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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2

KIR2DL2, p58.2
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: KIR, KIR2DL1, p58, CAN, HAD
Papers on KIR2DL2
Phase II Study of Haploidentical Natural Killer Cell Infusion for Treatment of Relapsed or Persistent Myeloid Malignancies Following Allogeneic Hematopoietic Cell Transplantation.
Hsu et al., New York City, United States. In Biol Blood Marrow Transplant, Feb 2016
We found a slight trend towards greater expression of KIR2DL2/2DL3/2DS2 (5% versus 28%, P = 0.03) at 14 days in patients who survived longer than 6 months from NK cell infusion (N = 4) when compared to those who died within 6 months of NK cell therapy (N=3).
Characterization of KIR intermediate promoters reveals four promoter types associated with distinct expression patterns of KIR subtypes.
Anderson et al., Frederick, United States. In Genes Immun, Jan 2016
The current study identifies ProI elements in all of the KIR genes, revealing four classes of ProI that correspond with four distinct expression phenotypes of KIR subgroups: KIR2DL2/S2/L3 that are expressed early in reconstituting NK after transplant; KIR2DL4 that is expressed by CD56-bright NK in a non-variegated manner; KIR3DL3 that is not expressed by circulating NK cells; and the remaining KIR that are expressed by subsets of CD56-dim NK.
Killer cell immunoglobulin-like receptor gene association with cryptorchidism.
Kurpisz et al., Wrocław, Poland. In Reprod Biol, Dec 2015
KIR2DL2 (killer immunoglobulin-like receptor two-domain long 2) and KIR2DS2 (killer immunoglobulin-like receptor two-domain short 2) genes were less frequent in patients than in control individuals (corrected p values: 0.0110 and 0.0383, respectively).
Significant association of the KIR2DL3/HLA-C1 genotype with susceptibility to Crohn's disease.
Castro-Santos et al., Oviedo, Spain. In Hum Immunol, Dec 2015
Our results confirm the relevance of the KIR2DL2/KIR2DL3 genes and their interaction with HLA-C to CD.
Investigation of activating and inhibitory killer cell immunoglobulin-like receptors and their putative ligands in type 1 diabetes (T1D).
ElGhazali et al., Riyadh, Saudi Arabia. In Hum Immunol, Dec 2015
KIR2DL2/2DS2-C1C1 and KIR2DL3-C1C1 were significantly associated with T1D, and KIR2DS1-C2C2 and KIR2DL1-C2C2 were significantly less frequent in T1D patients.
NK cells: tuned by peptide?
Khakoo et al., Columbus, United States. In Immunol Rev, Sep 2015
HLA-E binding non-inhibitory peptides augment inhibition at CD94:NKG2A, while HLA-C binding non-inhibitory peptides antagonize inhibition at KIR2DL2/3, implying that KIRs are specialized to respond positively to changes in peptide repertoire.
Association of Killer Cell Immunoglobulin- Like Receptor Genes in Iranian Patients with Rheumatoid Arthritis.
Mansouri et al., Yazd, Iran. In Plos One, 2014
RESULTS: KIR2DL2, 2DL5a, 2DL5b and activating KIR: KIR2DS5 and 3DS1 were all protective against RA.
NK Cell Subgroups, Phenotype, and Functions After Autologous Stem Cell Transplantation.
Ullrich et al., Oslo, Norway. In Front Immunol, 2014
Moreover, these NK cells strongly upregulated KIR2DL2/3/S2 and KIR3DL1, whereas KIR2DL1/S1 remained constant, indicating that this cell population arose from more immature NK cells instead of from activated mature ones.
Ancient Genetic Signatures of Orang Asli Revealed by Killer Immunoglobulin-Like Receptor Gene Polymorphisms.
Zafarina et al., Malaysia. In Plos One, 2014
Orang Kanaq, the smallest and the most endangered of all OA subgroups, has lost some degree of genetic variation, as shown by their relatively high frequency of the AB2 genotype (0.73) and a total absence of KIR2DL2 and KIR2DS2 genes.
Are killer cell immunoglobulin-like receptor genes important for the prediction of kidney graft rejection?
Kuśnierczyk, Wrocław, Poland. In Arch Immunol Ther Exp (warsz), 2013
Their results are not concordant: some authors found no effect of KIR genotype, whereas others detected protective effect of KIR2DL2/KIR2DS2 or KIR-KIR ligand mismatch.
Altered natural killer cells' response to herpes virus infection in multiple sclerosis involves KIR2DL2 expression.
Rotola et al., Ferrara, Italy. In J Neuroimmunol, 2012
The results are the first direct proof of the implication of KIR2DL2 receptor in the control of natural killer cell activation towards herpes virus infection in multiple sclerosis.
Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3.
Parham et al., Stanford, United States. In J Immunol, 2012
Amino acid variation at positions 68, 70, and 182 modulates the binding avidity of KIR2DL for histocompatibility antigen HLA-C compared to KIR2DL3.
The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms.
Gandhi et al., Brisbane, Australia. In Blood Coagul Fibrinolysis, 2012
In a comparison of healthy controls and a tightly defined cohort of adult ITP patients, the KIR2DS2/KIR2DL2 genotype was found to be associated with ITP independently of FCGR3a-158 polymorphisms.
KIR2DL2 enhances protective and detrimental HLA class I-mediated immunity in chronic viral infection.
Asquith et al., London, United Kingdom. In Plos Pathog, 2011
in two unrelated viral infections, hepatitis C virus and human T lymphotropic virus type 1, possession of the KIR2DL2 gene enhanced both protective and detrimental HLA class I-restricted anti-viral immunity.
Identification of four novel KIR2DL2 alleles and two novel KIR2DL3 alleles in an East African population.
Luo et al., Winnipeg, Canada. In Hum Immunol, 2010
We report four novel KIR2DL2 alleles and two novel KIR2DL3 alleles identified from an East African population using sequence-based typing.
Structure and function of natural-killer-cell receptors.
Sun, Rockville, United States. In Immunol Res, 2002
Through structural studies of members of these distinct receptor families, in particular, the structure and recognition between KIR2DL2 and HLA-Cw3, that between NKG2D and ULBP3, and that between CD16 and IgG Fc, considerable understandings have been achieved about their function and their ligand recognition.
A structural perspective on MHC class I recognition by killer cell immunoglobulin-like receptors.
Sun et al., Rockville, United States. In Mol Immunol, 2002
This has resulted in the crystal structures of several members of the KIR family and more recently the determinations of the three dimensional structures of KIR2DL2 and KIR2DL1 complexed with their respective ligands, HLA-Cw3 and HLA-Cw4.
Structure of killer cell immunoglobulin-like receptors and their recognition of the class I MHC molecules.
Sun et al., Rockville, United States. In Immunol Rev, 2001
The recent determination of the crystal structure of KIR2DL2 in complex with HLA-Cw3 has revealed the molecular mechanisms underpinning this interaction, which ultimately modulates the cytolytic activity of natural killer cells.
Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex.
Wiley et al., Cambridge, United States. In Nat Immunol, 2001
Many residues conserved in HLA-C and in KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and in a previously reported KIR2DL2-HLA-Cw3 complex.
Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand.
Sun et al., Rockville, United States. In Nature, 2000
Here we report the crystal structure of the human immunoglobulin-like NK cell receptor KIR2DL2 in complex with its class I ligand HLA-Cw3 and peptide.
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