for Experimental Science and Applications in the Middle East), an 11-nation consortium formed to install and operate a first-generation synchrotron now mothballed in Germany, selected Jordan as the site of the 0.8 giga-electron-volt BESSY-I synchrotron, disappointing Armenian officials who had hoped to snare the prize.
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